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Evaluation of the in vitro effect of Nigella sativa aqueous extract on Blastocystis hominis isolates.
J Egypt Soc Parasitol. 2007 Dec; 37(3):801-13.JE

Abstract

The effect of Nigella sativa aqueous extract was evaluated against the in vitro growth of 2 different isolates of the intestinal protozoan parasite Blastocystis hominis. Different concentrations (10, 100, 500 microg/ml) of Nigella aqueous extract and metronidazole, an active standard drug for B. hominis, were incubated with B. hominis isolates in culture media at 37 degrees C. Their possible effect on B. hominnis living cell count (LCC) was assessed on Day 1, 3 & 6. The aqueous extract of N. sativa at concentrations of 100 and 500 microg/ml showed a potent lethal effect on both B. homninis isolates, but with different extent. There is no significant difference between the inhibitory effect of N. sativa and metronidazole on the LCC on the 6th day. On assessment of living cell rate (LCR) which calculate percentage rate of living cell, N. sativa at 500 microg/ml concentration has a significant inhibitory effect on both isolates. So, it is considered as the most active concentration of Nigella aqueous extract. These results prove that N. sativa aqueous extract could be useful in the treatment of B. hominis.

Authors+Show Affiliations

Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt. hasa66@hotmail.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18383782

Citation

El Wakil, Shala S.. "Evaluation of the in Vitro Effect of Nigella Sativa Aqueous Extract On Blastocystis Hominis Isolates." Journal of the Egyptian Society of Parasitology, vol. 37, no. 3, 2007, pp. 801-13.
El Wakil SS. Evaluation of the in vitro effect of Nigella sativa aqueous extract on Blastocystis hominis isolates. J Egypt Soc Parasitol. 2007;37(3):801-13.
El Wakil, S. S. (2007). Evaluation of the in vitro effect of Nigella sativa aqueous extract on Blastocystis hominis isolates. Journal of the Egyptian Society of Parasitology, 37(3), 801-13.
El Wakil SS. Evaluation of the in Vitro Effect of Nigella Sativa Aqueous Extract On Blastocystis Hominis Isolates. J Egypt Soc Parasitol. 2007;37(3):801-13. PubMed PMID: 18383782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the in vitro effect of Nigella sativa aqueous extract on Blastocystis hominis isolates. A1 - El Wakil,Shala S, PY - 2008/4/4/pubmed PY - 2008/5/13/medline PY - 2008/4/4/entrez SP - 801 EP - 13 JF - Journal of the Egyptian Society of Parasitology JO - J Egypt Soc Parasitol VL - 37 IS - 3 N2 - The effect of Nigella sativa aqueous extract was evaluated against the in vitro growth of 2 different isolates of the intestinal protozoan parasite Blastocystis hominis. Different concentrations (10, 100, 500 microg/ml) of Nigella aqueous extract and metronidazole, an active standard drug for B. hominis, were incubated with B. hominis isolates in culture media at 37 degrees C. Their possible effect on B. hominnis living cell count (LCC) was assessed on Day 1, 3 & 6. The aqueous extract of N. sativa at concentrations of 100 and 500 microg/ml showed a potent lethal effect on both B. homninis isolates, but with different extent. There is no significant difference between the inhibitory effect of N. sativa and metronidazole on the LCC on the 6th day. On assessment of living cell rate (LCR) which calculate percentage rate of living cell, N. sativa at 500 microg/ml concentration has a significant inhibitory effect on both isolates. So, it is considered as the most active concentration of Nigella aqueous extract. These results prove that N. sativa aqueous extract could be useful in the treatment of B. hominis. SN - 1110-0583 UR - https://www.unboundmedicine.com/medline/citation/18383782/Evaluation_of_the_in_vitro_effect_of_Nigella_sativa_aqueous_extract_on_Blastocystis_hominis_isolates_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -