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The role of selenium in chronic disease.
Nutr Clin Pract 2008 Apr-May; 23(2):152-60NC

Abstract

Selenium functions as a part of proteins known as selenoproteins. Through these selenoproteins, selenium functions as a defensive mechanism for oxidative stress, for the regulation of thyroid hormone activity, and for the redox status of vitamin C and other molecules. In several of its roles, selenium functions as a dietary antioxidant and thus has been studied for its possible role in chronic diseases. This article reviews recent studies regarding selenium status or supplementation in hypertension, cardiovascular disease, cancer, and diabetes mellitus. A few studies regarding aging and mortality are also included. What can be ascertained from this current review is that the maintenance of adequate selenium nutriture and, at minimum, the prevention of a deficiency in selenium would be advisable for all individuals. In addition, the indiscriminant use of selenium supplements should be approached with caution until further randomized, controlled trials monitor the effects of such supplementation, especially on a long-term basis.

Authors+Show Affiliations

Division of Clinical Nutrition, University of Kentucky, College of Health Sciences, Lexington, KY 40536-0200, USA. mgboos01@uky.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18390782

Citation

Boosalis, Maria G.. "The Role of Selenium in Chronic Disease." Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, vol. 23, no. 2, 2008, pp. 152-60.
Boosalis MG. The role of selenium in chronic disease. Nutr Clin Pract. 2008;23(2):152-60.
Boosalis, M. G. (2008). The role of selenium in chronic disease. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 23(2), pp. 152-60. doi:10.1177/0884533608314532.
Boosalis MG. The Role of Selenium in Chronic Disease. Nutr Clin Pract. 2008;23(2):152-60. PubMed PMID: 18390782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of selenium in chronic disease. A1 - Boosalis,Maria G, PY - 2008/4/9/pubmed PY - 2008/8/12/medline PY - 2008/4/9/entrez SP - 152 EP - 60 JF - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JO - Nutr Clin Pract VL - 23 IS - 2 N2 - Selenium functions as a part of proteins known as selenoproteins. Through these selenoproteins, selenium functions as a defensive mechanism for oxidative stress, for the regulation of thyroid hormone activity, and for the redox status of vitamin C and other molecules. In several of its roles, selenium functions as a dietary antioxidant and thus has been studied for its possible role in chronic diseases. This article reviews recent studies regarding selenium status or supplementation in hypertension, cardiovascular disease, cancer, and diabetes mellitus. A few studies regarding aging and mortality are also included. What can be ascertained from this current review is that the maintenance of adequate selenium nutriture and, at minimum, the prevention of a deficiency in selenium would be advisable for all individuals. In addition, the indiscriminant use of selenium supplements should be approached with caution until further randomized, controlled trials monitor the effects of such supplementation, especially on a long-term basis. SN - 0884-5336 UR - https://www.unboundmedicine.com/medline/citation/18390782/The_role_of_selenium_in_chronic_disease_ L2 - https://doi.org/10.1177/0884533608314532 DB - PRIME DP - Unbound Medicine ER -