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Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry.
J Pharm Biomed Anal. 2008 Jul 15; 47(3):516-25.JP

Abstract

A simple and rapid method has been established for the screening of the main phenolic compounds in Artemisia annua by LC-DAD-ESI-MS(n). A total of 40 phenolic compounds were identified or tentatively characterized in the methanol extract of A. annua, including 8 C-glycosyl flavonoids, 5 O-glycosyl flavonoids, 3 flavonoid aglycones, 21 quinic acid derivatives, 2 benzoicacid glucosides and 1 coumarin. The C-glycosyl flavonoids were reported from A. annua for the first time and they were found to be a new type of main constituents, and might be responsible for its antioxidant and antiviral activity. Quinic acid derivatives were also found to be the major constituents of A. annua.

Authors+Show Affiliations

The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100083, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18394841

Citation

Han, Jian, et al. "Characterization of Phenolic Compounds in the Chinese Herbal Drug Artemisia Annua By Liquid Chromatography Coupled to Electrospray Ionization Mass Spectrometry." Journal of Pharmaceutical and Biomedical Analysis, vol. 47, no. 3, 2008, pp. 516-25.
Han J, Ye M, Qiao X, et al. Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry. J Pharm Biomed Anal. 2008;47(3):516-25.
Han, J., Ye, M., Qiao, X., Xu, M., Wang, B. R., & Guo, D. A. (2008). Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 47(3), 516-25. https://doi.org/10.1016/j.jpba.2008.02.013
Han J, et al. Characterization of Phenolic Compounds in the Chinese Herbal Drug Artemisia Annua By Liquid Chromatography Coupled to Electrospray Ionization Mass Spectrometry. J Pharm Biomed Anal. 2008 Jul 15;47(3):516-25. PubMed PMID: 18394841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry. AU - Han,Jian, AU - Ye,Min, AU - Qiao,Xue, AU - Xu,Man, AU - Wang,Bao-Rong, AU - Guo,De-An, Y1 - 2008/03/10/ PY - 2007/10/26/received PY - 2008/01/31/revised PY - 2008/02/06/accepted PY - 2008/4/9/pubmed PY - 2008/9/10/medline PY - 2008/4/9/entrez SP - 516 EP - 25 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 47 IS - 3 N2 - A simple and rapid method has been established for the screening of the main phenolic compounds in Artemisia annua by LC-DAD-ESI-MS(n). A total of 40 phenolic compounds were identified or tentatively characterized in the methanol extract of A. annua, including 8 C-glycosyl flavonoids, 5 O-glycosyl flavonoids, 3 flavonoid aglycones, 21 quinic acid derivatives, 2 benzoicacid glucosides and 1 coumarin. The C-glycosyl flavonoids were reported from A. annua for the first time and they were found to be a new type of main constituents, and might be responsible for its antioxidant and antiviral activity. Quinic acid derivatives were also found to be the major constituents of A. annua. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/18394841/Characterization_of_phenolic_compounds_in_the_Chinese_herbal_drug_Artemisia_annua_by_liquid_chromatography_coupled_to_electrospray_ionization_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(08)00101-5 DB - PRIME DP - Unbound Medicine ER -