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Ethnic variability in retinal vessel caliber: a potential source of measurement error from ocular pigmentation?--the Sydney Childhood Eye Study.
Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1362-6.IO

Abstract

PURPOSE

To describe the effects of ethnicity and iris color on measurement of retinal vascular caliber.

METHODS

The Sydney Childhood Eye Study (SCES) examined 1740 6-year-old children from 34 randomly selected Sydney schools during 2003 and 2004. Retinal arteriolar and venular calibers (central retinal arteriolar [CRAE] and central retinal venular [CRVE] equivalents) were measured from retinal photographs by a standardized computer-assisted

METHOD

Associations of retinal vascular caliber with ethnicity and iris color were analyzed.

RESULTS

Of the total participants, 1612 (92.6%) had gradable retinal photographs. CRAE and CRVE were normally distributed, with means (SD) of 163.2 (14.0) and 227.3 (18.3) microm, respectively. Both arteriolar and venular calibers were substantially wider in the East Asian than in the Caucasian children (CRAE, 171.5 mum vs. 160.5 mum; and CRVE, 240.5 microm vs. 222.4 microm; P < 0.0001 for both comparisons). Among the Caucasian children, darker iris color was associated with wider arteriolar and venular caliber: CRAE increased from 157.5 microm in blue eyes to 169.2 microm in dark brown eyes (P for trend < 0.0001), and CRVE increased from 218.4 microm in blue eyes to 230.0 microm in dark brown eyes (P for trend < 0.0001). Among the children with dark brown eyes, there was no significant difference in CRAE between the Caucasian and the East Asian children, although mean CRVE was still approximately 10 mum wider in the East Asian than in the Caucasian children.

CONCLUSIONS

Retinal vessel caliber was wider in the children of East Asian ethnicity. This difference was explained principally by darker iris color. Retinal pigmentation, as approximated by iris color, could be an important source of error in the measurement of retinal vessel caliber. If confirmed, this may affect comparisons of retinal vessel caliber between subjects with different ethnic backgrounds.

Authors+Show Affiliations

Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18385051

Citation

Rochtchina, Elena, et al. "Ethnic Variability in Retinal Vessel Caliber: a Potential Source of Measurement Error From Ocular Pigmentation?--the Sydney Childhood Eye Study." Investigative Ophthalmology & Visual Science, vol. 49, no. 4, 2008, pp. 1362-6.
Rochtchina E, Wang JJ, Taylor B, et al. Ethnic variability in retinal vessel caliber: a potential source of measurement error from ocular pigmentation?--the Sydney Childhood Eye Study. Invest Ophthalmol Vis Sci. 2008;49(4):1362-6.
Rochtchina, E., Wang, J. J., Taylor, B., Wong, T. Y., & Mitchell, P. (2008). Ethnic variability in retinal vessel caliber: a potential source of measurement error from ocular pigmentation?--the Sydney Childhood Eye Study. Investigative Ophthalmology & Visual Science, 49(4), 1362-6. https://doi.org/10.1167/iovs.07-0150
Rochtchina E, et al. Ethnic Variability in Retinal Vessel Caliber: a Potential Source of Measurement Error From Ocular Pigmentation?--the Sydney Childhood Eye Study. Invest Ophthalmol Vis Sci. 2008;49(4):1362-6. PubMed PMID: 18385051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethnic variability in retinal vessel caliber: a potential source of measurement error from ocular pigmentation?--the Sydney Childhood Eye Study. AU - Rochtchina,Elena, AU - Wang,Jie Jin, AU - Taylor,Bronwen, AU - Wong,Tien Y, AU - Mitchell,Paul, PY - 2008/4/4/pubmed PY - 2008/6/25/medline PY - 2008/4/4/entrez SP - 1362 EP - 6 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 49 IS - 4 N2 - PURPOSE: To describe the effects of ethnicity and iris color on measurement of retinal vascular caliber. METHODS: The Sydney Childhood Eye Study (SCES) examined 1740 6-year-old children from 34 randomly selected Sydney schools during 2003 and 2004. Retinal arteriolar and venular calibers (central retinal arteriolar [CRAE] and central retinal venular [CRVE] equivalents) were measured from retinal photographs by a standardized computer-assisted METHOD: Associations of retinal vascular caliber with ethnicity and iris color were analyzed. RESULTS: Of the total participants, 1612 (92.6%) had gradable retinal photographs. CRAE and CRVE were normally distributed, with means (SD) of 163.2 (14.0) and 227.3 (18.3) microm, respectively. Both arteriolar and venular calibers were substantially wider in the East Asian than in the Caucasian children (CRAE, 171.5 mum vs. 160.5 mum; and CRVE, 240.5 microm vs. 222.4 microm; P < 0.0001 for both comparisons). Among the Caucasian children, darker iris color was associated with wider arteriolar and venular caliber: CRAE increased from 157.5 microm in blue eyes to 169.2 microm in dark brown eyes (P for trend < 0.0001), and CRVE increased from 218.4 microm in blue eyes to 230.0 microm in dark brown eyes (P for trend < 0.0001). Among the children with dark brown eyes, there was no significant difference in CRAE between the Caucasian and the East Asian children, although mean CRVE was still approximately 10 mum wider in the East Asian than in the Caucasian children. CONCLUSIONS: Retinal vessel caliber was wider in the children of East Asian ethnicity. This difference was explained principally by darker iris color. Retinal pigmentation, as approximated by iris color, could be an important source of error in the measurement of retinal vessel caliber. If confirmed, this may affect comparisons of retinal vessel caliber between subjects with different ethnic backgrounds. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/18385051/Ethnic_variability_in_retinal_vessel_caliber:_a_potential_source_of_measurement_error_from_ocular_pigmentation__the_Sydney_Childhood_Eye_Study_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.07-0150 DB - PRIME DP - Unbound Medicine ER -