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Differences in low-grade chronic inflammation and insulin resistance in women with previous gestational diabetes mellitus and women with polycystic ovary syndrome.
Gynecol Endocrinol 2008; 24(4):199-206GE

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) are both characterized by an increase in insulin resistance. Our goal in the present study was to measure insulin resistance (as estimated by homeostasis model assessment, sex hormone-binding globulin (SHBG) and adiponectin concentrations) and parameters of low-grade inflammation in non-diabetic, non-hyperandrogenic ovulatory women with previous GDM (pGDM) and in non-diabetic women with classic PCOS, characterized by hyperandrogenism and oligo/anovulation.

PATIENTS AND DESIGN

We evaluated 20 women with PCOS, 18 women with pGDM and 19 controls, all matched according to body mass index (BMI). Fasting blood samples were drawn in all women 3-6 days after spontaneous or dydrogesterone-induced withdrawal bleeding. Body fat distribution was assessed using dual-energy X-ray absorptiometry in all women.

RESULTS

After adjusting for age and percent body fat, measures of insulin resistance such as SHBG and adiponectin concentrations were decreased and central obesity was increased in women with PCOS and pGDM compared with controls (all p < 0.05). Parameters of low-grade inflammation such as serum tumor necrosis factor-alpha and highly sensitive C-reactive protein concentrations, white blood cell and neutrophil count were increased only in women with PCOS compared with BMI-matched controls (all p < 0.05).

CONCLUSIONS

Certain markers of insulin resistance are increased in both women with PCOS and women with pGDM, while low-grade inflammation is increased only in PCOS. PCOS and GDM might represent specific phenotypes of one disease entity with an increased risk of cardiovascular disease, whereby women with PCOS demonstrate an augmented cardiovascular risk profile.

Authors+Show Affiliations

Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Basel, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18382906

Citation

Thomann, Robert, et al. "Differences in Low-grade Chronic Inflammation and Insulin Resistance in Women With Previous Gestational Diabetes Mellitus and Women With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 24, no. 4, 2008, pp. 199-206.
Thomann R, Rossinelli N, Keller U, et al. Differences in low-grade chronic inflammation and insulin resistance in women with previous gestational diabetes mellitus and women with polycystic ovary syndrome. Gynecol Endocrinol. 2008;24(4):199-206.
Thomann, R., Rossinelli, N., Keller, U., Tirri, B. F., De Geyter, C., Ruiz, J., ... Puder, J. J. (2008). Differences in low-grade chronic inflammation and insulin resistance in women with previous gestational diabetes mellitus and women with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 24(4), pp. 199-206. doi:10.1080/09513590801893398.
Thomann R, et al. Differences in Low-grade Chronic Inflammation and Insulin Resistance in Women With Previous Gestational Diabetes Mellitus and Women With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2008;24(4):199-206. PubMed PMID: 18382906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in low-grade chronic inflammation and insulin resistance in women with previous gestational diabetes mellitus and women with polycystic ovary syndrome. AU - Thomann,Robert, AU - Rossinelli,Nadia, AU - Keller,Ulrich, AU - Tirri,Brigitte Frey, AU - De Geyter,Christian, AU - Ruiz,Juan, AU - Kränzlin,Marius, AU - Puder,Jardena J, PY - 2008/4/3/pubmed PY - 2008/9/23/medline PY - 2008/4/3/entrez SP - 199 EP - 206 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 24 IS - 4 N2 - BACKGROUND: Polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) are both characterized by an increase in insulin resistance. Our goal in the present study was to measure insulin resistance (as estimated by homeostasis model assessment, sex hormone-binding globulin (SHBG) and adiponectin concentrations) and parameters of low-grade inflammation in non-diabetic, non-hyperandrogenic ovulatory women with previous GDM (pGDM) and in non-diabetic women with classic PCOS, characterized by hyperandrogenism and oligo/anovulation. PATIENTS AND DESIGN: We evaluated 20 women with PCOS, 18 women with pGDM and 19 controls, all matched according to body mass index (BMI). Fasting blood samples were drawn in all women 3-6 days after spontaneous or dydrogesterone-induced withdrawal bleeding. Body fat distribution was assessed using dual-energy X-ray absorptiometry in all women. RESULTS: After adjusting for age and percent body fat, measures of insulin resistance such as SHBG and adiponectin concentrations were decreased and central obesity was increased in women with PCOS and pGDM compared with controls (all p < 0.05). Parameters of low-grade inflammation such as serum tumor necrosis factor-alpha and highly sensitive C-reactive protein concentrations, white blood cell and neutrophil count were increased only in women with PCOS compared with BMI-matched controls (all p < 0.05). CONCLUSIONS: Certain markers of insulin resistance are increased in both women with PCOS and women with pGDM, while low-grade inflammation is increased only in PCOS. PCOS and GDM might represent specific phenotypes of one disease entity with an increased risk of cardiovascular disease, whereby women with PCOS demonstrate an augmented cardiovascular risk profile. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/18382906/Differences_in_low_grade_chronic_inflammation_and_insulin_resistance_in_women_with_previous_gestational_diabetes_mellitus_and_women_with_polycystic_ovary_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590801893398 DB - PRIME DP - Unbound Medicine ER -