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Accommodation-related changes in monochromatic aberrations of the human eye as a function of age.
Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1736-43.IO

Abstract

PURPOSE

To investigate the relationship between accommodation and the optical aberrations of the whole human eye, as a function of age.

METHODS

Sixty healthy subjects with spherical ametropia in the range +/-3 D, astigmatism less than 1 D, corrected visual acuity of 20/18 or better, and normal findings in an ophthalmic examination were enrolled. Subjects were divided into four groups, with age ranges of 19 to 29, 30 to 39, 40 to 49, and 50 to 60 years. Monochromatic optical aberrations and pupil size were measured with a Hartmann-Shack wavefront sensor under monocular viewing conditions, without pharmacological dilation or cycloplegia. Stimulus vergences were in the range of 0 to 5 D, with an increment of 0.5 D. The change in aberration during accommodation for different groups and different pupil conditions (natural and fixed 4-mm pupil) was compared.

RESULTS

Fourth-order spherical aberration (SA) became more negative with accommodation, and the rate of this change was greater in older individuals. For natural pupil conditions, there were no significant differences between age groups in the changes of the higher-order aberrations, coma, and trefoil with accommodation. However, for a 4-mm pupil, the youngest and oldest group showed significant differences in higher order RMS (root mean square) and spherical aberration compared with the other groups. High-order RMS showed a lower increase during accommodation when the pupil accommodative miosis was taken into account (natural pupil condition) than when a fixed 4-mm pupil was used.

CONCLUSIONS

Aberrations change with accommodation and with age. SA changes more with accommodation do than other higher-order aberrations. SA becomes more negative with accommodation, and this change is larger in older individuals. Accommodative miosis is useful for ameliorating the increase in higher-order aberrations with accommodation.

Authors+Show Affiliations

Departament de Física, Universidad de Murcia, Murcia, Spain. norberto@um.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18385098

Citation

López-Gil, Norberto, et al. "Accommodation-related Changes in Monochromatic Aberrations of the Human Eye as a Function of Age." Investigative Ophthalmology & Visual Science, vol. 49, no. 4, 2008, pp. 1736-43.
López-Gil N, Fernández-Sánchez V, Legras R, et al. Accommodation-related changes in monochromatic aberrations of the human eye as a function of age. Invest Ophthalmol Vis Sci. 2008;49(4):1736-43.
López-Gil, N., Fernández-Sánchez, V., Legras, R., Montés-Micó, R., Lara, F., & Nguyen-Khoa, J. L. (2008). Accommodation-related changes in monochromatic aberrations of the human eye as a function of age. Investigative Ophthalmology & Visual Science, 49(4), 1736-43. https://doi.org/10.1167/iovs.06-0802
López-Gil N, et al. Accommodation-related Changes in Monochromatic Aberrations of the Human Eye as a Function of Age. Invest Ophthalmol Vis Sci. 2008;49(4):1736-43. PubMed PMID: 18385098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accommodation-related changes in monochromatic aberrations of the human eye as a function of age. AU - López-Gil,Norberto, AU - Fernández-Sánchez,Vicente, AU - Legras,Richard, AU - Montés-Micó,Robert, AU - Lara,Francisco, AU - Nguyen-Khoa,Jean Luc, PY - 2008/4/4/pubmed PY - 2008/6/25/medline PY - 2008/4/4/entrez SP - 1736 EP - 43 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 49 IS - 4 N2 - PURPOSE: To investigate the relationship between accommodation and the optical aberrations of the whole human eye, as a function of age. METHODS: Sixty healthy subjects with spherical ametropia in the range +/-3 D, astigmatism less than 1 D, corrected visual acuity of 20/18 or better, and normal findings in an ophthalmic examination were enrolled. Subjects were divided into four groups, with age ranges of 19 to 29, 30 to 39, 40 to 49, and 50 to 60 years. Monochromatic optical aberrations and pupil size were measured with a Hartmann-Shack wavefront sensor under monocular viewing conditions, without pharmacological dilation or cycloplegia. Stimulus vergences were in the range of 0 to 5 D, with an increment of 0.5 D. The change in aberration during accommodation for different groups and different pupil conditions (natural and fixed 4-mm pupil) was compared. RESULTS: Fourth-order spherical aberration (SA) became more negative with accommodation, and the rate of this change was greater in older individuals. For natural pupil conditions, there were no significant differences between age groups in the changes of the higher-order aberrations, coma, and trefoil with accommodation. However, for a 4-mm pupil, the youngest and oldest group showed significant differences in higher order RMS (root mean square) and spherical aberration compared with the other groups. High-order RMS showed a lower increase during accommodation when the pupil accommodative miosis was taken into account (natural pupil condition) than when a fixed 4-mm pupil was used. CONCLUSIONS: Aberrations change with accommodation and with age. SA changes more with accommodation do than other higher-order aberrations. SA becomes more negative with accommodation, and this change is larger in older individuals. Accommodative miosis is useful for ameliorating the increase in higher-order aberrations with accommodation. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/18385098/Accommodation_related_changes_in_monochromatic_aberrations_of_the_human_eye_as_a_function_of_age_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.06-0802 DB - PRIME DP - Unbound Medicine ER -