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Morphologic changes in acute central serous chorioretinopathy evaluated by fourier-domain optical coherence tomography.
Ophthalmology. 2008 Sep; 115(9):1494-500, 1500.e1-2.O

Abstract

OBJECTIVE

To investigate morphologic alterations around fluorescein leakage sites using Fourier-domain optical coherence tomography (FD OCT) in acute central serous chorioretinopathy (CSC).

DESIGN

Observational case series.

PARTICIPANTS

Twenty-one eyes with acute CSC with subjective symptoms for under 3 months.

METHODS

Patients underwent measurement of visual acuity, fundus observations, and FD OCT examinations at every visit with the intervals of 2 to 4 weeks until subretinal fluid (SRF) resolved. Fluorescein angiography was performed at baseline to confirm dye leakage sites. Horizontal and vertical OCT scans (B-scans and consecutive raster scans) of the fovea and fluorescein leakage sites were obtained.

MAIN OUTCOME MEASURES

Morphologic changes in the retinal pigment epithelium (RPE), detached retina, and subretinal space around the leakage sites were evaluated repeatedly during follow-up.

RESULTS

The mean period between baseline and the final examination was 108 days (mean no. of examinations, 3.9). Among 23 leakage sites in 21 eyes, FD OCT showed RPE abnormalities in 22 (96%) sites (14 sites [61%] with a pigment epithelial detachment [PED] and 8 [35%] with a protruding or irregular RPE layer). Fibrinous exudates in the subretinal space and sagging/dipping of the posterior layer of the neurosensory retina above the leakage sites were seen at 12 (52%) and 10 (43%) leakage points, respectively. An RPE defect at the edge of or within the PED was observed in 5 leakage sites (22%); in 2 of these, a defect was detectable after the SRF decreased. The posterior surface of the detached retina was smooth in 17 eyes (81%) and granulated in 4 eyes (19%) (mean duration of subjective symptoms, 10 days and 42 days, respectively). The smooth posterior detached retina became granulated in the presence of residual SRF. A PED remained at the 5 leakage sites in 5 eyes (22%) despite SRF resolution.

CONCLUSIONS

Fourier-domain OCT examinations showed detailed morphologic changes in eyes with acute CSC including an RPE defect within the PED at a leakage site through which fluid might pass from the sub-RPE to the subretinal area. Fourier-domain OCT findings may offer new information to facilitate understanding of the mechanisms of acute CSC.

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Authors+Show Affiliations

Fujimoto H
Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan.
Gomi F
No affiliation info available
Wakabayashi T
No affiliation info available
Sawa M
No affiliation info available
Tsujikawa M
No affiliation info available
Tano Y
No affiliation info available

MeSH

Acute DiseaseAdultAgedBlood-Retinal BarrierCapillary PermeabilityChoroidChoroid DiseasesExudates and TransudatesFemaleFluoresceinFluorescein AngiographyFourier AnalysisHumansMaleMiddle AgedPigment Epithelium of EyeProspective StudiesRetinal DiseasesSerumTomography, Optical CoherenceVisual Acuity

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18394706

Clinical Trial Links

Eplerenone for Central Serous Chorioretinopathy
Short-Term Oral Mifepristone for Central Serous Chorioretinopathy

Citation

Fujimoto, Hisataka, et al. "Morphologic Changes in Acute Central Serous Chorioretinopathy Evaluated By Fourier-domain Optical Coherence Tomography." Ophthalmology, vol. 115, no. 9, 2008, pp. 1494-500, 1500.e1-2.
Fujimoto H, Gomi F, Wakabayashi T, et al. Morphologic changes in acute central serous chorioretinopathy evaluated by fourier-domain optical coherence tomography. Ophthalmology. 2008;115(9):1494-500, 1500.e1-2.
Fujimoto, H., Gomi, F., Wakabayashi, T., Sawa, M., Tsujikawa, M., & Tano, Y. (2008). Morphologic changes in acute central serous chorioretinopathy evaluated by fourier-domain optical coherence tomography. Ophthalmology, 115(9), 1494-500, e1-2. https://doi.org/10.1016/j.ophtha.2008.01.021
Fujimoto H, et al. Morphologic Changes in Acute Central Serous Chorioretinopathy Evaluated By Fourier-domain Optical Coherence Tomography. Ophthalmology. 2008;115(9):1494-500, 1500.e1-2. PubMed PMID: 18394706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphologic changes in acute central serous chorioretinopathy evaluated by fourier-domain optical coherence tomography. AU - Fujimoto,Hisataka, AU - Gomi,Fumi, AU - Wakabayashi,Taku, AU - Sawa,Miki, AU - Tsujikawa,Motokazu, AU - Tano,Yasuo, Y1 - 2008/04/18/ PY - 2007/07/03/received PY - 2007/11/10/revised PY - 2008/01/23/accepted PY - 2008/4/9/pubmed PY - 2008/9/13/medline PY - 2008/4/9/entrez SP - 1494-500, 1500.e1-2 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 9 N2 - OBJECTIVE: To investigate morphologic alterations around fluorescein leakage sites using Fourier-domain optical coherence tomography (FD OCT) in acute central serous chorioretinopathy (CSC). DESIGN: Observational case series. PARTICIPANTS: Twenty-one eyes with acute CSC with subjective symptoms for under 3 months. METHODS: Patients underwent measurement of visual acuity, fundus observations, and FD OCT examinations at every visit with the intervals of 2 to 4 weeks until subretinal fluid (SRF) resolved. Fluorescein angiography was performed at baseline to confirm dye leakage sites. Horizontal and vertical OCT scans (B-scans and consecutive raster scans) of the fovea and fluorescein leakage sites were obtained. MAIN OUTCOME MEASURES: Morphologic changes in the retinal pigment epithelium (RPE), detached retina, and subretinal space around the leakage sites were evaluated repeatedly during follow-up. RESULTS: The mean period between baseline and the final examination was 108 days (mean no. of examinations, 3.9). Among 23 leakage sites in 21 eyes, FD OCT showed RPE abnormalities in 22 (96%) sites (14 sites [61%] with a pigment epithelial detachment [PED] and 8 [35%] with a protruding or irregular RPE layer). Fibrinous exudates in the subretinal space and sagging/dipping of the posterior layer of the neurosensory retina above the leakage sites were seen at 12 (52%) and 10 (43%) leakage points, respectively. An RPE defect at the edge of or within the PED was observed in 5 leakage sites (22%); in 2 of these, a defect was detectable after the SRF decreased. The posterior surface of the detached retina was smooth in 17 eyes (81%) and granulated in 4 eyes (19%) (mean duration of subjective symptoms, 10 days and 42 days, respectively). The smooth posterior detached retina became granulated in the presence of residual SRF. A PED remained at the 5 leakage sites in 5 eyes (22%) despite SRF resolution. CONCLUSIONS: Fourier-domain OCT examinations showed detailed morphologic changes in eyes with acute CSC including an RPE defect within the PED at a leakage site through which fluid might pass from the sub-RPE to the subretinal area. Fourier-domain OCT findings may offer new information to facilitate understanding of the mechanisms of acute CSC. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/18394706/Morphologic_changes_in_acute_central_serous_chorioretinopathy_evaluated_by_fourier_domain_optical_coherence_tomography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(08)00085-7 DB - PRIME DP - Unbound Medicine ER -