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Diagnostic and prognostic significance of measuring antibodies to alpha-fodrin compared to anti-Ro-52, anti-Ro-60, and anti-La in primary Sjögren's syndrome.
J Rheumatol. 2008 May; 35(5):845-9.JR

Abstract

OBJECTIVE

To compare sensitivity and specificity of autoantibodies to alpha-fodrin with conventional anti-Ro and anti-La antibodies in patients with primary Sjögren's syndrome (pSS). Data on internal organ manifestations were correlated with presence of autoantibodies.

METHODS

We collected clinical and laboratory data from 321 patients with pSS (Copenhagen criteria), of which 205 fulfilled the new American-European 2002 consensus criteria. Sera were tested for autoantibodies against alpha-fodrin and recombinant Ro-52, Ro-60, and La proteins.

RESULTS

Antibodies to alpha-fodrin were not diagnostically superior to conventional anti-Ro/La testing. IgG anti-La had the highest specificity (97%). A highly significant association was found between presence of anti-La and internal organ manifestations (OR 6, 95% CI 2.99-12.03) or hematological abnormalities. The pattern of autoantibodies was relatively independent of disease duration, indicating that these antibodies appeared early in pSS, probably even years before the first symptoms were manifest.

CONCLUSION

We could not confirm that antibodies to alpha-fodrin had higher specificity or sensitivity than anti-Ro/La. Anti-La antibodies were strongly correlated to organ involvement and cytopenias, and thus could serve as a prognostic marker in pSS.

Authors+Show Affiliations

Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark. hlo@ssi.dkNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18381788

Citation

Locht, Henning, et al. "Diagnostic and Prognostic Significance of Measuring Antibodies to Alpha-fodrin Compared to anti-Ro-52, anti-Ro-60, and anti-La in Primary Sjögren's Syndrome." The Journal of Rheumatology, vol. 35, no. 5, 2008, pp. 845-9.
Locht H, Pelck R, Manthorpe R. Diagnostic and prognostic significance of measuring antibodies to alpha-fodrin compared to anti-Ro-52, anti-Ro-60, and anti-La in primary Sjögren's syndrome. J Rheumatol. 2008;35(5):845-9.
Locht, H., Pelck, R., & Manthorpe, R. (2008). Diagnostic and prognostic significance of measuring antibodies to alpha-fodrin compared to anti-Ro-52, anti-Ro-60, and anti-La in primary Sjögren's syndrome. The Journal of Rheumatology, 35(5), 845-9.
Locht H, Pelck R, Manthorpe R. Diagnostic and Prognostic Significance of Measuring Antibodies to Alpha-fodrin Compared to anti-Ro-52, anti-Ro-60, and anti-La in Primary Sjögren's Syndrome. J Rheumatol. 2008;35(5):845-9. PubMed PMID: 18381788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic and prognostic significance of measuring antibodies to alpha-fodrin compared to anti-Ro-52, anti-Ro-60, and anti-La in primary Sjögren's syndrome. AU - Locht,Henning, AU - Pelck,Randi, AU - Manthorpe,Rolf, Y1 - 2008/03/15/ PY - 2008/4/3/pubmed PY - 2008/8/22/medline PY - 2008/4/3/entrez SP - 845 EP - 9 JF - The Journal of rheumatology JO - J Rheumatol VL - 35 IS - 5 N2 - OBJECTIVE: To compare sensitivity and specificity of autoantibodies to alpha-fodrin with conventional anti-Ro and anti-La antibodies in patients with primary Sjögren's syndrome (pSS). Data on internal organ manifestations were correlated with presence of autoantibodies. METHODS: We collected clinical and laboratory data from 321 patients with pSS (Copenhagen criteria), of which 205 fulfilled the new American-European 2002 consensus criteria. Sera were tested for autoantibodies against alpha-fodrin and recombinant Ro-52, Ro-60, and La proteins. RESULTS: Antibodies to alpha-fodrin were not diagnostically superior to conventional anti-Ro/La testing. IgG anti-La had the highest specificity (97%). A highly significant association was found between presence of anti-La and internal organ manifestations (OR 6, 95% CI 2.99-12.03) or hematological abnormalities. The pattern of autoantibodies was relatively independent of disease duration, indicating that these antibodies appeared early in pSS, probably even years before the first symptoms were manifest. CONCLUSION: We could not confirm that antibodies to alpha-fodrin had higher specificity or sensitivity than anti-Ro/La. Anti-La antibodies were strongly correlated to organ involvement and cytopenias, and thus could serve as a prognostic marker in pSS. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/18381788/Diagnostic_and_prognostic_significance_of_measuring_antibodies_to_alpha_fodrin_compared_to_anti_Ro_52_anti_Ro_60_and_anti_La_in_primary_Sjögren's_syndrome_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=18381788 DB - PRIME DP - Unbound Medicine ER -