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Lipoprotein lipids and apolipoproteins (AI, AII, B, CII, CIII) in type 1 and type 2 diabetes mellitus in young Kuwaiti women.
Diabet Med 1991; 8(8):732-7DM

Abstract

Plasma lipid and apolipoprotein levels of Type 1 and Type 2 young Kuwaiti diabetic women on insulin therapy were investigated to elucidate the relationship between coronary artery disease risk factors and lipid levels. Forty Type 1 and 52 Type 2 diabetic women and 45 and 62 corresponding control subjects (matched for age and body mass index) were investigated. In comparison with control subjects, both groups of diabetic patients showed marked increases in total-cholesterol, LDL-cholesterol, triglycerides, very low density triglycerides, apolipoprotein B, glucose, fructosamine, and glycosylated haemoglobin HbA1c (all p less than 0.001). However, apolipoprotein CIII was significantly elevated in Type 2 diabetic patients (p less than 0.001) but not in Type 1 patients. Concentrations of apolipoproteins CII and AII in both diabetic groups were not significantly different from those in control subjects. Levels of HDL-, HDL2- and HDL3-cholesterol and plasma apolipoprotein AI were markedly decreased in both the diabetic groups compared with their control groups (all p less than 0.001 except HDL3-cholesterol in Type 1 diabetic vs control, p less than 0.05). In Type 2 diabetic patients, HbA1c correlated positively with triglycerides (r = 0.70, p less than 0.001), cholesterol (r = 0.60, p less than 0.001), apolipoprotein B (r = 0.77, p less than 0.001), and apolipoprotein CIII (r = 0.55, p less than 0.001) and negatively with apolipoprotein AI (r = -0.49, p less than 0.001). In Type 1 diabetic patients HbA1c correlated positively only with apolipoprotein CIII (r = 0.50, p less than 0.001).

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine, Kuwait University.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1838064

Citation

al-Muhtaseb, N, et al. "Lipoprotein Lipids and Apolipoproteins (AI, AII, B, CII, CIII) in Type 1 and Type 2 Diabetes Mellitus in Young Kuwaiti Women." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 8, no. 8, 1991, pp. 732-7.
al-Muhtaseb N, al-Yusef AR, Bajaj JS. Lipoprotein lipids and apolipoproteins (AI, AII, B, CII, CIII) in type 1 and type 2 diabetes mellitus in young Kuwaiti women. Diabet Med. 1991;8(8):732-7.
al-Muhtaseb, N., al-Yusef, A. R., & Bajaj, J. S. (1991). Lipoprotein lipids and apolipoproteins (AI, AII, B, CII, CIII) in type 1 and type 2 diabetes mellitus in young Kuwaiti women. Diabetic Medicine : a Journal of the British Diabetic Association, 8(8), pp. 732-7.
al-Muhtaseb N, al-Yusef AR, Bajaj JS. Lipoprotein Lipids and Apolipoproteins (AI, AII, B, CII, CIII) in Type 1 and Type 2 Diabetes Mellitus in Young Kuwaiti Women. Diabet Med. 1991;8(8):732-7. PubMed PMID: 1838064.
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TY - JOUR T1 - Lipoprotein lipids and apolipoproteins (AI, AII, B, CII, CIII) in type 1 and type 2 diabetes mellitus in young Kuwaiti women. AU - al-Muhtaseb,N, AU - al-Yusef,A R, AU - Bajaj,J S, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 732 EP - 7 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 8 IS - 8 N2 - Plasma lipid and apolipoprotein levels of Type 1 and Type 2 young Kuwaiti diabetic women on insulin therapy were investigated to elucidate the relationship between coronary artery disease risk factors and lipid levels. Forty Type 1 and 52 Type 2 diabetic women and 45 and 62 corresponding control subjects (matched for age and body mass index) were investigated. In comparison with control subjects, both groups of diabetic patients showed marked increases in total-cholesterol, LDL-cholesterol, triglycerides, very low density triglycerides, apolipoprotein B, glucose, fructosamine, and glycosylated haemoglobin HbA1c (all p less than 0.001). However, apolipoprotein CIII was significantly elevated in Type 2 diabetic patients (p less than 0.001) but not in Type 1 patients. Concentrations of apolipoproteins CII and AII in both diabetic groups were not significantly different from those in control subjects. Levels of HDL-, HDL2- and HDL3-cholesterol and plasma apolipoprotein AI were markedly decreased in both the diabetic groups compared with their control groups (all p less than 0.001 except HDL3-cholesterol in Type 1 diabetic vs control, p less than 0.05). In Type 2 diabetic patients, HbA1c correlated positively with triglycerides (r = 0.70, p less than 0.001), cholesterol (r = 0.60, p less than 0.001), apolipoprotein B (r = 0.77, p less than 0.001), and apolipoprotein CIII (r = 0.55, p less than 0.001) and negatively with apolipoprotein AI (r = -0.49, p less than 0.001). In Type 1 diabetic patients HbA1c correlated positively only with apolipoprotein CIII (r = 0.50, p less than 0.001). SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/1838064/Lipoprotein_lipids_and_apolipoproteins__AI_AII_B_CII_CIII__in_type_1_and_type_2_diabetes_mellitus_in_young_Kuwaiti_women_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -