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Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols.
Arch Biochem Biophys. 2008 Aug 15; 476(2):145-51.AB

Abstract

Mechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-catecholamine conjugates may contribute. In the present study, peroxynitrite was observed to generate both 2-S- and 5-S-cysteinyl-dopamine and a dihydrobenzothiazine species, DHBT-1, following the reaction of dopamine with l-cysteine. The formation of 5-S-cysteinyl-dopamine and DHBT-1 in the presence of peroxynitrite induced significant neuronal injury. Pre-treatment of cortical neurons with pelargonidin, quercetin, hesperetin, caffeic acid, the 4'-O-Me derivatives of catechin and epicatechin (0.1-3.0 microM) resulted in concentration dependant protection against 5-S-cysteinyl-dopamine-induced neurotoxicity. These data suggest that polyphenols may protect against neuronal injury induced by endogenous neurotoxins relevant to the aetiology of the Parkinson disease.

Authors+Show Affiliations

Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, P.O. Box 226, Whiteknights Campus, Reading RG6 6AP, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18394421

Citation

Vauzour, David, et al. "Peroxynitrite Induced Formation of the Neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson's Disease and Protection By Polyphenols." Archives of Biochemistry and Biophysics, vol. 476, no. 2, 2008, pp. 145-51.
Vauzour D, Ravaioli G, Vafeiadou K, et al. Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. Arch Biochem Biophys. 2008;476(2):145-51.
Vauzour, D., Ravaioli, G., Vafeiadou, K., Rodriguez-Mateos, A., Angeloni, C., & Spencer, J. P. (2008). Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. Archives of Biochemistry and Biophysics, 476(2), 145-51. https://doi.org/10.1016/j.abb.2008.03.011
Vauzour D, et al. Peroxynitrite Induced Formation of the Neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson's Disease and Protection By Polyphenols. Arch Biochem Biophys. 2008 Aug 15;476(2):145-51. PubMed PMID: 18394421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. AU - Vauzour,David, AU - Ravaioli,Giulia, AU - Vafeiadou,Katerina, AU - Rodriguez-Mateos,Ana, AU - Angeloni,Cristina, AU - Spencer,Jeremy P E, Y1 - 2008/03/22/ PY - 2008/01/14/received PY - 2008/02/25/revised PY - 2008/03/14/accepted PY - 2008/4/9/pubmed PY - 2008/8/20/medline PY - 2008/4/9/entrez SP - 145 EP - 51 JF - Archives of biochemistry and biophysics JO - Arch Biochem Biophys VL - 476 IS - 2 N2 - Mechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-catecholamine conjugates may contribute. In the present study, peroxynitrite was observed to generate both 2-S- and 5-S-cysteinyl-dopamine and a dihydrobenzothiazine species, DHBT-1, following the reaction of dopamine with l-cysteine. The formation of 5-S-cysteinyl-dopamine and DHBT-1 in the presence of peroxynitrite induced significant neuronal injury. Pre-treatment of cortical neurons with pelargonidin, quercetin, hesperetin, caffeic acid, the 4'-O-Me derivatives of catechin and epicatechin (0.1-3.0 microM) resulted in concentration dependant protection against 5-S-cysteinyl-dopamine-induced neurotoxicity. These data suggest that polyphenols may protect against neuronal injury induced by endogenous neurotoxins relevant to the aetiology of the Parkinson disease. SN - 1096-0384 UR - https://www.unboundmedicine.com/medline/citation/18394421/Peroxynitrite_induced_formation_of_the_neurotoxins_5_S_cysteinyl_dopamine_and_DHBT_1:_implications_for_Parkinson's_disease_and_protection_by_polyphenols_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9861(08)00149-5 DB - PRIME DP - Unbound Medicine ER -