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Wilms' tumor 1 protein and focal adhesion kinase mediate keratinocyte growth factor signaling in breast cancer cells.
Anticancer Res. 2008 Jan-Feb; 28(1A):133-7.AR

Abstract

BACKGROUND

Keratinocyte growth factor (KGF) has been shown to induce breast cancer metastasis in animal models. cDNA microarrays have revealed that KGF increased Wilms tumor 1 (WT1) and focal adhesion kinase (FAK) expression in breast cancer cells. The role of WT1 and FAK in KGF signaling was investigated.

MATERIALS AND METHODS

A cell culture wounding model was used to study the effects of WT1 and FAK down-regulation on KGF-induced proliferation and motility in breast cancer cells.

RESULTS

WT1 down-regulation inhibited KGF-mediated proliferation and motility of breast cancer cells, while FAK down-regulation inhibited proliferation, but had no significant effect on cell motility. WT1 down-regulation, but not FAK down-regulation, led to Erk1,2 inactivation.

CONCLUSION

KGF-mediated signaling employs WT1 and FAK to regulate breast cancer cell proliferation and motility and may represent therapeutic targets for the prevention of breast cancer progression.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, University of Oklahoma, Health Sciences Center, Oklahoma City, OK, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18383836

Citation

Zang, Xiao-Ping, et al. "Wilms' Tumor 1 Protein and Focal Adhesion Kinase Mediate Keratinocyte Growth Factor Signaling in Breast Cancer Cells." Anticancer Research, vol. 28, no. 1A, 2008, pp. 133-7.
Zang XP, Pento JT, Tari AM. Wilms' tumor 1 protein and focal adhesion kinase mediate keratinocyte growth factor signaling in breast cancer cells. Anticancer Res. 2008;28(1A):133-7.
Zang, X. P., Pento, J. T., & Tari, A. M. (2008). Wilms' tumor 1 protein and focal adhesion kinase mediate keratinocyte growth factor signaling in breast cancer cells. Anticancer Research, 28(1A), 133-7.
Zang XP, Pento JT, Tari AM. Wilms' Tumor 1 Protein and Focal Adhesion Kinase Mediate Keratinocyte Growth Factor Signaling in Breast Cancer Cells. Anticancer Res. 2008 Jan-Feb;28(1A):133-7. PubMed PMID: 18383836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Wilms' tumor 1 protein and focal adhesion kinase mediate keratinocyte growth factor signaling in breast cancer cells. AU - Zang,Xiao-Ping, AU - Pento,J Thomas, AU - Tari,Ana M, PY - 2008/4/4/pubmed PY - 2008/4/11/medline PY - 2008/4/4/entrez SP - 133 EP - 7 JF - Anticancer research JO - Anticancer Res VL - 28 IS - 1A N2 - BACKGROUND: Keratinocyte growth factor (KGF) has been shown to induce breast cancer metastasis in animal models. cDNA microarrays have revealed that KGF increased Wilms tumor 1 (WT1) and focal adhesion kinase (FAK) expression in breast cancer cells. The role of WT1 and FAK in KGF signaling was investigated. MATERIALS AND METHODS: A cell culture wounding model was used to study the effects of WT1 and FAK down-regulation on KGF-induced proliferation and motility in breast cancer cells. RESULTS: WT1 down-regulation inhibited KGF-mediated proliferation and motility of breast cancer cells, while FAK down-regulation inhibited proliferation, but had no significant effect on cell motility. WT1 down-regulation, but not FAK down-regulation, led to Erk1,2 inactivation. CONCLUSION: KGF-mediated signaling employs WT1 and FAK to regulate breast cancer cell proliferation and motility and may represent therapeutic targets for the prevention of breast cancer progression. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/18383836/Wilms'_tumor_1_protein_and_focal_adhesion_kinase_mediate_keratinocyte_growth_factor_signaling_in_breast_cancer_cells_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18383836 DB - PRIME DP - Unbound Medicine ER -