Tags

Type your tag names separated by a space and hit enter

Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study.
Am J Med Genet A 2008; 146A(9):1128-33AJ

Abstract

Neural tube defects (NTDs) are severe congenital malformations due to failure of neural tube formation in early pregnancy. The proof that folic acid prevents NTDs raises the question of whether other parts of homocysteine (Hcy) metabolism may affect rates of NTDs. This French case-control study covered: 77 women aged 17-42 years sampled prior to elective abortion for a severe NTDs (cases) and 61 women aged 20-43 years with a normal pregnancy. Plasma and erythrocyte folate, plasma B6, B12 and Hcy were tested as five polymorphisms MTHFR 677 C --> T, MTHFR 1298 A --> C, MTR 2756 A --> G, MTTR 66 A --> G and TCN2 776 C --> G. Cases had significantly lower erythrocyte folate, plasma folate, B12 and B6 concentrations than the controls, and higher Hcy concentration. The odds ratio was 2.15 (95% CI: 1.00-4.59) for women with the MTRR 66 A --> G allele and it was decreased for mothers carrying the MTHFR 1298 A --> C allele. In multivariate analysis, only the erythrocyte folate concentration (P = 0.005) and plasma B6 concentration (P = 0.020) were predictors. Red cell folate is the main determinant of NTDs in France. Folic acid supplement or flour fortification would prevent most cases. Increased consumption of vitamins B12 and B6 could contribute to the prevention of NTDs. Genetic polymorphisms played only a small role. Until folic acid fortification becomes mandatory, all women of reproductive age should consume folic acid in a multivitamin that also contains B12 and B6.

Authors+Show Affiliations

Inserm U-145, Department of Biochemistry, CHU Nice Hôpital Pasteur, Nice, France. pantaleo.candito@wanadoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18386810

Citation

Candito, Mirande, et al. "Nutritional and Genetic Determinants of Vitamin B and Homocysteine Metabolisms in Neural Tube Defects: a Multicenter Case-control Study." American Journal of Medical Genetics. Part A, vol. 146A, no. 9, 2008, pp. 1128-33.
Candito M, Rivet R, Herbeth B, et al. Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study. Am J Med Genet A. 2008;146A(9):1128-33.
Candito, M., Rivet, R., Herbeth, B., Boisson, C., Rudigoz, R. C., Luton, D., ... Guéant, J. L. (2008). Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study. American Journal of Medical Genetics. Part A, 146A(9), pp. 1128-33. doi:10.1002/ajmg.a.32199.
Candito M, et al. Nutritional and Genetic Determinants of Vitamin B and Homocysteine Metabolisms in Neural Tube Defects: a Multicenter Case-control Study. Am J Med Genet A. 2008 May 1;146A(9):1128-33. PubMed PMID: 18386810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: a multicenter case-control study. AU - Candito,Mirande, AU - Rivet,Romain, AU - Herbeth,Bernard, AU - Boisson,Catherine, AU - Rudigoz,René-Charles, AU - Luton,Dominique, AU - Journel,Hubert, AU - Oury,Jean-François, AU - Roux,François, AU - Saura,Robert, AU - Vernhet,Isabelle, AU - Gaucherand,Pascal, AU - Muller,Françoise, AU - Guidicelli,Béatrice, AU - Heckenroth,Hélène, AU - Poulain,Patrice, AU - Blayau,Martine, AU - Francannet,Christine, AU - Roszyk,Laurence, AU - Brustié,Cécile, AU - Staccini,Pascal, AU - Gérard,Philippe, AU - Fillion-Emery,Nathalie, AU - Guéant-Rodriguez,Rosa-Maria, AU - Van Obberghen,Emmanuel, AU - Guéant,Jean-Louis, PY - 2008/4/5/pubmed PY - 2008/5/23/medline PY - 2008/4/5/entrez SP - 1128 EP - 33 JF - American journal of medical genetics. Part A JO - Am. J. Med. Genet. A VL - 146A IS - 9 N2 - Neural tube defects (NTDs) are severe congenital malformations due to failure of neural tube formation in early pregnancy. The proof that folic acid prevents NTDs raises the question of whether other parts of homocysteine (Hcy) metabolism may affect rates of NTDs. This French case-control study covered: 77 women aged 17-42 years sampled prior to elective abortion for a severe NTDs (cases) and 61 women aged 20-43 years with a normal pregnancy. Plasma and erythrocyte folate, plasma B6, B12 and Hcy were tested as five polymorphisms MTHFR 677 C --> T, MTHFR 1298 A --> C, MTR 2756 A --> G, MTTR 66 A --> G and TCN2 776 C --> G. Cases had significantly lower erythrocyte folate, plasma folate, B12 and B6 concentrations than the controls, and higher Hcy concentration. The odds ratio was 2.15 (95% CI: 1.00-4.59) for women with the MTRR 66 A --> G allele and it was decreased for mothers carrying the MTHFR 1298 A --> C allele. In multivariate analysis, only the erythrocyte folate concentration (P = 0.005) and plasma B6 concentration (P = 0.020) were predictors. Red cell folate is the main determinant of NTDs in France. Folic acid supplement or flour fortification would prevent most cases. Increased consumption of vitamins B12 and B6 could contribute to the prevention of NTDs. Genetic polymorphisms played only a small role. Until folic acid fortification becomes mandatory, all women of reproductive age should consume folic acid in a multivitamin that also contains B12 and B6. SN - 1552-4833 UR - https://www.unboundmedicine.com/medline/citation/18386810/Nutritional_and_genetic_determinants_of_vitamin_B_and_homocysteine_metabolisms_in_neural_tube_defects:_a_multicenter_case_control_study_ L2 - https://doi.org/10.1002/ajmg.a.32199 DB - PRIME DP - Unbound Medicine ER -