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Is there any place for alimentary probiotics, prebiotics or synbiotics, for patients with inflammatory bowel disease?
Mol Nutr Food Res 2008; 52(8):906-12MN

Abstract

The pathogenesis of inflammatory bowel disease (IBD) involves an interaction between genetically determined host susceptibility, dysregulated immune response, and the enteric microbiota. Ecological treatments including probiotics, prebiotics, and synbiotics are actively studied in Crohn's disease (CD), ulcerative colitis (UC) and pouchitis. We review herein the literature on the rational use of probiotics in IBD considering efficacy (as evaluated in randomized controlled trials), mechanisms of action and safety issues. A probiotic effect is strictly restricted to one defined strain and cannot be generalized from one to another. There is evidence of efficacy of some probiotic drugs in pouchitis (VSL#3), and in the prevention of recurrence of UC (Escherichia coli Nissle 1917). However, the evidence for efficacy of probiotic drugs in CD is still low as well as that of dietary ecological treatments. Despite an ecological (hopefully nutritional) treatment of IBD is promising, many questions remain unanswered and further clinical and fundamental studies are needed.

Authors+Show Affiliations

AP-HP, Hôpital Saint-Antoine, Gastroenterology and Nutrition Department, University Pierre et Marie Curie, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18384087

Citation

Seksik, Philippe, et al. "Is There Any Place for Alimentary Probiotics, Prebiotics or Synbiotics, for Patients With Inflammatory Bowel Disease?" Molecular Nutrition & Food Research, vol. 52, no. 8, 2008, pp. 906-12.
Seksik P, Dray X, Sokol H, et al. Is there any place for alimentary probiotics, prebiotics or synbiotics, for patients with inflammatory bowel disease? Mol Nutr Food Res. 2008;52(8):906-12.
Seksik, P., Dray, X., Sokol, H., & Marteau, P. (2008). Is there any place for alimentary probiotics, prebiotics or synbiotics, for patients with inflammatory bowel disease? Molecular Nutrition & Food Research, 52(8), pp. 906-12. doi:10.1002/mnfr.200700147.
Seksik P, et al. Is There Any Place for Alimentary Probiotics, Prebiotics or Synbiotics, for Patients With Inflammatory Bowel Disease. Mol Nutr Food Res. 2008;52(8):906-12. PubMed PMID: 18384087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there any place for alimentary probiotics, prebiotics or synbiotics, for patients with inflammatory bowel disease? AU - Seksik,Philippe, AU - Dray,Xavier, AU - Sokol,Harry, AU - Marteau,Philippe, PY - 2008/4/4/pubmed PY - 2008/10/29/medline PY - 2008/4/4/entrez SP - 906 EP - 12 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 52 IS - 8 N2 - The pathogenesis of inflammatory bowel disease (IBD) involves an interaction between genetically determined host susceptibility, dysregulated immune response, and the enteric microbiota. Ecological treatments including probiotics, prebiotics, and synbiotics are actively studied in Crohn's disease (CD), ulcerative colitis (UC) and pouchitis. We review herein the literature on the rational use of probiotics in IBD considering efficacy (as evaluated in randomized controlled trials), mechanisms of action and safety issues. A probiotic effect is strictly restricted to one defined strain and cannot be generalized from one to another. There is evidence of efficacy of some probiotic drugs in pouchitis (VSL#3), and in the prevention of recurrence of UC (Escherichia coli Nissle 1917). However, the evidence for efficacy of probiotic drugs in CD is still low as well as that of dietary ecological treatments. Despite an ecological (hopefully nutritional) treatment of IBD is promising, many questions remain unanswered and further clinical and fundamental studies are needed. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/18384087/Is_there_any_place_for_alimentary_probiotics_prebiotics_or_synbiotics_for_patients_with_inflammatory_bowel_disease L2 - https://doi.org/10.1002/mnfr.200700147 DB - PRIME DP - Unbound Medicine ER -