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Review article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver disease.
Aliment Pharmacol Ther 2008; 28(1):13-24AP

Abstract

BACKGROUND

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of paediatric liver disease. Similar to NAFLD in adults, NAFLD in children is associated with obesity and insulin resistance and requires liver histology for diagnosis and staging. However, significant histological differences exist between adult and paediatric NAFLD to warrant caution in extrapolation of adult data.

AIM

To review the available data on the epidemiology, pathogenesis, diagnosis and treatment of paediatric NAFLD.

METHODS

Relevant articles were identified by Medline searches using the keywords: nonalcoholic fatty liver disease, steatohepatitis, obesity and children.

RESULTS

The rise in childhood obesity has been accompanied by an increase in paediatric NAFLD. Age, gender and race/ethnicity are significant determinants of risk, and sex hormones, insulin sensitivity and adipocytokines are implicated in the pathogenesis of paediatric NAFLD. There is no consensus for treatment of NAFLD; however, data suggest that diet, exercise and some pharmacological therapies may be of benefit.

CONCLUSIONS

To evaluate and effectively treat paediatric NAFLD, the pathophysiology and natural history of the disease should be clarified and non-invasive methods for screening, diagnosis, and longitudinal assessment developed. Randomized, controlled, double-blind trials of pharmacological therapies in children with biopsy-proven disease are necessary.

Authors+Show Affiliations

Department of Pediatrics, University of California, San Diego, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18397387

Citation

Barshop, N J., et al. "Review Article: Epidemiology, Pathogenesis and Potential Treatments of Paediatric Non-alcoholic Fatty Liver Disease." Alimentary Pharmacology & Therapeutics, vol. 28, no. 1, 2008, pp. 13-24.
Barshop NJ, Sirlin CB, Schwimmer JB, et al. Review article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2008;28(1):13-24.
Barshop, N. J., Sirlin, C. B., Schwimmer, J. B., & Lavine, J. E. (2008). Review article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver disease. Alimentary Pharmacology & Therapeutics, 28(1), pp. 13-24. doi:10.1111/j.1365-2036.2008.03703.x.
Barshop NJ, et al. Review Article: Epidemiology, Pathogenesis and Potential Treatments of Paediatric Non-alcoholic Fatty Liver Disease. Aliment Pharmacol Ther. 2008;28(1):13-24. PubMed PMID: 18397387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver disease. AU - Barshop,N J, AU - Sirlin,C B, AU - Schwimmer,J B, AU - Lavine,J E, Y1 - 2008/04/04/ PY - 2008/4/10/pubmed PY - 2008/12/17/medline PY - 2008/4/10/entrez SP - 13 EP - 24 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 28 IS - 1 N2 - BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of paediatric liver disease. Similar to NAFLD in adults, NAFLD in children is associated with obesity and insulin resistance and requires liver histology for diagnosis and staging. However, significant histological differences exist between adult and paediatric NAFLD to warrant caution in extrapolation of adult data. AIM: To review the available data on the epidemiology, pathogenesis, diagnosis and treatment of paediatric NAFLD. METHODS: Relevant articles were identified by Medline searches using the keywords: nonalcoholic fatty liver disease, steatohepatitis, obesity and children. RESULTS: The rise in childhood obesity has been accompanied by an increase in paediatric NAFLD. Age, gender and race/ethnicity are significant determinants of risk, and sex hormones, insulin sensitivity and adipocytokines are implicated in the pathogenesis of paediatric NAFLD. There is no consensus for treatment of NAFLD; however, data suggest that diet, exercise and some pharmacological therapies may be of benefit. CONCLUSIONS: To evaluate and effectively treat paediatric NAFLD, the pathophysiology and natural history of the disease should be clarified and non-invasive methods for screening, diagnosis, and longitudinal assessment developed. Randomized, controlled, double-blind trials of pharmacological therapies in children with biopsy-proven disease are necessary. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/18397387/Review_article:_epidemiology_pathogenesis_and_potential_treatments_of_paediatric_non_alcoholic_fatty_liver_disease_ L2 - https://doi.org/10.1111/j.1365-2036.2008.03703.x DB - PRIME DP - Unbound Medicine ER -