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A study of the properties of tablets made of directly compressible maltose.
Ceska Slov Farm. 2008 Jan; 57(1):21-7.CS

Abstract

The paper deals with the study of the strength and disintegration time of tablets made of directly compressible maltose Advantose 100. It studies the differences of the effects of two types of lubricants, magnesium stearate and sodium stearylfumarate, on the above-mentioned properties, and it also tests the mixtures of the substance with microcrystalline cellulose Vivapur 102 in a ratio of 1:1 and with ascorbic and acetylsalicylic acids. The compacts are obtained by using three compression forces, excepting mixtures with active ingredients, where one compression force is used. In the compression forces of 6 and 8 kN, no statistically significant difference was found in the intervention of the lubricants into the strength of the compacts made of Advantose 100, only in the compression force of 10 kN Pruv decreased the strength more than stearate. The mixture of Advantose 100 and Vivapur 102 yielded the strongest tablets, an addition of Pruv to it decreased the strength of compacts more than stearate. The periods of disintegration time of Advantose compacts as well as those of the mixture of dry binders were longer with an addition of Pruv. The compacts with acetylsalicylic acid possessed higher strength and a longer period of disintegration than those with ascorbic acid. There was no statistically significant difference within the type of the lubricant employed, both in the case of Advantose 100 and its mixture with Vivapur 102, between the values of strength of the compacts with acetylsalicylic acid.

Authors+Show Affiliations

Muzíková J
Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic, Department of Pharmaceutical Technology. muzikova@faf.cuni.cz
Balhárková J
No affiliation info available

MeSH

CelluloseCompressive StrengthLubricantsMaltosePharmaceutic AidsTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18383920

Citation

Muzíková, J, and J Balhárková. "A Study of the Properties of Tablets Made of Directly Compressible Maltose." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 57, no. 1, 2008, pp. 21-7.
Muzíková J, Balhárková J. A study of the properties of tablets made of directly compressible maltose. Ceska Slov Farm. 2008;57(1):21-7.
Muzíková, J., & Balhárková, J. (2008). A study of the properties of tablets made of directly compressible maltose. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 57(1), 21-7.
Muzíková J, Balhárková J. A Study of the Properties of Tablets Made of Directly Compressible Maltose. Ceska Slov Farm. 2008;57(1):21-7. PubMed PMID: 18383920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of the properties of tablets made of directly compressible maltose. AU - Muzíková,J, AU - Balhárková,J, PY - 2008/4/4/pubmed PY - 2008/5/21/medline PY - 2008/4/4/entrez SP - 21 EP - 7 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 57 IS - 1 N2 - The paper deals with the study of the strength and disintegration time of tablets made of directly compressible maltose Advantose 100. It studies the differences of the effects of two types of lubricants, magnesium stearate and sodium stearylfumarate, on the above-mentioned properties, and it also tests the mixtures of the substance with microcrystalline cellulose Vivapur 102 in a ratio of 1:1 and with ascorbic and acetylsalicylic acids. The compacts are obtained by using three compression forces, excepting mixtures with active ingredients, where one compression force is used. In the compression forces of 6 and 8 kN, no statistically significant difference was found in the intervention of the lubricants into the strength of the compacts made of Advantose 100, only in the compression force of 10 kN Pruv decreased the strength more than stearate. The mixture of Advantose 100 and Vivapur 102 yielded the strongest tablets, an addition of Pruv to it decreased the strength of compacts more than stearate. The periods of disintegration time of Advantose compacts as well as those of the mixture of dry binders were longer with an addition of Pruv. The compacts with acetylsalicylic acid possessed higher strength and a longer period of disintegration than those with ascorbic acid. There was no statistically significant difference within the type of the lubricant employed, both in the case of Advantose 100 and its mixture with Vivapur 102, between the values of strength of the compacts with acetylsalicylic acid. SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/18383920/A_study_of_the_properties_of_tablets_made_of_directly_compressible_maltose_ DB - PRIME DP - Unbound Medicine ER -