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Cancer chemoprevention by garlic and its organosulfur compounds-panacea or promise?
Anticancer Agents Med Chem 2008; 8(3):313-21AA

Abstract

Of late medicinal plants and functional foods rich in bioactive phytochemicals have received growing attention as potential agents for cancer chemoprevention. Accumulating evidence from epidemiological studies as well as laboratory data supports the anticancer properties of garlic widely used as a medicinal herb and spice. Garlic and its organosulfur compounds (OSCs) appear to exert their anticarcinogenic effects through multiple mechanisms that include modulation of carcinogen metabolism, inhibition of DNA adduct formation, upregulation of antioxidant defences and DNA repair systems, and suppression of cell proliferation by blocking cell cycle progression and/or inducing apoptosis. Since multiple signaling pathways are dysfunctional in cancer and new oncogenic mutations accumulate with carcinogenic progression, dietary agents such as garlic with its rich array of bioactive OSCs that modulate cancer cascades offer promise as potential chemopreventive and chemotherapeutic agents.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India. s_nagini@yahoo.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18393790

Citation

Nagini, Siddavaram. "Cancer Chemoprevention By Garlic and Its Organosulfur Compounds-panacea or Promise?" Anti-cancer Agents in Medicinal Chemistry, vol. 8, no. 3, 2008, pp. 313-21.
Nagini S. Cancer chemoprevention by garlic and its organosulfur compounds-panacea or promise? Anticancer Agents Med Chem. 2008;8(3):313-21.
Nagini, S. (2008). Cancer chemoprevention by garlic and its organosulfur compounds-panacea or promise? Anti-cancer Agents in Medicinal Chemistry, 8(3), pp. 313-21.
Nagini S. Cancer Chemoprevention By Garlic and Its Organosulfur Compounds-panacea or Promise. Anticancer Agents Med Chem. 2008;8(3):313-21. PubMed PMID: 18393790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer chemoprevention by garlic and its organosulfur compounds-panacea or promise? A1 - Nagini,Siddavaram, PY - 2008/4/9/pubmed PY - 2008/5/16/medline PY - 2008/4/9/entrez SP - 313 EP - 21 JF - Anti-cancer agents in medicinal chemistry JO - Anticancer Agents Med Chem VL - 8 IS - 3 N2 - Of late medicinal plants and functional foods rich in bioactive phytochemicals have received growing attention as potential agents for cancer chemoprevention. Accumulating evidence from epidemiological studies as well as laboratory data supports the anticancer properties of garlic widely used as a medicinal herb and spice. Garlic and its organosulfur compounds (OSCs) appear to exert their anticarcinogenic effects through multiple mechanisms that include modulation of carcinogen metabolism, inhibition of DNA adduct formation, upregulation of antioxidant defences and DNA repair systems, and suppression of cell proliferation by blocking cell cycle progression and/or inducing apoptosis. Since multiple signaling pathways are dysfunctional in cancer and new oncogenic mutations accumulate with carcinogenic progression, dietary agents such as garlic with its rich array of bioactive OSCs that modulate cancer cascades offer promise as potential chemopreventive and chemotherapeutic agents. SN - 1871-5206 UR - https://www.unboundmedicine.com/medline/citation/18393790/Cancer_chemoprevention_by_garlic_and_its_organosulfur_compounds_panacea_or_promise L2 - http://www.eurekaselect.com/66639/article DB - PRIME DP - Unbound Medicine ER -