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Recent advances in enantioselective [2 + 2 + 2] cycloaddition.
Org Biomol Chem. 2008 Apr 21; 6(8):1317-23.OB

Abstract

Enantioselective cycloaddition using chiral transition metal catalysts is an atom-economical and efficient synthetic tool for the construction of chiral carbo- and heterocyclic skeletons. This short account discloses our recent results of inter- and intramolecular enantioselective [2 + 2 + 2] cycloadditions of alkyne and/or alkene moiety(ies). Chiral iridium complexes catalyzed the alkyne trimerization for the generation of axial chirality(ies), and chiral rhodium ones catalyzed alkyne-alkyne-alkene cyclization for the generation of a quaternary carbon including spirocyclic system.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Shibata T
Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, 65-502B 3-4-1, Ohkubo, Shinjuku, Tokyo, 1698555, Japan.
Tsuchikama K
No affiliation info available

MeSH

AlkenesAlkynesCyclizationIridiumMolecular StructureOrganometallic CompoundsRhodiumStereoisomerism

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18385836

Citation

Shibata, Takanori, and Kyoji Tsuchikama. "Recent Advances in Enantioselective [2 + 2 + 2] Cycloaddition." Organic & Biomolecular Chemistry, vol. 6, no. 8, 2008, pp. 1317-23.
Shibata T, Tsuchikama K. Recent advances in enantioselective [2 + 2 + 2] cycloaddition. Org Biomol Chem. 2008;6(8):1317-23.
Shibata, T., & Tsuchikama, K. (2008). Recent advances in enantioselective [2 + 2 + 2] cycloaddition. Organic & Biomolecular Chemistry, 6(8), 1317-23. https://doi.org/10.1039/b720031e
Shibata T, Tsuchikama K. Recent Advances in Enantioselective [2 + 2 + 2] Cycloaddition. Org Biomol Chem. 2008 Apr 21;6(8):1317-23. PubMed PMID: 18385836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent advances in enantioselective [2 + 2 + 2] cycloaddition. AU - Shibata,Takanori, AU - Tsuchikama,Kyoji, Y1 - 2008/03/12/ PY - 2008/4/4/pubmed PY - 2008/7/4/medline PY - 2008/4/4/entrez SP - 1317 EP - 23 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 6 IS - 8 N2 - Enantioselective cycloaddition using chiral transition metal catalysts is an atom-economical and efficient synthetic tool for the construction of chiral carbo- and heterocyclic skeletons. This short account discloses our recent results of inter- and intramolecular enantioselective [2 + 2 + 2] cycloadditions of alkyne and/or alkene moiety(ies). Chiral iridium complexes catalyzed the alkyne trimerization for the generation of axial chirality(ies), and chiral rhodium ones catalyzed alkyne-alkyne-alkene cyclization for the generation of a quaternary carbon including spirocyclic system. SN - 1477-0520 UR - https://www.unboundmedicine.com/medline/citation/18385836/Recent_advances_in_enantioselective_[2_+_2_+_2]_cycloaddition_ DB - PRIME DP - Unbound Medicine ER -