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Formulation of a cosurfactant-free O/W microemulsion using nonionic surfactant mixtures.
J Food Sci. 2008 Apr; 73(3):E115-21.JF

Abstract

A cosurfactant-free O/W microemulsion composed of oil, a mixture of hydrophilic and hydrophobic surfactants, and water has been developed using food-grade components as a nutrient delivery system. We started our investigation to monitor the phase behavior of this system based on a hydrophilic surfactant (Tween 80). From a phase diagram, the weight ratio of 5.4:33.8:60.8 = oil:surfactant:water was selected as a combination ratio for the O/W microemulsion system. We also investigated the combination effect of different hydrophobic surfactants to Tween 80 on microemulsion formation. Use of hydrophobic surfactants with Tween 80 produced smaller droplets than Tween 80 alone. Rheological studies showed that all microemulsions followed shear-thinning behavior. The turbidity of microemulsions did not change after accelerated stability tests, indicating that this microemulsion system was stable under the given harsh conditions. When docosahexaenoic acid (DHA) oil was applied to this microemulsion system, the particle size and the turbidity were not significantly changed. Dilution with a different aqueous medium, either water or acidic fluid, did not significantly change the microemulsion turbidity. DHA oil incorporated in microemulsion showed higher oxidation stability than free DHA oil.

Authors+Show Affiliations

Department of Biotechnology, Yonsei University, Seoul, 120-749, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18387105

Citation

Cho, Y-H, et al. "Formulation of a Cosurfactant-free O/W Microemulsion Using Nonionic Surfactant Mixtures." Journal of Food Science, vol. 73, no. 3, 2008, pp. E115-21.
Cho YH, Kim S, Bae EK, et al. Formulation of a cosurfactant-free O/W microemulsion using nonionic surfactant mixtures. J Food Sci. 2008;73(3):E115-21.
Cho, Y. H., Kim, S., Bae, E. K., Mok, C. K., & Park, J. (2008). Formulation of a cosurfactant-free O/W microemulsion using nonionic surfactant mixtures. Journal of Food Science, 73(3), E115-21. https://doi.org/10.1111/j.1750-3841.2008.00688.x
Cho YH, et al. Formulation of a Cosurfactant-free O/W Microemulsion Using Nonionic Surfactant Mixtures. J Food Sci. 2008;73(3):E115-21. PubMed PMID: 18387105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation of a cosurfactant-free O/W microemulsion using nonionic surfactant mixtures. AU - Cho,Y-H, AU - Kim,S, AU - Bae,E K, AU - Mok,C K, AU - Park,J, PY - 2008/4/5/pubmed PY - 2008/5/10/medline PY - 2008/4/5/entrez SP - E115 EP - 21 JF - Journal of food science JO - J Food Sci VL - 73 IS - 3 N2 - A cosurfactant-free O/W microemulsion composed of oil, a mixture of hydrophilic and hydrophobic surfactants, and water has been developed using food-grade components as a nutrient delivery system. We started our investigation to monitor the phase behavior of this system based on a hydrophilic surfactant (Tween 80). From a phase diagram, the weight ratio of 5.4:33.8:60.8 = oil:surfactant:water was selected as a combination ratio for the O/W microemulsion system. We also investigated the combination effect of different hydrophobic surfactants to Tween 80 on microemulsion formation. Use of hydrophobic surfactants with Tween 80 produced smaller droplets than Tween 80 alone. Rheological studies showed that all microemulsions followed shear-thinning behavior. The turbidity of microemulsions did not change after accelerated stability tests, indicating that this microemulsion system was stable under the given harsh conditions. When docosahexaenoic acid (DHA) oil was applied to this microemulsion system, the particle size and the turbidity were not significantly changed. Dilution with a different aqueous medium, either water or acidic fluid, did not significantly change the microemulsion turbidity. DHA oil incorporated in microemulsion showed higher oxidation stability than free DHA oil. SN - 1750-3841 UR - https://www.unboundmedicine.com/medline/citation/18387105/Formulation_of_a_cosurfactant_free_O/W_microemulsion_using_nonionic_surfactant_mixtures_ L2 - https://doi.org/10.1111/j.1750-3841.2008.00688.x DB - PRIME DP - Unbound Medicine ER -