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Polymorphisms of the human platelet alloantigens HPA-1, HPA-2, HPA-3, and HPA-4 in ischemic stroke.
Am J Hematol. 2008 Jul; 83(7):570-3.AJ

Abstract

Polymorphism in human platelet antigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa), and HPA-5 (GPIa/IIa) was investigated in 329 stroke patients and 444 matched control subjects. HPA genotyping was done by PCR-SSP method. Lower HPA-1a (P < 0.001) and higher HPA-1b (P < 0.001) allele frequencies were seen in patients than control subjects, and homozygosity for HPA-1b (P < 0.001) alleles was more prevalent in stroke cases than in controls. The allele and genotype distributions of the other HPA polymorphic variants were similar between cases and controls. Select HPA combined genotypes comprising the 2121 (Pc = 0.008) and 2221 (Pc = 0.018) genotypes, which were positively associated, and the 1111 (Pc < 0.001), which was negatively associated with stroke, thereby conferred a disease susceptibility and protective nature to these genotype combinations. Multivariate analysis confirmed the negative association of the 1111 (P < 0.001) and the positive association of the 2121 (P = 0.017) combined genotypes with stroke, after adjustment for a number of covariates. This is the first evidence demonstrating differential association of the common 4 HPA gene variants and specific HPA genotype combinations with stroke.

Authors+Show Affiliations

Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18383324

Citation

Saidi, Sarra, et al. "Polymorphisms of the Human Platelet Alloantigens HPA-1, HPA-2, HPA-3, and HPA-4 in Ischemic Stroke." American Journal of Hematology, vol. 83, no. 7, 2008, pp. 570-3.
Saidi S, Mahjoub T, Slamia LB, et al. Polymorphisms of the human platelet alloantigens HPA-1, HPA-2, HPA-3, and HPA-4 in ischemic stroke. Am J Hematol. 2008;83(7):570-3.
Saidi, S., Mahjoub, T., Slamia, L. B., Ammou, S. B., Al-Subaie, A. M., & Almawi, W. Y. (2008). Polymorphisms of the human platelet alloantigens HPA-1, HPA-2, HPA-3, and HPA-4 in ischemic stroke. American Journal of Hematology, 83(7), 570-3. https://doi.org/10.1002/ajh.21171
Saidi S, et al. Polymorphisms of the Human Platelet Alloantigens HPA-1, HPA-2, HPA-3, and HPA-4 in Ischemic Stroke. Am J Hematol. 2008;83(7):570-3. PubMed PMID: 18383324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphisms of the human platelet alloantigens HPA-1, HPA-2, HPA-3, and HPA-4 in ischemic stroke. AU - Saidi,Sarra, AU - Mahjoub,Touhami, AU - Slamia,Lamia B, AU - Ammou,Sofyan B, AU - Al-Subaie,Abeer M, AU - Almawi,Wassim Y, PY - 2008/4/3/pubmed PY - 2008/7/19/medline PY - 2008/4/3/entrez SP - 570 EP - 3 JF - American journal of hematology JO - Am. J. Hematol. VL - 83 IS - 7 N2 - Polymorphism in human platelet antigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa), and HPA-5 (GPIa/IIa) was investigated in 329 stroke patients and 444 matched control subjects. HPA genotyping was done by PCR-SSP method. Lower HPA-1a (P < 0.001) and higher HPA-1b (P < 0.001) allele frequencies were seen in patients than control subjects, and homozygosity for HPA-1b (P < 0.001) alleles was more prevalent in stroke cases than in controls. The allele and genotype distributions of the other HPA polymorphic variants were similar between cases and controls. Select HPA combined genotypes comprising the 2121 (Pc = 0.008) and 2221 (Pc = 0.018) genotypes, which were positively associated, and the 1111 (Pc < 0.001), which was negatively associated with stroke, thereby conferred a disease susceptibility and protective nature to these genotype combinations. Multivariate analysis confirmed the negative association of the 1111 (P < 0.001) and the positive association of the 2121 (P = 0.017) combined genotypes with stroke, after adjustment for a number of covariates. This is the first evidence demonstrating differential association of the common 4 HPA gene variants and specific HPA genotype combinations with stroke. SN - 1096-8652 UR - https://www.unboundmedicine.com/medline/citation/18383324/Polymorphisms_of_the_human_platelet_alloantigens_HPA_1_HPA_2_HPA_3_and_HPA_4_in_ischemic_stroke_ L2 - https://doi.org/10.1002/ajh.21171 DB - PRIME DP - Unbound Medicine ER -