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Predominantly vegetarian diet in patients with incipient and early clinical diabetic nephropathy: effects on albumin excretion rate and nutritional status.

Abstract

Several studies have suggested that dietary protein quality may be an important determinant in the natural history of renal disease. We have therefore studied the effects of a predominantly vegetarian diet in eight patients with Type 1 diabetes mellitus and an albumin excretion rate (AER) in excess of 30 micrograms min-1. The AER was measured after an 8-week run-in period on the patient's usual diet, and again after 8 weeks of a predominantly vegetarian diet in which the proportion of vegetable protein was supplemented in order to minimize the reduction in total dietary protein intake. The median fractional albumin clearance fell during the study from an initial value of 188 x 10(-+) (range 58-810 x 10(-4)) at the end of the run-in period to 87 x 10(-4) (23-829 x 10(-4)) at the end of the period on low animal protein diet (difference 79 x 10(-4) (95% Cl 9-149 x 10(-4)), p less than 0.05). The AER then returned to values similar to those obtained at the beginning of the study after a further 8 weeks in those patients returning to their usual diet. No significant changes in blood glucose control or in arterial pressure were observed. A predominantly vegetarian diet may therefore have important beneficial effects on diabetic nephropathy without the need for a heavily restricted total protein intake.

Authors+Show Affiliations

,

Renal Unit, Ysbyty Gwynedd, Bangor, UK.

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Source

MeSH

Albuminuria
Biomarkers
Blood Pressure
Diabetes Mellitus, Type 1
Diabetic Nephropathies
Diet, Diabetic
Diet, Vegetarian
Dietary Proteins
Energy Intake
Female
Fructosamine
Glomerular Filtration Rate
Hexosamines
Humans
Male
Meat
Middle Aged
Nutritional Status

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1838047

Citation

Jibani, M M., et al. "Predominantly Vegetarian Diet in Patients With Incipient and Early Clinical Diabetic Nephropathy: Effects On Albumin Excretion Rate and Nutritional Status." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 8, no. 10, 1991, pp. 949-53.
Jibani MM, Bloodworth LL, Foden E, et al. Predominantly vegetarian diet in patients with incipient and early clinical diabetic nephropathy: effects on albumin excretion rate and nutritional status. Diabet Med. 1991;8(10):949-53.
Jibani, M. M., Bloodworth, L. L., Foden, E., Griffiths, K. D., & Galpin, O. P. (1991). Predominantly vegetarian diet in patients with incipient and early clinical diabetic nephropathy: effects on albumin excretion rate and nutritional status. Diabetic Medicine : a Journal of the British Diabetic Association, 8(10), pp. 949-53.
Jibani MM, et al. Predominantly Vegetarian Diet in Patients With Incipient and Early Clinical Diabetic Nephropathy: Effects On Albumin Excretion Rate and Nutritional Status. Diabet Med. 1991;8(10):949-53. PubMed PMID: 1838047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predominantly vegetarian diet in patients with incipient and early clinical diabetic nephropathy: effects on albumin excretion rate and nutritional status. AU - Jibani,M M, AU - Bloodworth,L L, AU - Foden,E, AU - Griffiths,K D, AU - Galpin,O P, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez SP - 949 EP - 53 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 8 IS - 10 N2 - Several studies have suggested that dietary protein quality may be an important determinant in the natural history of renal disease. We have therefore studied the effects of a predominantly vegetarian diet in eight patients with Type 1 diabetes mellitus and an albumin excretion rate (AER) in excess of 30 micrograms min-1. The AER was measured after an 8-week run-in period on the patient's usual diet, and again after 8 weeks of a predominantly vegetarian diet in which the proportion of vegetable protein was supplemented in order to minimize the reduction in total dietary protein intake. The median fractional albumin clearance fell during the study from an initial value of 188 x 10(-+) (range 58-810 x 10(-4)) at the end of the run-in period to 87 x 10(-4) (23-829 x 10(-4)) at the end of the period on low animal protein diet (difference 79 x 10(-4) (95% Cl 9-149 x 10(-4)), p less than 0.05). The AER then returned to values similar to those obtained at the beginning of the study after a further 8 weeks in those patients returning to their usual diet. No significant changes in blood glucose control or in arterial pressure were observed. A predominantly vegetarian diet may therefore have important beneficial effects on diabetic nephropathy without the need for a heavily restricted total protein intake. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/1838047/full_citation L2 - https://medlineplus.gov/diabetickidneyproblems.html DB - PRIME DP - Unbound Medicine ER -