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Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones.
Int J Gynaecol Obstet 2008; 102(1):44-9IJ

Abstract

OBJECTIVE

To evaluate the effect of soy isoflavones on menopausal symptoms in women who do and who do not produce equol, a daidzein metabolite.

METHOD

A randomized, double-blind, placebo-controlled clinical trial was conducted over 6 months with 96 healthy menopausal women. After taking take 135 mg of isoflavones daily for 1 week, the women in the study group were assigned to the equol-producing (EP) or the non-EP group according to the presence or absence of equol in their urine. Menopausal symptoms were evaluated using a modified Kupperman Index.

RESULT

Compared with the placebo group, the scores for hot flashes and excessive sweating were significantly reduced after 3 months, and the scores for weakness, palpitations, limb paresthesia, and total symptoms after 6 months, in the EP group only.

CONCLUSIONS

Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Taiwan Adventist Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18395723

Citation

Jou, Hei-Jen, et al. "Effect of Intestinal Production of Equol On Menopausal Symptoms in Women Treated With Soy Isoflavones." International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, vol. 102, no. 1, 2008, pp. 44-9.
Jou HJ, Wu SC, Chang FW, et al. Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones. Int J Gynaecol Obstet. 2008;102(1):44-9.
Jou, H. J., Wu, S. C., Chang, F. W., Ling, P. Y., Chu, K. S., & Wu, W. H. (2008). Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, 102(1), pp. 44-9. doi:10.1016/j.ijgo.2008.01.028.
Jou HJ, et al. Effect of Intestinal Production of Equol On Menopausal Symptoms in Women Treated With Soy Isoflavones. Int J Gynaecol Obstet. 2008;102(1):44-9. PubMed PMID: 18395723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones. AU - Jou,Hei-Jen, AU - Wu,Shiao-Chi, AU - Chang,Fang-Wei, AU - Ling,Pei-Ying, AU - Chu,Kung Shen, AU - Wu,Wen-Huey, Y1 - 2008/04/08/ PY - 2007/10/17/received PY - 2008/01/12/revised PY - 2008/01/15/accepted PY - 2008/4/9/pubmed PY - 2008/11/14/medline PY - 2008/4/9/entrez SP - 44 EP - 9 JF - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JO - Int J Gynaecol Obstet VL - 102 IS - 1 N2 - OBJECTIVE: To evaluate the effect of soy isoflavones on menopausal symptoms in women who do and who do not produce equol, a daidzein metabolite. METHOD: A randomized, double-blind, placebo-controlled clinical trial was conducted over 6 months with 96 healthy menopausal women. After taking take 135 mg of isoflavones daily for 1 week, the women in the study group were assigned to the equol-producing (EP) or the non-EP group according to the presence or absence of equol in their urine. Menopausal symptoms were evaluated using a modified Kupperman Index. RESULT: Compared with the placebo group, the scores for hot flashes and excessive sweating were significantly reduced after 3 months, and the scores for weakness, palpitations, limb paresthesia, and total symptoms after 6 months, in the EP group only. CONCLUSIONS: Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol. SN - 0020-7292 UR - https://www.unboundmedicine.com/medline/citation/18395723/Effect_of_intestinal_production_of_equol_on_menopausal_symptoms_in_women_treated_with_soy_isoflavones_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0020-7292(08)00072-6 DB - PRIME DP - Unbound Medicine ER -