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Capillary electrophoresis for pharmaceutical analysis.
Methods Mol Biol. 2008; 384:205-45.MM

Abstract

This chapter describes the application of capillary electrophoresis (CE) to pharmaceutical analysis. The areas of pharmaceutical analysis covered are enantiomer separation, analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, related substances determinations, and physiochemical measurements such as log P and pKa of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details. Information on electrolyte choice and method optimization to obtain optimal separations is included.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Marsh A
GlaxoSmithKline Research & Development, Harlow, Essex, UK.
Broderick M
No affiliation info available
Altria K
No affiliation info available
Power J
No affiliation info available
Donegan S
No affiliation info available
Clark B
No affiliation info available

MeSH

Anti-Bacterial AgentsCarbohydratesChromatography, Micellar Electrokinetic CapillaryCrown EthersCyclodextrinsElectrophoresis, CapillaryHydrogen-Ion ConcentrationPharmaceutical PreparationsProteinsReproducibility of ResultsStereoisomerism

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18392572

Citation

Marsh, Alex, et al. "Capillary Electrophoresis for Pharmaceutical Analysis." Methods in Molecular Biology (Clifton, N.J.), vol. 384, 2008, pp. 205-45.
Marsh A, Broderick M, Altria K, et al. Capillary electrophoresis for pharmaceutical analysis. Methods Mol Biol. 2008;384:205-45.
Marsh, A., Broderick, M., Altria, K., Power, J., Donegan, S., & Clark, B. (2008). Capillary electrophoresis for pharmaceutical analysis. Methods in Molecular Biology (Clifton, N.J.), 384, 205-45. https://doi.org/10.1007/978-1-59745-376-9_10
Marsh A, et al. Capillary Electrophoresis for Pharmaceutical Analysis. Methods Mol Biol. 2008;384:205-45. PubMed PMID: 18392572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Capillary electrophoresis for pharmaceutical analysis. AU - Marsh,Alex, AU - Broderick,Margo, AU - Altria,Kevin, AU - Power,Joe, AU - Donegan,Sheila, AU - Clark,Brian, PY - 2008/4/9/pubmed PY - 2008/5/8/medline PY - 2008/4/9/entrez SP - 205 EP - 45 JF - Methods in molecular biology (Clifton, N.J.) JO - Methods Mol Biol VL - 384 N2 - This chapter describes the application of capillary electrophoresis (CE) to pharmaceutical analysis. The areas of pharmaceutical analysis covered are enantiomer separation, analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, related substances determinations, and physiochemical measurements such as log P and pKa of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details. Information on electrolyte choice and method optimization to obtain optimal separations is included. SN - 1064-3745 UR - https://www.unboundmedicine.com/medline/citation/18392572/Capillary_electrophoresis_for_pharmaceutical_analysis_ DB - PRIME DP - Unbound Medicine ER -