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Inhibition of the unaffected motor cortex by 1 Hz repetitive transcranical magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke.
J Rehabil Med. 2008 Apr; 40(4):298-303.JR

Abstract

OBJECTIVE

Recent reports demonstrated that low-frequency repetitive transcranial magnetic stimulation (rTMS) over the unaffected hemisphere improved the affected hand function in chronic stroke patients. We investigated whether 1 Hz rTMS improved the motor learning of the affected hand in patients after stroke.

DESIGN

A double-blind study.

PATIENTS

Twenty patients with chronic subcortical stroke.

METHODS

The patients were randomly assigned to receive either a sub-threshold rTMS over the unaffected hemisphere (1 Hz, 25 minutes) or sham stimulation, and all patients performed a pinching task after stimulation. We evaluated the motor function of the affected hand and the excitatory and inhibitory function of the affected motor cortex by transcranial magnetic stimulation.

RESULTS

Compared with sham stimulation, rTMS induced an increase in the excitability of the affected motor cortex(p < 0.001) and an improvement in acceleration of the affected hand (p = 0.006). Moreover, the effect of motor training on pinch force was enhanced by rTMS (p < 0.001). These improvement in the motor function lasted for one week after rTMS and motor training (p < 0.001).

CONCLUSION

rTMS improved the motor learning of the affected hand in patients after stroke; thus, it can apply as anew rehabilitation strategy for patients after stroke.

Authors+Show Affiliations

Department of Rehabilitation Medicine , Hospital of Hokkaido University, Sapporo, Japan. naoyuki@med.hokudai.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18382826

Citation

Takeuchi, Naoyuki, et al. "Inhibition of the Unaffected Motor Cortex By 1 Hz Repetitive Transcranical Magnetic Stimulation Enhances Motor Performance and Training Effect of the Paretic Hand in Patients With Chronic Stroke." Journal of Rehabilitation Medicine, vol. 40, no. 4, 2008, pp. 298-303.
Takeuchi N, Tada T, Toshima M, et al. Inhibition of the unaffected motor cortex by 1 Hz repetitive transcranical magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke. J Rehabil Med. 2008;40(4):298-303.
Takeuchi, N., Tada, T., Toshima, M., Chuma, T., Matsuo, Y., & Ikoma, K. (2008). Inhibition of the unaffected motor cortex by 1 Hz repetitive transcranical magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke. Journal of Rehabilitation Medicine, 40(4), 298-303. https://doi.org/10.2340/16501977-0181
Takeuchi N, et al. Inhibition of the Unaffected Motor Cortex By 1 Hz Repetitive Transcranical Magnetic Stimulation Enhances Motor Performance and Training Effect of the Paretic Hand in Patients With Chronic Stroke. J Rehabil Med. 2008;40(4):298-303. PubMed PMID: 18382826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of the unaffected motor cortex by 1 Hz repetitive transcranical magnetic stimulation enhances motor performance and training effect of the paretic hand in patients with chronic stroke. AU - Takeuchi,Naoyuki, AU - Tada,Takeo, AU - Toshima,Masahiko, AU - Chuma,Takayo, AU - Matsuo,Yuichiro, AU - Ikoma,Katsunori, PY - 2008/4/3/pubmed PY - 2008/6/3/medline PY - 2008/4/3/entrez SP - 298 EP - 303 JF - Journal of rehabilitation medicine JO - J Rehabil Med VL - 40 IS - 4 N2 - OBJECTIVE: Recent reports demonstrated that low-frequency repetitive transcranial magnetic stimulation (rTMS) over the unaffected hemisphere improved the affected hand function in chronic stroke patients. We investigated whether 1 Hz rTMS improved the motor learning of the affected hand in patients after stroke. DESIGN: A double-blind study. PATIENTS: Twenty patients with chronic subcortical stroke. METHODS: The patients were randomly assigned to receive either a sub-threshold rTMS over the unaffected hemisphere (1 Hz, 25 minutes) or sham stimulation, and all patients performed a pinching task after stimulation. We evaluated the motor function of the affected hand and the excitatory and inhibitory function of the affected motor cortex by transcranial magnetic stimulation. RESULTS: Compared with sham stimulation, rTMS induced an increase in the excitability of the affected motor cortex(p < 0.001) and an improvement in acceleration of the affected hand (p = 0.006). Moreover, the effect of motor training on pinch force was enhanced by rTMS (p < 0.001). These improvement in the motor function lasted for one week after rTMS and motor training (p < 0.001). CONCLUSION: rTMS improved the motor learning of the affected hand in patients after stroke; thus, it can apply as anew rehabilitation strategy for patients after stroke. SN - 1650-1977 UR - https://www.unboundmedicine.com/medline/citation/18382826/Inhibition_of_the_unaffected_motor_cortex_by_1_Hz_repetitive_transcranical_magnetic_stimulation_enhances_motor_performance_and_training_effect_of_the_paretic_hand_in_patients_with_chronic_stroke_ L2 - https://www.medicaljournals.se/jrm/content/abstract/10.2340/16501977-0181 DB - PRIME DP - Unbound Medicine ER -