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Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia.
Emerg Infect Dis. 2008 Apr; 14(4):617-25.EI

Abstract

Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients' serum. The clinical severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe.

Authors+Show Affiliations

Charité School of Medicine, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18394280

Citation

Klempa, Boris, et al. "Hemorrhagic Fever With Renal Syndrome Caused By 2 Lineages of Dobrava Hantavirus, Russia." Emerging Infectious Diseases, vol. 14, no. 4, 2008, pp. 617-25.
Klempa B, Tkachenko EA, Dzagurova TK, et al. Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia. Emerging Infect Dis. 2008;14(4):617-25.
Klempa, B., Tkachenko, E. A., Dzagurova, T. K., Yunicheva, Y. V., Morozov, V. G., Okulova, N. M., Slyusareva, G. P., Smirnov, A., & Kruger, D. H. (2008). Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia. Emerging Infectious Diseases, 14(4), 617-25. https://doi.org/10.3201/eid1404.071310
Klempa B, et al. Hemorrhagic Fever With Renal Syndrome Caused By 2 Lineages of Dobrava Hantavirus, Russia. Emerging Infect Dis. 2008;14(4):617-25. PubMed PMID: 18394280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia. AU - Klempa,Boris, AU - Tkachenko,Evgeniy A, AU - Dzagurova,Tamara K, AU - Yunicheva,Yulia V, AU - Morozov,Vyacheslav G, AU - Okulova,Natalia M, AU - Slyusareva,Galina P, AU - Smirnov,Aleksey, AU - Kruger,Detlev H, PY - 2008/4/9/pubmed PY - 2008/8/8/medline PY - 2008/4/9/entrez SP - 617 EP - 25 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 14 IS - 4 N2 - Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients' serum. The clinical severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/18394280/Hemorrhagic_fever_with_renal_syndrome_caused_by_2_lineages_of_Dobrava_hantavirus_Russia_ L2 - https://dx.doi.org/10.3201/eid1404.071310 DB - PRIME DP - Unbound Medicine ER -