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Level of protection of chickens against highly pathogenic H5 avian influenza virus with Newcastle disease virus based live attenuated vector vaccine depends on homology of H5 sequence between vaccine and challenge virus.
Vaccine. 2008 May 02; 26(19):2307-13.V

Abstract

Vaccination of poultry against avian influenza is of high priority, in particular after the dramatic spread of subtype H5N1 in Asia, Africa and Europe. Newcastle disease virus (NDV) has been developed as a vector for the expression of the main immunogen of avian influenza virus, hemagglutinin (HA). An NDV vector based vaccine has several advantages. It allows easy serological differentiation between infected and vaccinated animals by the detection of antibodies against non-HA influenza proteins. Moreover, it can be administered easily to large numbers of animals by spray or drinking water. We recently showed that chickens could be protected against infection with highly pathogenic avian influenza virus (HPAIV) A/chicken/Italy/8/98 (H5N2) after immunization with a recombinant Newcastle disease virus, NDVH5m, which expresses the homologous hemagglutinin. Here, we describe that immunization with NDVH5m conferred only partial protection against lethal infection with heterologous HPAIV A/duck/Vietnam/TG24-01/05 (H5N1). Comparison of amino acid sequences of both H5 proteins showed only 93.6% amino acid identity. Therefore, a new NDV recombinant (NDVH5Vm) was generated which expresses the H5 protein of HPAIV A/chicken/Vietnam/P41/05 (H5N1). This recombinant virus protected chickens against lethal infection with HPAIV H5N1 (Vietnam) already after one immunization. Our data thus show that application of a vector-based vaccine in the control of influenza may require adaptation of the vaccine to currently circulating viruses.

Authors+Show Affiliations

Institute of Molecular Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, D-17493 Greifswald-Insel Riems, Germany. angela.roemer-oberdoerfer@fli.bund.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18395947

Citation

Römer-Oberdörfer, Angela, et al. "Level of Protection of Chickens Against Highly Pathogenic H5 Avian Influenza Virus With Newcastle Disease Virus Based Live Attenuated Vector Vaccine Depends On Homology of H5 Sequence Between Vaccine and Challenge Virus." Vaccine, vol. 26, no. 19, 2008, pp. 2307-13.
Römer-Oberdörfer A, Veits J, Helferich D, et al. Level of protection of chickens against highly pathogenic H5 avian influenza virus with Newcastle disease virus based live attenuated vector vaccine depends on homology of H5 sequence between vaccine and challenge virus. Vaccine. 2008;26(19):2307-13.
Römer-Oberdörfer, A., Veits, J., Helferich, D., & Mettenleiter, T. C. (2008). Level of protection of chickens against highly pathogenic H5 avian influenza virus with Newcastle disease virus based live attenuated vector vaccine depends on homology of H5 sequence between vaccine and challenge virus. Vaccine, 26(19), 2307-13. https://doi.org/10.1016/j.vaccine.2008.02.061
Römer-Oberdörfer A, et al. Level of Protection of Chickens Against Highly Pathogenic H5 Avian Influenza Virus With Newcastle Disease Virus Based Live Attenuated Vector Vaccine Depends On Homology of H5 Sequence Between Vaccine and Challenge Virus. Vaccine. 2008 May 2;26(19):2307-13. PubMed PMID: 18395947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Level of protection of chickens against highly pathogenic H5 avian influenza virus with Newcastle disease virus based live attenuated vector vaccine depends on homology of H5 sequence between vaccine and challenge virus. AU - Römer-Oberdörfer,Angela, AU - Veits,Jutta, AU - Helferich,Dorothee, AU - Mettenleiter,Thomas C, Y1 - 2008/03/18/ PY - 2007/08/29/received PY - 2008/02/21/revised PY - 2008/02/28/accepted PY - 2008/4/9/pubmed PY - 2008/7/25/medline PY - 2008/4/9/entrez SP - 2307 EP - 13 JF - Vaccine JO - Vaccine VL - 26 IS - 19 N2 - Vaccination of poultry against avian influenza is of high priority, in particular after the dramatic spread of subtype H5N1 in Asia, Africa and Europe. Newcastle disease virus (NDV) has been developed as a vector for the expression of the main immunogen of avian influenza virus, hemagglutinin (HA). An NDV vector based vaccine has several advantages. It allows easy serological differentiation between infected and vaccinated animals by the detection of antibodies against non-HA influenza proteins. Moreover, it can be administered easily to large numbers of animals by spray or drinking water. We recently showed that chickens could be protected against infection with highly pathogenic avian influenza virus (HPAIV) A/chicken/Italy/8/98 (H5N2) after immunization with a recombinant Newcastle disease virus, NDVH5m, which expresses the homologous hemagglutinin. Here, we describe that immunization with NDVH5m conferred only partial protection against lethal infection with heterologous HPAIV A/duck/Vietnam/TG24-01/05 (H5N1). Comparison of amino acid sequences of both H5 proteins showed only 93.6% amino acid identity. Therefore, a new NDV recombinant (NDVH5Vm) was generated which expresses the H5 protein of HPAIV A/chicken/Vietnam/P41/05 (H5N1). This recombinant virus protected chickens against lethal infection with HPAIV H5N1 (Vietnam) already after one immunization. Our data thus show that application of a vector-based vaccine in the control of influenza may require adaptation of the vaccine to currently circulating viruses. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/18395947/Level_of_protection_of_chickens_against_highly_pathogenic_H5_avian_influenza_virus_with_Newcastle_disease_virus_based_live_attenuated_vector_vaccine_depends_on_homology_of_H5_sequence_between_vaccine_and_challenge_virus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(08)00276-4 DB - PRIME DP - Unbound Medicine ER -