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Antimicrobial activity of various parts of Polyalthia longifolia var. pendula: isolation of active principles from the leaves and the berries.
Phytother Res. 2008 Jul; 22(7):907-12.PR

Abstract

Methanol extracts of leaves, stem, twigs, green berries, flowers, roots, root-wood and root-bark of Polyalthia longifolia var. pendula, were tested for their antibacterial and antifungal potentials. Bioassay monitored isolation work on the methanol extract of leaves and berries which possess promising antibacterial activity led to the isolation of seven clerodane diterpenoids, 16(R and S)-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide (1), 16-oxo-cleroda-3,13(14)E-dien-15-oic acid (2), methyl-16-oxo-cleroda-3,13(14)E-dien-15-oate (3), 2-oxo-kolavenic acid (4), 16 (R and S)-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide-2-one (5), (4-->2)-abeo-16(R and S)-hydroxy-cleroda-2,13(14)Z-dien-15,16-olide-3-al (6), 3beta,16alpha-dihydroxy-cleroda-4(18), 13(14)Z-dien-15,16-olide (7), while kolavenic acid (8) and solidagonal acid (9) were obtained from the root-wood. Diterpenoids 1 and 8 were also obtained from the root-bark. It is the first report of the isolation of 7 and 9 from this source, and clerodane 3 was obtained as a natural product for the first time. Clerodanes 1, 2, 5, 6 and 7 were found to be active antimicrobial agents with MIC values ranging between 7.8 and 500 microg/mL. Diterpenoid 1 emerged as the most active antimicrobial agent. The acetyl derivative (10) of 1 and the methyl derivative (3) of 2 were found to be less active than the parent compounds. A complex of allantoin was also obtained from the berries, which on hydrolysis furnished pure allantoin (11).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Faizi S
International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. shaheenfaizi@hotmail.com
Khan RA
No affiliation info available
Mughal NR
No affiliation info available
Malik MS
No affiliation info available
Sajjadi KE
No affiliation info available
Ahmad A
No affiliation info available

MeSH

Anti-Infective AgentsDiterpenesDose-Response Relationship, DrugFruitFungiGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsPlant ExtractsPlant LeavesPolyalthia

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18389472

Citation

Faizi, Shaheen, et al. "Antimicrobial Activity of Various Parts of Polyalthia Longifolia Var. Pendula: Isolation of Active Principles From the Leaves and the Berries." Phytotherapy Research : PTR, vol. 22, no. 7, 2008, pp. 907-12.
Faizi S, Khan RA, Mughal NR, et al. Antimicrobial activity of various parts of Polyalthia longifolia var. pendula: isolation of active principles from the leaves and the berries. Phytother Res. 2008;22(7):907-12.
Faizi, S., Khan, R. A., Mughal, N. R., Malik, M. S., Sajjadi, K. E., & Ahmad, A. (2008). Antimicrobial activity of various parts of Polyalthia longifolia var. pendula: isolation of active principles from the leaves and the berries. Phytotherapy Research : PTR, 22(7), 907-12. https://doi.org/10.1002/ptr.2414
Faizi S, et al. Antimicrobial Activity of Various Parts of Polyalthia Longifolia Var. Pendula: Isolation of Active Principles From the Leaves and the Berries. Phytother Res. 2008;22(7):907-12. PubMed PMID: 18389472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial activity of various parts of Polyalthia longifolia var. pendula: isolation of active principles from the leaves and the berries. AU - Faizi,Shaheen, AU - Khan,Rashid Ali, AU - Mughal,Najma Rasool, AU - Malik,Mariam Shafique, AU - Sajjadi,Kaneez-E-Sayyeda, AU - Ahmad,Aqeel, PY - 2008/4/5/pubmed PY - 2008/8/8/medline PY - 2008/4/5/entrez SP - 907 EP - 12 JF - Phytotherapy research : PTR JO - Phytother Res VL - 22 IS - 7 N2 - Methanol extracts of leaves, stem, twigs, green berries, flowers, roots, root-wood and root-bark of Polyalthia longifolia var. pendula, were tested for their antibacterial and antifungal potentials. Bioassay monitored isolation work on the methanol extract of leaves and berries which possess promising antibacterial activity led to the isolation of seven clerodane diterpenoids, 16(R and S)-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide (1), 16-oxo-cleroda-3,13(14)E-dien-15-oic acid (2), methyl-16-oxo-cleroda-3,13(14)E-dien-15-oate (3), 2-oxo-kolavenic acid (4), 16 (R and S)-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide-2-one (5), (4-->2)-abeo-16(R and S)-hydroxy-cleroda-2,13(14)Z-dien-15,16-olide-3-al (6), 3beta,16alpha-dihydroxy-cleroda-4(18), 13(14)Z-dien-15,16-olide (7), while kolavenic acid (8) and solidagonal acid (9) were obtained from the root-wood. Diterpenoids 1 and 8 were also obtained from the root-bark. It is the first report of the isolation of 7 and 9 from this source, and clerodane 3 was obtained as a natural product for the first time. Clerodanes 1, 2, 5, 6 and 7 were found to be active antimicrobial agents with MIC values ranging between 7.8 and 500 microg/mL. Diterpenoid 1 emerged as the most active antimicrobial agent. The acetyl derivative (10) of 1 and the methyl derivative (3) of 2 were found to be less active than the parent compounds. A complex of allantoin was also obtained from the berries, which on hydrolysis furnished pure allantoin (11). SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/18389472/Antimicrobial_activity_of_various_parts_of_Polyalthia_longifolia_var__pendula:_isolation_of_active_principles_from_the_leaves_and_the_berries_ DB - PRIME DP - Unbound Medicine ER -