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[Positive tests for serum anti-endomysium antibodies (AEA) and anti-jejunal antibodies (JAB) and histopathological diagnosis of celiac disease in children].
Vnitr Lek 2008; 54(1):25-30VL

Abstract

Non-invasive examination methods are increasingly important in diagnosing celiac disease. New options for diagnosing celiac disease have been discovered in addition to the established biochemical, hematological and other methods as a result expansive progress ofclinical genetics and immunology. At the same time, detection of circulating auto-antibodies is becoming ever more frequent in clinical practice. As a result, many new, clinically highly heterogeneous cases of the disease have been diagnosed and consequently the prevalence of the disease in both child and adult population has grown. Detection of anti-endomysial antibodies (AEA), characteristic for their high sensitivity and specificity, plays an important role in diagnosing and monitoring celiac disease in pediatric practice. Nevertheless, histopathological diagnosis remains the critical tool for definitive diagnosis of the disease. The article refers to relations between the degree of positivity of AEA and JAB antibodies in the IgA class and the respective grade in the Marsh grading system. The objective of the study was to examine AEA and JAB antibodies and the histological picture of the duodenal mucosa in 20 children and adolescents with celiac disease aged from 2 to 18 years. The authors developed a semiquantitative scale of positivity of both the antibodies, which they compared trying to find a correlation between these and the histopathological picture of the duodenal mucosa. The authors point out the need of timely determination of AEA and t-TG (tissue transglutaminase) in patients whose anamnesis, clinical picture or laboratory results may be indicative of celiac disease.

Authors+Show Affiliations

Ustav patológie FN Nitra, Slovenská republika. pmakovicky@email.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

slo

PubMed ID

18390114

Citation

Makovický, P E., et al. "[Positive Tests for Serum Anti-endomysium Antibodies (AEA) and Anti-jejunal Antibodies (JAB) and Histopathological Diagnosis of Celiac Disease in Children]." Vnitrni Lekarstvi, vol. 54, no. 1, 2008, pp. 25-30.
Makovický PE, Makovický PA, Klimik M, et al. [Positive tests for serum anti-endomysium antibodies (AEA) and anti-jejunal antibodies (JAB) and histopathological diagnosis of celiac disease in children]. Vnitr Lek. 2008;54(1):25-30.
Makovický, P. E., Makovický, P. A., Klimik, M., Gregus, M., & Zimmermann, M. (2008). [Positive tests for serum anti-endomysium antibodies (AEA) and anti-jejunal antibodies (JAB) and histopathological diagnosis of celiac disease in children]. Vnitrni Lekarstvi, 54(1), pp. 25-30.
Makovický PE, et al. [Positive Tests for Serum Anti-endomysium Antibodies (AEA) and Anti-jejunal Antibodies (JAB) and Histopathological Diagnosis of Celiac Disease in Children]. Vnitr Lek. 2008;54(1):25-30. PubMed PMID: 18390114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Positive tests for serum anti-endomysium antibodies (AEA) and anti-jejunal antibodies (JAB) and histopathological diagnosis of celiac disease in children]. AU - Makovický,P E, AU - Makovický,P A, AU - Klimik,M, AU - Gregus,M, AU - Zimmermann,M, PY - 2008/4/9/pubmed PY - 2008/5/21/medline PY - 2008/4/9/entrez SP - 25 EP - 30 JF - Vnitrni lekarstvi JO - Vnitr Lek VL - 54 IS - 1 N2 - Non-invasive examination methods are increasingly important in diagnosing celiac disease. New options for diagnosing celiac disease have been discovered in addition to the established biochemical, hematological and other methods as a result expansive progress ofclinical genetics and immunology. At the same time, detection of circulating auto-antibodies is becoming ever more frequent in clinical practice. As a result, many new, clinically highly heterogeneous cases of the disease have been diagnosed and consequently the prevalence of the disease in both child and adult population has grown. Detection of anti-endomysial antibodies (AEA), characteristic for their high sensitivity and specificity, plays an important role in diagnosing and monitoring celiac disease in pediatric practice. Nevertheless, histopathological diagnosis remains the critical tool for definitive diagnosis of the disease. The article refers to relations between the degree of positivity of AEA and JAB antibodies in the IgA class and the respective grade in the Marsh grading system. The objective of the study was to examine AEA and JAB antibodies and the histological picture of the duodenal mucosa in 20 children and adolescents with celiac disease aged from 2 to 18 years. The authors developed a semiquantitative scale of positivity of both the antibodies, which they compared trying to find a correlation between these and the histopathological picture of the duodenal mucosa. The authors point out the need of timely determination of AEA and t-TG (tissue transglutaminase) in patients whose anamnesis, clinical picture or laboratory results may be indicative of celiac disease. SN - 0042-773X UR - https://www.unboundmedicine.com/medline/citation/18390114/[Positive_tests_for_serum_anti_endomysium_antibodies__AEA__and_anti_jejunal_antibodies__JAB__and_histopathological_diagnosis_of_celiac_disease_in_children]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -