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    Effects of policosanol (10 mg/d) versus aspirin (100 mg/d) in patients with intermittent claudication: a 10-week, randomized, comparative study.

    Abstract

    Antiplatelet therapy, including aspirin, is recommended to lower the vascular risk in patients with intermittent claudication. Policosanol has increased walking distances in these patients, probably because of its antiplatelet effects, but the effect of shorter treatment has not been studied. This double-blind study compared the effects of policosanol 10 mg/d and aspirin 100 mg/d for 10 weeks on walking distances in claudicants. Thirty-nine patients were randomized to policosanol or aspirin. Walking distances on a treadmill were assessed before and after treatment. Policosanol significantly increased the initial and absolute claudication distances, while aspirin changed neither variable. Policosanol, not aspirin, significantly lowered serum low-density lipoprotein-cholesterol and total cholesterol while raising high-density lipoprotein-cholesterol. In conclusion, treatments of policosanol, not aspirin, for 10 weeks significantly increased walking distances, but modestly, in contrast with previous results. Therefore, the duration of treatments at the doses tested was too short for meaningful effects on the treadmill test.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Illnait J
    ,

    Medical Surgical Research Centre, Havana City, Cuba. clinica@enet.cu

    Castaño G
    ,
    Alvarez E
    ,
    Fernández L
    ,
    Mas R
    ,
    Mendoza S
    ,
    Gamez R

    Source

    Angiology 59:3 pg 269-77

    MeSH

    Adult
    Aged
    Aspirin
    Double-Blind Method
    Drug Administration Schedule
    Exercise Test
    Fatty Alcohols
    Female
    Humans
    Intermittent Claudication
    Lipids
    Male
    Middle Aged
    Platelet Aggregation Inhibitors
    Recovery of Function
    Treatment Outcome
    Walking

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18388038

    Citation

    TY - JOUR T1 - Effects of policosanol (10 mg/d) versus aspirin (100 mg/d) in patients with intermittent claudication: a 10-week, randomized, comparative study. AU - Illnait,José, AU - Castaño,Gladys, AU - Alvarez,Ernesto, AU - Fernández,Lilia, AU - Mas,Rosa, AU - Mendoza,Sarahí, AU - Gamez,Rafael, Y1 - 2008/04/02/ PY - 2008/4/2/aheadofprint PY - 2008/4/5/pubmed PY - 2008/7/4/medline PY - 2008/4/5/entrez SP - 269 EP - 77 JF - Angiology JO - Angiology VL - 59 IS - 3 N2 - Antiplatelet therapy, including aspirin, is recommended to lower the vascular risk in patients with intermittent claudication. Policosanol has increased walking distances in these patients, probably because of its antiplatelet effects, but the effect of shorter treatment has not been studied. This double-blind study compared the effects of policosanol 10 mg/d and aspirin 100 mg/d for 10 weeks on walking distances in claudicants. Thirty-nine patients were randomized to policosanol or aspirin. Walking distances on a treadmill were assessed before and after treatment. Policosanol significantly increased the initial and absolute claudication distances, while aspirin changed neither variable. Policosanol, not aspirin, significantly lowered serum low-density lipoprotein-cholesterol and total cholesterol while raising high-density lipoprotein-cholesterol. In conclusion, treatments of policosanol, not aspirin, for 10 weeks significantly increased walking distances, but modestly, in contrast with previous results. Therefore, the duration of treatments at the doses tested was too short for meaningful effects on the treadmill test. SN - 1940-1574 UR - https://www.unboundmedicine.com/medline/citation/18388038/full_citation/Effects_of_Policosanol__10_mg/d__Versus_Aspirin__100_mg/d__in_Patients_With_Intermittent_Claudication:_A_10_week_Randomized_Comparative_Study_ L2 - http://ang.sagepub.com/cgi/pmidlookup?view=long&pmid=18388038 ER -