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Menopausal complaints are associated with cardiovascular risk factors.
Hypertension 2008; 51(6):1492-8H

Abstract

It has been hypothesized that women with vasomotor symptoms differ from those without with respect to cardiovascular risk factors or responses to exogenous hormone therapy. We studied whether the presence and extent of menopausal complaints are associated with cardiovascular risk profile. Data were used from a population-based sample of 5523 women, aged 46 to 57 years, enrolled between 1994 and 1995. Data on menopausal complaints and potential confounders were collected by questionnaires. Total cholesterol, systolic and diastolic blood pressures, and body mass index were measured. Linear and logistic regression analyses were used to analyze the data. Night sweats were reported by 38% and flushing by 39% of women. After multivariate adjustment, women with complaints of flushing had a 0.27-mmol/L (95% CI: 0.15 to 0.39) higher cholesterol level, a 0.60-kg/m(2) (95% CI: 0.35 to 0.84) higher BMI, a 1.59-mm Hg (95% CI: 0.52 to 2.67) higher systolic blood pressure, and a 1.09-mm Hg (95% CI: 0.48 to 1.69) higher diastolic blood pressure compared with asymptomatic women. Flushing was also associated with hypercholesterolemia (odds ratio: 1.52; 95% CI: 1.25 to 1.84) and hypertension (OR: 1.20; 95% CI: 1.07 to 1.34). Results were similar for complaints of night sweating. The findings support the view that menopausal complaints are associated with a less favorable cardiovascular risk profile. These findings substantiate the view that differences in the presence of menopausal symptoms as a reason for using hormone therapy could explain discrepant findings between observational research and trials.

Authors+Show Affiliations

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room STR 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands. G.C.M.Gast@umcutrecht.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18391100

Citation

Gast, Gerrie-Cor M., et al. "Menopausal Complaints Are Associated With Cardiovascular Risk Factors." Hypertension (Dallas, Tex. : 1979), vol. 51, no. 6, 2008, pp. 1492-8.
Gast GC, Grobbee DE, Pop VJ, et al. Menopausal complaints are associated with cardiovascular risk factors. Hypertension. 2008;51(6):1492-8.
Gast, G. C., Grobbee, D. E., Pop, V. J., Keyzer, J. J., Wijnands-van Gent, C. J., Samsioe, G. N., ... van der Schouw, Y. T. (2008). Menopausal complaints are associated with cardiovascular risk factors. Hypertension (Dallas, Tex. : 1979), 51(6), pp. 1492-8. doi:10.1161/HYPERTENSIONAHA.107.106526.
Gast GC, et al. Menopausal Complaints Are Associated With Cardiovascular Risk Factors. Hypertension. 2008;51(6):1492-8. PubMed PMID: 18391100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Menopausal complaints are associated with cardiovascular risk factors. AU - Gast,Gerrie-Cor M, AU - Grobbee,Diederick E, AU - Pop,Victor J M, AU - Keyzer,Jules J, AU - Wijnands-van Gent,Colette J M, AU - Samsioe,Göran N, AU - Nilsson,Peter M, AU - van der Schouw,Yvonne T, Y1 - 2008/04/07/ PY - 2008/4/9/pubmed PY - 2008/7/1/medline PY - 2008/4/9/entrez SP - 1492 EP - 8 JF - Hypertension (Dallas, Tex. : 1979) JO - Hypertension VL - 51 IS - 6 N2 - It has been hypothesized that women with vasomotor symptoms differ from those without with respect to cardiovascular risk factors or responses to exogenous hormone therapy. We studied whether the presence and extent of menopausal complaints are associated with cardiovascular risk profile. Data were used from a population-based sample of 5523 women, aged 46 to 57 years, enrolled between 1994 and 1995. Data on menopausal complaints and potential confounders were collected by questionnaires. Total cholesterol, systolic and diastolic blood pressures, and body mass index were measured. Linear and logistic regression analyses were used to analyze the data. Night sweats were reported by 38% and flushing by 39% of women. After multivariate adjustment, women with complaints of flushing had a 0.27-mmol/L (95% CI: 0.15 to 0.39) higher cholesterol level, a 0.60-kg/m(2) (95% CI: 0.35 to 0.84) higher BMI, a 1.59-mm Hg (95% CI: 0.52 to 2.67) higher systolic blood pressure, and a 1.09-mm Hg (95% CI: 0.48 to 1.69) higher diastolic blood pressure compared with asymptomatic women. Flushing was also associated with hypercholesterolemia (odds ratio: 1.52; 95% CI: 1.25 to 1.84) and hypertension (OR: 1.20; 95% CI: 1.07 to 1.34). Results were similar for complaints of night sweating. The findings support the view that menopausal complaints are associated with a less favorable cardiovascular risk profile. These findings substantiate the view that differences in the presence of menopausal symptoms as a reason for using hormone therapy could explain discrepant findings between observational research and trials. SN - 1524-4563 UR - https://www.unboundmedicine.com/medline/citation/18391100/Menopausal_complaints_are_associated_with_cardiovascular_risk_factors_ L2 - http://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.107.106526?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -