Tags

Type your tag names separated by a space and hit enter

Extended spectrum Beta-Lactamase-producing Klebsiella pneumoniae septicaemia outbreak in the Neonatal Intensive Care Unit of a tertiary hospital in Nigeria.
Afr J Med Med Sci. 2007 Sep; 36(3):225-8.AJ

Abstract

Between March and August 2002 a cluster of nosocomial septicaemia associated with Extended Spectrum beta lactamase (ESBL)-producing Klebsiella pneumoniae was observed in 11 neonates from the neonatal intensive care unit of a 200-bed tertiary hospital in Abuja, the Federal Capital territory of Nigeria. An investigation was conducted to identify the possible reservoirs and mode of transmission. Infection control measures and epidemiologic surveillance were executed. The environment was investigated by collecting and processing several swab samples for microbiological studies. Antibiogram tests and extended spectrum beta lactamase production test were performed on all K. pneumoniae isolates from both the environment and the patients, and all bacteraemic and environmental isolates of K. pneumoniae compared. A total of 30 K. pneumoniae isolates made up of 17 from the patients and 13 from the environment were analysed. An identical antibiogram was found in 24 isolates, which included all the 17 from the patients and the 7 from the hands of staff, sink and incubator surface in the NICU. Mortality rate from the outbreak was 36.4% and constituted 10.8% of all deaths in the unit in 2002. Overall mortality in the unit for 2002 was 28.9%. The outbreak significantly caused more deaths than usual in the unit. The nosocomial septicaemia was caused by a single ESBL-producing strain of K. pneumnoniae brought into the hospital by a neonate delivered and admitted from an external health institution. Sink and the incubator were also contaminated by the same strain.

Authors+Show Affiliations

Department of Medical Microbiology and Parasitology, National Hospital, Abuja, Nigeria. keniregbu@yahoo.co.ukNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18390061

Citation

Iregbu, K C., and U Anwaal. "Extended Spectrum Beta-Lactamase-producing Klebsiella Pneumoniae Septicaemia Outbreak in the Neonatal Intensive Care Unit of a Tertiary Hospital in Nigeria." African Journal of Medicine and Medical Sciences, vol. 36, no. 3, 2007, pp. 225-8.
Iregbu KC, Anwaal U. Extended spectrum Beta-Lactamase-producing Klebsiella pneumoniae septicaemia outbreak in the Neonatal Intensive Care Unit of a tertiary hospital in Nigeria. Afr J Med Med Sci. 2007;36(3):225-8.
Iregbu, K. C., & Anwaal, U. (2007). Extended spectrum Beta-Lactamase-producing Klebsiella pneumoniae septicaemia outbreak in the Neonatal Intensive Care Unit of a tertiary hospital in Nigeria. African Journal of Medicine and Medical Sciences, 36(3), 225-8.
Iregbu KC, Anwaal U. Extended Spectrum Beta-Lactamase-producing Klebsiella Pneumoniae Septicaemia Outbreak in the Neonatal Intensive Care Unit of a Tertiary Hospital in Nigeria. Afr J Med Med Sci. 2007;36(3):225-8. PubMed PMID: 18390061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extended spectrum Beta-Lactamase-producing Klebsiella pneumoniae septicaemia outbreak in the Neonatal Intensive Care Unit of a tertiary hospital in Nigeria. AU - Iregbu,K C, AU - Anwaal,U, PY - 2008/4/9/pubmed PY - 2008/6/5/medline PY - 2008/4/9/entrez SP - 225 EP - 8 JF - African journal of medicine and medical sciences JO - Afr J Med Med Sci VL - 36 IS - 3 N2 - Between March and August 2002 a cluster of nosocomial septicaemia associated with Extended Spectrum beta lactamase (ESBL)-producing Klebsiella pneumoniae was observed in 11 neonates from the neonatal intensive care unit of a 200-bed tertiary hospital in Abuja, the Federal Capital territory of Nigeria. An investigation was conducted to identify the possible reservoirs and mode of transmission. Infection control measures and epidemiologic surveillance were executed. The environment was investigated by collecting and processing several swab samples for microbiological studies. Antibiogram tests and extended spectrum beta lactamase production test were performed on all K. pneumoniae isolates from both the environment and the patients, and all bacteraemic and environmental isolates of K. pneumoniae compared. A total of 30 K. pneumoniae isolates made up of 17 from the patients and 13 from the environment were analysed. An identical antibiogram was found in 24 isolates, which included all the 17 from the patients and the 7 from the hands of staff, sink and incubator surface in the NICU. Mortality rate from the outbreak was 36.4% and constituted 10.8% of all deaths in the unit in 2002. Overall mortality in the unit for 2002 was 28.9%. The outbreak significantly caused more deaths than usual in the unit. The nosocomial septicaemia was caused by a single ESBL-producing strain of K. pneumnoniae brought into the hospital by a neonate delivered and admitted from an external health institution. Sink and the incubator were also contaminated by the same strain. SN - 0309-3913 UR - https://www.unboundmedicine.com/medline/citation/18390061/Extended_spectrum_Beta_Lactamase_producing_Klebsiella_pneumoniae_septicaemia_outbreak_in_the_Neonatal_Intensive_Care_Unit_of_a_tertiary_hospital_in_Nigeria_ L2 - http://www.diseaseinfosearch.org/result/4006 DB - PRIME DP - Unbound Medicine ER -