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Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses.
Diagn Mol Pathol. 2008 Sep; 17(3):145-50.DM

Abstract

Benign metastasizing leiomyomas are rare tumors, which are typically found in the lungs and, thus, might be confused with leiomyosarcomas. Further, it is not clear whether the term "benign metastasizing leiomyoma" is a misnomer and whether these lesions actually represent low-grade malignant tumors that have a low proliferation index. Micro-RNAs (miRNAs) are small noncoding RNAs, which repress translation. The altered expression of miRNAs has been strongly correlated with the malignant phenotype. In this study, the histologic features, Ki67 index, p53, bcl-2, and miRNA expression were studied in 15 leiomyosarcomas (11 primary lesions and 4 metastases), 8 leiomyomas, and 10 cases of benign metastasizing leiomyoma (9 pulmonary lesions and 1 primary uterine lesion). As expected, the Ki67 index for the benign metastasizing leiomyomas was equivalent to that for the leiomyomas and statistically less than that for the leiomyosarcomas. The mean index was 2.3% (range: 0.9% to 8.8%) for the leiomyomas and 3.4% (range: 0.7% to 8.1%) for the benign metastasizing leiomyomas compared with 28.6% (range: 14.4% to 62.0%) for the leiomyosarcomas (P<0.025). The miRNA, miR-221, which has been associated with a variety of cancers, was detected by in situ hybridization in 13/15 leiomyosarcomas, 0/8 leiomyomas, and 0/10 benign metastasizing leiomyomas. In conclusion, benign metastasizing leiomyomas are indeed most likely benign lesions, and up-regulation of miR-221 expression is an accurate way to differentiate leiomyosarcoma from benign metastasizing leiomyoma.

Authors+Show Affiliations

Department of Pathology, The Ohio State University Medical Center, Room 081 Heart and Lung Research Institute, 473 W 12th Avenue, Columbus, OH 43210, USA. gnuovomd@pol.netNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18382364

Citation

Nuovo, Gerard J., and Thomas D. Schmittgen. "Benign Metastasizing Leiomyoma of the Lung: Clinicopathologic, Immunohistochemical, and micro-RNA Analyses." Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B, vol. 17, no. 3, 2008, pp. 145-50.
Nuovo GJ, Schmittgen TD. Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses. Diagn Mol Pathol. 2008;17(3):145-50.
Nuovo, G. J., & Schmittgen, T. D. (2008). Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses. Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B, 17(3), 145-50. https://doi.org/10.1097/PDM.0b013e31815aca19
Nuovo GJ, Schmittgen TD. Benign Metastasizing Leiomyoma of the Lung: Clinicopathologic, Immunohistochemical, and micro-RNA Analyses. Diagn Mol Pathol. 2008;17(3):145-50. PubMed PMID: 18382364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses. AU - Nuovo,Gerard J, AU - Schmittgen,Thomas D, PY - 2008/4/3/pubmed PY - 2008/10/22/medline PY - 2008/4/3/entrez SP - 145 EP - 50 JF - Diagnostic molecular pathology : the American journal of surgical pathology, part B JO - Diagn. Mol. Pathol. VL - 17 IS - 3 N2 - Benign metastasizing leiomyomas are rare tumors, which are typically found in the lungs and, thus, might be confused with leiomyosarcomas. Further, it is not clear whether the term "benign metastasizing leiomyoma" is a misnomer and whether these lesions actually represent low-grade malignant tumors that have a low proliferation index. Micro-RNAs (miRNAs) are small noncoding RNAs, which repress translation. The altered expression of miRNAs has been strongly correlated with the malignant phenotype. In this study, the histologic features, Ki67 index, p53, bcl-2, and miRNA expression were studied in 15 leiomyosarcomas (11 primary lesions and 4 metastases), 8 leiomyomas, and 10 cases of benign metastasizing leiomyoma (9 pulmonary lesions and 1 primary uterine lesion). As expected, the Ki67 index for the benign metastasizing leiomyomas was equivalent to that for the leiomyomas and statistically less than that for the leiomyosarcomas. The mean index was 2.3% (range: 0.9% to 8.8%) for the leiomyomas and 3.4% (range: 0.7% to 8.1%) for the benign metastasizing leiomyomas compared with 28.6% (range: 14.4% to 62.0%) for the leiomyosarcomas (P<0.025). The miRNA, miR-221, which has been associated with a variety of cancers, was detected by in situ hybridization in 13/15 leiomyosarcomas, 0/8 leiomyomas, and 0/10 benign metastasizing leiomyomas. In conclusion, benign metastasizing leiomyomas are indeed most likely benign lesions, and up-regulation of miR-221 expression is an accurate way to differentiate leiomyosarcoma from benign metastasizing leiomyoma. SN - 1533-4066 UR - https://www.unboundmedicine.com/medline/citation/18382364/Benign_metastasizing_leiomyoma_of_the_lung:_clinicopathologic_immunohistochemical_and_micro_RNA_analyses_ L2 - http://dx.doi.org/10.1097/PDM.0b013e31815aca19 DB - PRIME DP - Unbound Medicine ER -