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Pediatric nonalcoholic fatty liver disease.
Gastroenterol Nurs. 2008 Mar-Apr; 31(2):115-9.GN

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease related to excessive accumulation of hepatic fat, and represents a spectrum of liver disease ranging from fat accumulation alone (steatosis) to the more significant histologic finding of steatohepatitis. Nonalcoholic steatohepatitis is a progressive liver disease associated with increased risk of liver cirrhosis and cancer. NAFLD is becoming increasingly prevalent in the pediatric population in direct correlation with the emergence of childhood obesity as a significant pediatric health problem. The exact pathophysiology of NAFLD remains unclear, although the interplay of insulin resistance, oxidative stress, and release of proinflammatory cytokines are implicated in the process. The diagnostic workup and treatment for NAFLD and nonalcoholic steatohepatitis remains controversial. This review discusses current concepts regarding the natural history, pathophysiology, and management of pediatric patients with NAFLD.

Authors+Show Affiliations

Division of Pediatric Gastroenterology and Nutrition, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA. slerret@mcw.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18391799

Citation

Lerret, Stacee M., and Joseph A. Skelton. "Pediatric Nonalcoholic Fatty Liver Disease." Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates, vol. 31, no. 2, 2008, pp. 115-9.
Lerret SM, Skelton JA. Pediatric nonalcoholic fatty liver disease. Gastroenterol Nurs. 2008;31(2):115-9.
Lerret, S. M., & Skelton, J. A. (2008). Pediatric nonalcoholic fatty liver disease. Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates, 31(2), 115-9. https://doi.org/10.1097/01.SGA.0000316530.31366.6e
Lerret SM, Skelton JA. Pediatric Nonalcoholic Fatty Liver Disease. Gastroenterol Nurs. 2008;31(2):115-9. PubMed PMID: 18391799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pediatric nonalcoholic fatty liver disease. AU - Lerret,Stacee M, AU - Skelton,Joseph A, PY - 2008/4/9/pubmed PY - 2008/6/27/medline PY - 2008/4/9/entrez SP - 115 EP - 9 JF - Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates JO - Gastroenterol Nurs VL - 31 IS - 2 N2 - Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease related to excessive accumulation of hepatic fat, and represents a spectrum of liver disease ranging from fat accumulation alone (steatosis) to the more significant histologic finding of steatohepatitis. Nonalcoholic steatohepatitis is a progressive liver disease associated with increased risk of liver cirrhosis and cancer. NAFLD is becoming increasingly prevalent in the pediatric population in direct correlation with the emergence of childhood obesity as a significant pediatric health problem. The exact pathophysiology of NAFLD remains unclear, although the interplay of insulin resistance, oxidative stress, and release of proinflammatory cytokines are implicated in the process. The diagnostic workup and treatment for NAFLD and nonalcoholic steatohepatitis remains controversial. This review discusses current concepts regarding the natural history, pathophysiology, and management of pediatric patients with NAFLD. SN - 1042-895X UR - https://www.unboundmedicine.com/medline/citation/18391799/Pediatric_nonalcoholic_fatty_liver_disease_ L2 - http://dx.doi.org/10.1097/01.SGA.0000316530.31366.6e DB - PRIME DP - Unbound Medicine ER -