Tags

Type your tag names separated by a space and hit enter

Non-atopic asthma in children is related to maternal bronchial hyperreactivity.
Pediatr Allergy Immunol. 2008 May; 19(3):248-54.PA

Abstract

Data on the pathogenic mechanisms underlying the development of non-atopic asthma in children are scarce. Our aim was to evaluate the association and compare the atopic status, pulmonary functions, bronchial hyperresponsiveness and serum total immunoglobulin E (IgE) levels of parents of atopic and non-atopic asthmatic children by using objective methods. Fifty-one asthmatic children aged 4-16 yr and their parents were included into the study. Initially the American Thoracic Society's Respiratory Disease questionnaire inquiring data on symptoms of asthma, rhinitis and past medical history was filled in. Afterwards, skin prick test with aeroallergens, pulmonary function and methacholine bronchial provocation tests and serum sampling for total IgE level determinations were carried out. Bronchial hyperresponsiveness to methacholine was significantly more common in the mothers of non-atopic children compared to those of atopic ones, although no significant difference was observed in the skin prick test reactivity, pulmonary function test parameters and serum IgE levels. Questionnaire data revealed that the presence of asthmatic symptoms such as wheezing and phlegm and doctor-diagnosed asthma were more common in the mothers of non-atopic children. Meanwhile, asthmatic symptoms were also found to be significantly more common in fathers of non-atopic children. Logistic regression analyses revealed that maternal PC(20) was the only predictive factor for the risk of displaying non-allergic asthma in children. The results demonstrate that among the risk factors studied, maternal bronchial hyperreactivity was associated with the development of asthma in non-atopic children.

Authors+Show Affiliations

Division of Pediatric Allergy and Immunology, Marmara University, Istanbul, Turkey. cozdemir@superonline.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18397409

Citation

Ozdemir, Cevdet, et al. "Non-atopic Asthma in Children Is Related to Maternal Bronchial Hyperreactivity." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 19, no. 3, 2008, pp. 248-54.
Ozdemir C, Ceyhan BB, Yazi D, et al. Non-atopic asthma in children is related to maternal bronchial hyperreactivity. Pediatr Allergy Immunol. 2008;19(3):248-54.
Ozdemir, C., Ceyhan, B. B., Yazi, D., Eifan, A. O., Yesil, O., Bahceciler, N. N., & Barlan, I. B. (2008). Non-atopic asthma in children is related to maternal bronchial hyperreactivity. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 19(3), 248-54. https://doi.org/10.1111/j.1399-3038.2007.00620.x
Ozdemir C, et al. Non-atopic Asthma in Children Is Related to Maternal Bronchial Hyperreactivity. Pediatr Allergy Immunol. 2008;19(3):248-54. PubMed PMID: 18397409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-atopic asthma in children is related to maternal bronchial hyperreactivity. AU - Ozdemir,Cevdet, AU - Ceyhan,Berrin B, AU - Yazi,Didem, AU - Eifan,Aarif O, AU - Yesil,Ozlem, AU - Bahceciler,Nerin N, AU - Barlan,Isil B, PY - 2008/4/10/pubmed PY - 2008/6/3/medline PY - 2008/4/10/entrez SP - 248 EP - 54 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 19 IS - 3 N2 - Data on the pathogenic mechanisms underlying the development of non-atopic asthma in children are scarce. Our aim was to evaluate the association and compare the atopic status, pulmonary functions, bronchial hyperresponsiveness and serum total immunoglobulin E (IgE) levels of parents of atopic and non-atopic asthmatic children by using objective methods. Fifty-one asthmatic children aged 4-16 yr and their parents were included into the study. Initially the American Thoracic Society's Respiratory Disease questionnaire inquiring data on symptoms of asthma, rhinitis and past medical history was filled in. Afterwards, skin prick test with aeroallergens, pulmonary function and methacholine bronchial provocation tests and serum sampling for total IgE level determinations were carried out. Bronchial hyperresponsiveness to methacholine was significantly more common in the mothers of non-atopic children compared to those of atopic ones, although no significant difference was observed in the skin prick test reactivity, pulmonary function test parameters and serum IgE levels. Questionnaire data revealed that the presence of asthmatic symptoms such as wheezing and phlegm and doctor-diagnosed asthma were more common in the mothers of non-atopic children. Meanwhile, asthmatic symptoms were also found to be significantly more common in fathers of non-atopic children. Logistic regression analyses revealed that maternal PC(20) was the only predictive factor for the risk of displaying non-allergic asthma in children. The results demonstrate that among the risk factors studied, maternal bronchial hyperreactivity was associated with the development of asthma in non-atopic children. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/18397409/Non_atopic_asthma_in_children_is_related_to_maternal_bronchial_hyperreactivity_ L2 - https://doi.org/10.1111/j.1399-3038.2007.00620.x DB - PRIME DP - Unbound Medicine ER -