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Cerebrospinal fluid levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in subacute sclerosing panencephalitis.
J Infect. 2008 May; 56(5):376-80.JI

Abstract

OBJECTIVES

To investigate the brain inflammation and damage in subacute sclerosing panencephalitis (SSPE), the cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were determined in SSPE patients.

METHODS

CSF MMP-9 and TIMP-1 levels were measured in 23 patients with SSPE in Papua New Guinea by ELISA.

RESULTS

CSF MMP-9 levels and MMP-9/TIMP-1 ratios of SSPE patients were significantly higher than controls (p<0.001 and p=0.005, respectively). There were no significant differences in CSF TIMP-1 levels between SSPE patients and controls.

CONCLUSIONS

Previous studies suggested that CSF MMP-9 levels reflect inflammatory damage to the brain. Our findings suggest that the MMP-9 level in CSF is an indicator of inflammatory damage to the brain in SSPE.

Authors+Show Affiliations

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. ichiyama@yamaguchi-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18395263

Citation

Ichiyama, Takashi, et al. "Cerebrospinal Fluid Levels of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Subacute Sclerosing Panencephalitis." The Journal of Infection, vol. 56, no. 5, 2008, pp. 376-80.
Ichiyama T, Matsushige T, Siba P, et al. Cerebrospinal fluid levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in subacute sclerosing panencephalitis. J Infect. 2008;56(5):376-80.
Ichiyama, T., Matsushige, T., Siba, P., Suarkia, D., Takasu, T., Miki, K., & Furukawa, S. (2008). Cerebrospinal fluid levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in subacute sclerosing panencephalitis. The Journal of Infection, 56(5), 376-80. https://doi.org/10.1016/j.jinf.2008.02.014
Ichiyama T, et al. Cerebrospinal Fluid Levels of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in Subacute Sclerosing Panencephalitis. J Infect. 2008;56(5):376-80. PubMed PMID: 18395263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in subacute sclerosing panencephalitis. AU - Ichiyama,Takashi, AU - Matsushige,Takeshi, AU - Siba,Peter, AU - Suarkia,Dagwin, AU - Takasu,Toshiaki, AU - Miki,Kenji, AU - Furukawa,Susumu, Y1 - 2008/04/18/ PY - 2007/12/30/received PY - 2008/02/21/revised PY - 2008/02/22/accepted PY - 2008/4/9/pubmed PY - 2008/6/21/medline PY - 2008/4/9/entrez SP - 376 EP - 80 JF - The Journal of infection JO - J Infect VL - 56 IS - 5 N2 - OBJECTIVES: To investigate the brain inflammation and damage in subacute sclerosing panencephalitis (SSPE), the cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were determined in SSPE patients. METHODS: CSF MMP-9 and TIMP-1 levels were measured in 23 patients with SSPE in Papua New Guinea by ELISA. RESULTS: CSF MMP-9 levels and MMP-9/TIMP-1 ratios of SSPE patients were significantly higher than controls (p<0.001 and p=0.005, respectively). There were no significant differences in CSF TIMP-1 levels between SSPE patients and controls. CONCLUSIONS: Previous studies suggested that CSF MMP-9 levels reflect inflammatory damage to the brain. Our findings suggest that the MMP-9 level in CSF is an indicator of inflammatory damage to the brain in SSPE. SN - 1532-2742 UR - https://www.unboundmedicine.com/medline/citation/18395263/Cerebrospinal_fluid_levels_of_matrix_metalloproteinase_9_and_tissue_inhibitor_of_metalloproteinase_1_in_subacute_sclerosing_panencephalitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(08)00099-6 DB - PRIME DP - Unbound Medicine ER -