Tags

Type your tag names separated by a space and hit enter

Reversibility of cardiac abnormalities in morbidly obese adolescents.
J Am Coll Cardiol. 2008 Apr 08; 51(14):1342-8.JACC

Abstract

OBJECTIVES

The purpose of this study was to evaluate changes in cardiac geometry, systolic and diastolic function before and after weight loss in morbidly obese adolescents.

BACKGROUND

Cardiac abnormalities are present in morbidly obese adolescents; however, it is unclear if they are reversible with weight loss.

METHODS

Data from 38 adolescents (13 to 19 years; 29 females, 9 males, 33 Caucasians, 5 African Americans) were evaluated before and after bariatric surgery. Left ventricular mass (LVM), left ventricular (LV) geometry, systolic and diastolic function were assessed by echocardiography. Mean follow up was 10 +/- 3 months.

RESULTS

Weight and body mass index decreased post-operatively (mean weight loss 59 +/- 15 kg, pre-operative body mass index 60 +/- 9 kg/m(2) vs. follow-up 40 +/- 8 kg/m(2), p < 0.0001). Change in LVM index (54 +/- 13 g/m(2.7) to 42 +/- 10 g/m(2.7), p < 0.0001) correlated with weight loss (r = 0.41, p = 0.01). Prevalence of concentric left ventricular hypertrophy (LVH) improved from 28% at pre-operative to only 3% at follow up (p = 0.007), and normal LV geometry improved from 36% to 79% at follow up (p = 0.009). Diastolic function also improved (mitral E/Ea lateral 7.7 +/- 2.3 at pre-operative vs. 6.3 +/- 1.6 at post-operative, p = 0.003). In addition, rate-pressure product improved suggesting decreased cardiac workload (p < 0.001).

CONCLUSIONS

Elevated LVM index, concentric LVH, altered diastolic function, and cardiac workload significantly improve following surgically induced weight loss in morbidly obese adolescents. Large weight loss due to bariatric surgery improves predictors of future cardiovascular morbidity in these young people.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Ippisch HM
Division of Cardiology, Cincinnati Children's Hospital, Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA. Holly.Ippisch@cchmc.org
Inge TH
No affiliation info available
Daniels SR
No affiliation info available
Wang B
No affiliation info available
Khoury PR
No affiliation info available
Witt SA
No affiliation info available
Glascock BJ
No affiliation info available
Garcia VF
No affiliation info available
Kimball TR
No affiliation info available

MeSH

AdolescentAdultBariatric SurgeryBody Mass IndexDiastoleDisease ProgressionFemaleHeartHeart DiseasesHumansHypertrophy, Left VentricularMaleObesity, MorbidPrevalenceSystoleWeight Loss

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18387434

Clinical Trial Links

Follow-up of Adolescent Bariatric Surgery

Citation

Ippisch, Holly M., et al. "Reversibility of Cardiac Abnormalities in Morbidly Obese Adolescents." Journal of the American College of Cardiology, vol. 51, no. 14, 2008, pp. 1342-8.
Ippisch HM, Inge TH, Daniels SR, et al. Reversibility of cardiac abnormalities in morbidly obese adolescents. J Am Coll Cardiol. 2008;51(14):1342-8.
Ippisch, H. M., Inge, T. H., Daniels, S. R., Wang, B., Khoury, P. R., Witt, S. A., Glascock, B. J., Garcia, V. F., & Kimball, T. R. (2008). Reversibility of cardiac abnormalities in morbidly obese adolescents. Journal of the American College of Cardiology, 51(14), 1342-8. https://doi.org/10.1016/j.jacc.2007.12.029
Ippisch HM, et al. Reversibility of Cardiac Abnormalities in Morbidly Obese Adolescents. J Am Coll Cardiol. 2008 Apr 8;51(14):1342-8. PubMed PMID: 18387434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reversibility of cardiac abnormalities in morbidly obese adolescents. AU - Ippisch,Holly M, AU - Inge,Thomas H, AU - Daniels,Stephen R, AU - Wang,Baiyang, AU - Khoury,Philip R, AU - Witt,Sandra A, AU - Glascock,Betty J, AU - Garcia,Victor F, AU - Kimball,Thomas R, PY - 2007/05/24/received PY - 2007/12/17/revised PY - 2007/12/18/accepted PY - 2008/4/5/pubmed PY - 2008/5/3/medline PY - 2008/4/5/entrez SP - 1342 EP - 8 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 51 IS - 14 N2 - OBJECTIVES: The purpose of this study was to evaluate changes in cardiac geometry, systolic and diastolic function before and after weight loss in morbidly obese adolescents. BACKGROUND: Cardiac abnormalities are present in morbidly obese adolescents; however, it is unclear if they are reversible with weight loss. METHODS: Data from 38 adolescents (13 to 19 years; 29 females, 9 males, 33 Caucasians, 5 African Americans) were evaluated before and after bariatric surgery. Left ventricular mass (LVM), left ventricular (LV) geometry, systolic and diastolic function were assessed by echocardiography. Mean follow up was 10 +/- 3 months. RESULTS: Weight and body mass index decreased post-operatively (mean weight loss 59 +/- 15 kg, pre-operative body mass index 60 +/- 9 kg/m(2) vs. follow-up 40 +/- 8 kg/m(2), p < 0.0001). Change in LVM index (54 +/- 13 g/m(2.7) to 42 +/- 10 g/m(2.7), p < 0.0001) correlated with weight loss (r = 0.41, p = 0.01). Prevalence of concentric left ventricular hypertrophy (LVH) improved from 28% at pre-operative to only 3% at follow up (p = 0.007), and normal LV geometry improved from 36% to 79% at follow up (p = 0.009). Diastolic function also improved (mitral E/Ea lateral 7.7 +/- 2.3 at pre-operative vs. 6.3 +/- 1.6 at post-operative, p = 0.003). In addition, rate-pressure product improved suggesting decreased cardiac workload (p < 0.001). CONCLUSIONS: Elevated LVM index, concentric LVH, altered diastolic function, and cardiac workload significantly improve following surgically induced weight loss in morbidly obese adolescents. Large weight loss due to bariatric surgery improves predictors of future cardiovascular morbidity in these young people. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/18387434/Reversibility_of_cardiac_abnormalities_in_morbidly_obese_adolescents_ DB - PRIME DP - Unbound Medicine ER -