Tags

Type your tag names separated by a space and hit enter

Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice.
Kidney Int 2008; 74(2):170-9KI

Abstract

To determine whether the cardiovascular effect of 1,25(OH)(2)D is dependent on calcium and/or phosphorus, mice with targeted deletion of the 25(OH)D 1alpha-hydroxylase and their wild-type littermates were fed a normal diet or a diet to rescue the ambient serum calcium and phosphorus levels. Mice on the normal diet were treated daily with vehicle or 1,25(OH)(2)D(3) while mice on the rescue diet received vehicle, captopril or losartan. After four weeks the vehicle-treated knockout mice developed hypertension, cardiac hypertrophy and impaired cardiac function along with an up-regulation of the renin-angiotensin system in both renal and cardiac tissues. Although the serum calcium and phosphorus levels were normalized in knockout mice on the rescue diet, abnormalities in blood pressure, cardiac structure-function and the renin-angiotensin system remained. In contrast, 1,25(OH)(2)D(3) not only normalized serum calcium and phosphorus levels but also normalized blood pressure, cardiac structure-function and the renin-angiotensin system. Treatment of the knockout mice with either captopril or losartan normalized blood pressure and cardiac structure and function although renin expression remained elevated. This study shows that 1,25(OH)2D plays a protective role in the cardiovascular system by repressing the renin-angiotensin system independent of extracellular calcium or phosphorus.

Authors+Show Affiliations

The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, PR of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18385669

Citation

Zhou, Chunlei, et al. "Calcium-independent and 1,25(OH)2D3-dependent Regulation of the Renin-angiotensin System in 1alpha-hydroxylase Knockout Mice." Kidney International, vol. 74, no. 2, 2008, pp. 170-9.
Zhou C, Lu F, Cao K, et al. Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int. 2008;74(2):170-9.
Zhou, C., Lu, F., Cao, K., Xu, D., Goltzman, D., & Miao, D. (2008). Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney International, 74(2), pp. 170-9. doi:10.1038/ki.2008.101.
Zhou C, et al. Calcium-independent and 1,25(OH)2D3-dependent Regulation of the Renin-angiotensin System in 1alpha-hydroxylase Knockout Mice. Kidney Int. 2008;74(2):170-9. PubMed PMID: 18385669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. AU - Zhou,Chunlei, AU - Lu,Fengxiang, AU - Cao,Kejiang, AU - Xu,Di, AU - Goltzman,David, AU - Miao,Dengshun, Y1 - 2008/04/02/ PY - 2008/4/4/pubmed PY - 2008/8/5/medline PY - 2008/4/4/entrez SP - 170 EP - 9 JF - Kidney international JO - Kidney Int. VL - 74 IS - 2 N2 - To determine whether the cardiovascular effect of 1,25(OH)(2)D is dependent on calcium and/or phosphorus, mice with targeted deletion of the 25(OH)D 1alpha-hydroxylase and their wild-type littermates were fed a normal diet or a diet to rescue the ambient serum calcium and phosphorus levels. Mice on the normal diet were treated daily with vehicle or 1,25(OH)(2)D(3) while mice on the rescue diet received vehicle, captopril or losartan. After four weeks the vehicle-treated knockout mice developed hypertension, cardiac hypertrophy and impaired cardiac function along with an up-regulation of the renin-angiotensin system in both renal and cardiac tissues. Although the serum calcium and phosphorus levels were normalized in knockout mice on the rescue diet, abnormalities in blood pressure, cardiac structure-function and the renin-angiotensin system remained. In contrast, 1,25(OH)(2)D(3) not only normalized serum calcium and phosphorus levels but also normalized blood pressure, cardiac structure-function and the renin-angiotensin system. Treatment of the knockout mice with either captopril or losartan normalized blood pressure and cardiac structure and function although renin expression remained elevated. This study shows that 1,25(OH)2D plays a protective role in the cardiovascular system by repressing the renin-angiotensin system independent of extracellular calcium or phosphorus. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/18385669/Calcium_independent_and_125_OH_2D3_dependent_regulation_of_the_renin_angiotensin_system_in_1alpha_hydroxylase_knockout_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)53278-X DB - PRIME DP - Unbound Medicine ER -