TY - JOUR T1 - Coupling of solid-phase microextraction continuous bed (monolithic) capillaries with capillary zone electrophoresis for direct analysis of drugs in biological fluids. AU - Jarmalaviciene,Reda, AU - Szumski,Michał, AU - Kornysova,Olga, AU - Kłodzińska,Ewa, AU - Westerlund,Douglas, AU - Krawczyk,Stanislas, AU - Mickevicius,Donatas, AU - Buszewski,Bogusław, AU - Maruska,Audrius, PY - 2008/4/3/pubmed PY - 2008/8/6/medline PY - 2008/4/3/entrez SP - 1753 EP - 60 JF - Electrophoresis JO - Electrophoresis VL - 29 IS - 8 N2 - Hyperlink robust biocompatible solid-phase microextraction (SPME) devices were prepared using continuous bed (monolithic) restricted-access media (RAM) as the SPME capillary insert. The RAM-based SPME approach was able to simultaneously separate proteins from a biological sample, while directly extracting the active components of caffeine, paracetamol and acetylsalicylic acid from the drug NeoCitramonum. The devices were interfaced with a CZE system and fully automated analysis for sample preconcentration, desorption, separation and quantification of analytes was evaluated. Comparative study of in-line coupled SPME-CZE using RAM and RP capillary inserts was carried out. Using an SPME (RAM) insert, the calculated caffeine, paracetamol and acetylsalicylic acid LODs in a bovine plasma sample were 0.3, 0.8 and 1.9 ng/mL, respectively. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/18383020/Coupling_of_solid_phase_microextraction_continuous_bed__monolithic__capillaries_with_capillary_zone_electrophoresis_for_direct_analysis_of_drugs_in_biological_fluids_ DB - PRIME DP - Unbound Medicine ER -