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Neuroticism as a mediator of treatment response to SSRIs in major depressive disorder.
J Affect Disord. 2008 Nov; 111(1):67-73.JA

Abstract

BACKGROUND

Serotonin function has been implicated in both major depressive disorder and neuroticism. In the current investigation, we examined the hypothesis that any change in depression severity is mediated through the reduction of neuroticism, but only for those compounds which target serotonin receptors.

METHODS

Ninety-three outpatients in the midst of a major depressive episode received one of three antidepressant medications, classified into two broad types: selective serotonin reuptake inhibitors (SSRIs) and non-SSRIs (i.e. reversible monoamine oxidase inhibitors [RIMAs] and noradrenergic and dopaminergic reuptake blockers [NDMs]). Patients completed the Hamilton Rating Scale for Depression, Beck Depression Inventory II and Revised NEO Personality Inventory prior to and following approximately 16 weeks of treatment. Structural equation modeling was used to test two models: a mediation model, in which neuroticism change is the mechanism by which SSRIs exert a therapeutic effect upon depressive symptoms, and a complication model, in which neuroticism change is a mere epiphenomenon of depression reduction in response to SSRIs.

RESULTS

The mediation model provided a good fit to the data; the complication model did not. Patients treated with SSRIs demonstrated greater neuroticism change than those treated with non-SSRIs, and greater neuroticism change was associated with greater depressive symptom change. These effects held for both self-reported and clinician-rated depressive symptom severity.

LIMITATIONS

Replication within a randomized control trial with multiple assessment periods is required.

CONCLUSION

Neuroticism mediates changes in depression in response to treatment with SSRIs, such that any treatment effect of SSRIs occurs through neuroticism reduction.

Authors+Show Affiliations

University of Toronto, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18384882

Citation

Quilty, Lena C., et al. "Neuroticism as a Mediator of Treatment Response to SSRIs in Major Depressive Disorder." Journal of Affective Disorders, vol. 111, no. 1, 2008, pp. 67-73.
Quilty LC, Meusel LA, Bagby RM. Neuroticism as a mediator of treatment response to SSRIs in major depressive disorder. J Affect Disord. 2008;111(1):67-73.
Quilty, L. C., Meusel, L. A., & Bagby, R. M. (2008). Neuroticism as a mediator of treatment response to SSRIs in major depressive disorder. Journal of Affective Disorders, 111(1), 67-73. https://doi.org/10.1016/j.jad.2008.02.006
Quilty LC, Meusel LA, Bagby RM. Neuroticism as a Mediator of Treatment Response to SSRIs in Major Depressive Disorder. J Affect Disord. 2008;111(1):67-73. PubMed PMID: 18384882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroticism as a mediator of treatment response to SSRIs in major depressive disorder. AU - Quilty,Lena C, AU - Meusel,Liesel-Ann C, AU - Bagby,R Michael, Y1 - 2008/04/02/ PY - 2007/11/14/received PY - 2008/01/07/revised PY - 2008/02/06/accepted PY - 2008/4/4/pubmed PY - 2008/12/17/medline PY - 2008/4/4/entrez SP - 67 EP - 73 JF - Journal of affective disorders JO - J Affect Disord VL - 111 IS - 1 N2 - BACKGROUND: Serotonin function has been implicated in both major depressive disorder and neuroticism. In the current investigation, we examined the hypothesis that any change in depression severity is mediated through the reduction of neuroticism, but only for those compounds which target serotonin receptors. METHODS: Ninety-three outpatients in the midst of a major depressive episode received one of three antidepressant medications, classified into two broad types: selective serotonin reuptake inhibitors (SSRIs) and non-SSRIs (i.e. reversible monoamine oxidase inhibitors [RIMAs] and noradrenergic and dopaminergic reuptake blockers [NDMs]). Patients completed the Hamilton Rating Scale for Depression, Beck Depression Inventory II and Revised NEO Personality Inventory prior to and following approximately 16 weeks of treatment. Structural equation modeling was used to test two models: a mediation model, in which neuroticism change is the mechanism by which SSRIs exert a therapeutic effect upon depressive symptoms, and a complication model, in which neuroticism change is a mere epiphenomenon of depression reduction in response to SSRIs. RESULTS: The mediation model provided a good fit to the data; the complication model did not. Patients treated with SSRIs demonstrated greater neuroticism change than those treated with non-SSRIs, and greater neuroticism change was associated with greater depressive symptom change. These effects held for both self-reported and clinician-rated depressive symptom severity. LIMITATIONS: Replication within a randomized control trial with multiple assessment periods is required. CONCLUSION: Neuroticism mediates changes in depression in response to treatment with SSRIs, such that any treatment effect of SSRIs occurs through neuroticism reduction. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/18384882/Neuroticism_as_a_mediator_of_treatment_response_to_SSRIs_in_major_depressive_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(08)00073-6 DB - PRIME DP - Unbound Medicine ER -