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Regulation of mRNP dynamics along the export pathway.
FEBS Lett. 2008 Jun 18; 582(14):1987-96.FL

Abstract

The transcription of mRNA is tightly coupled to the concomitant recruitment of mRNA processing and export factors, resulting in the formation of mature and export competent mRNP complexes. This interconnection in gene expression implies extensive spatio-temporal control of mRNP dynamics to prevent mRNA export factors bound to pre-mRNA from functioning at the incorrect time and exporting nascent or incompletely processed pre-mRNAs. Recent discoveries provide molecular understanding of how a broad range of post-translational modifications together with RNA-dependent ATPases coordinate proteins acting at different steps and regulate mRNP assembly and export.

Authors+Show Affiliations

Department of Cell Biology, University of Geneva, 30 Quai E. Ansermet, 1211 Geneva 4, Switzerland.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18394429

Citation

Iglesias, Nahid, and Françoise Stutz. "Regulation of mRNP Dynamics Along the Export Pathway." FEBS Letters, vol. 582, no. 14, 2008, pp. 1987-96.
Iglesias N, Stutz F. Regulation of mRNP dynamics along the export pathway. FEBS Lett. 2008;582(14):1987-96.
Iglesias, N., & Stutz, F. (2008). Regulation of mRNP dynamics along the export pathway. FEBS Letters, 582(14), 1987-96. https://doi.org/10.1016/j.febslet.2008.03.038
Iglesias N, Stutz F. Regulation of mRNP Dynamics Along the Export Pathway. FEBS Lett. 2008 Jun 18;582(14):1987-96. PubMed PMID: 18394429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of mRNP dynamics along the export pathway. AU - Iglesias,Nahid, AU - Stutz,Françoise, Y1 - 2008/04/03/ PY - 2008/02/28/received PY - 2008/03/25/revised PY - 2008/03/26/accepted PY - 2008/4/9/pubmed PY - 2008/8/8/medline PY - 2008/4/9/entrez SP - 1987 EP - 96 JF - FEBS letters JO - FEBS Lett VL - 582 IS - 14 N2 - The transcription of mRNA is tightly coupled to the concomitant recruitment of mRNA processing and export factors, resulting in the formation of mature and export competent mRNP complexes. This interconnection in gene expression implies extensive spatio-temporal control of mRNP dynamics to prevent mRNA export factors bound to pre-mRNA from functioning at the incorrect time and exporting nascent or incompletely processed pre-mRNAs. Recent discoveries provide molecular understanding of how a broad range of post-translational modifications together with RNA-dependent ATPases coordinate proteins acting at different steps and regulate mRNP assembly and export. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/18394429/Regulation_of_mRNP_dynamics_along_the_export_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-5793(08)00285-8 DB - PRIME DP - Unbound Medicine ER -