Tags

Type your tag names separated by a space and hit enter

[The role of JNK pathway in familial Parkinson's disease].
Postepy Biochem. 2007; 53(3):297-303.PB

Abstract

Parkinson's disease is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons in the substantia nigra. Among the many pathogenic mechanisms thought to contribute to the demise of these cells in sporadic cases of PD, oxidative stress has taken center stage due to extensive experimental evidence showing that dopamine- or MPTP-derived reactive oxygen species and oxidized dopamine metabolites may trigger toxicity through mitochondrial inhibition or deleterious modifications of biomolecules. In familial forms of PD, however, the involvement of toxic protein aggregation (synuclein), impairment of ubiquitin-proteosome system (parkin. and loss of antioxidative properties (DJ-1) has gained attention. Recently, JNK pathway has come to light that could link malfunction of mutated DJ-1, parkin, PINK1 and alpha-synuclein to the oxidative stress-triggered apoptosis, finally ascribing a common pathogenic mechanism to both the sporadic and familial forms of PD.

Authors+Show Affiliations

Zaklad Genetyki, Instytut Biologii Ogólnej i Molekularnej, Uniwersytet Mikołaja Kopernika w Toruniu. marek.jankowski@mensa.org.pl

Pub Type(s)

English Abstract
Journal Article
Review

Language

pol

PubMed ID

18399358

Citation

Jankowski, Marek. "[The Role of JNK Pathway in Familial Parkinson's Disease]." Postepy Biochemii, vol. 53, no. 3, 2007, pp. 297-303.
Jankowski M. [The role of JNK pathway in familial Parkinson's disease]. Postepy Biochem. 2007;53(3):297-303.
Jankowski, M. (2007). [The role of JNK pathway in familial Parkinson's disease]. Postepy Biochemii, 53(3), 297-303.
Jankowski M. [The Role of JNK Pathway in Familial Parkinson's Disease]. Postepy Biochem. 2007;53(3):297-303. PubMed PMID: 18399358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of JNK pathway in familial Parkinson's disease]. A1 - Jankowski,Marek, PY - 2008/4/11/pubmed PY - 2008/6/5/medline PY - 2008/4/11/entrez SP - 297 EP - 303 JF - Postepy biochemii JO - Postepy Biochem VL - 53 IS - 3 N2 - Parkinson's disease is a neurodegenerative disorder characterized by a dramatic loss of dopaminergic neurons in the substantia nigra. Among the many pathogenic mechanisms thought to contribute to the demise of these cells in sporadic cases of PD, oxidative stress has taken center stage due to extensive experimental evidence showing that dopamine- or MPTP-derived reactive oxygen species and oxidized dopamine metabolites may trigger toxicity through mitochondrial inhibition or deleterious modifications of biomolecules. In familial forms of PD, however, the involvement of toxic protein aggregation (synuclein), impairment of ubiquitin-proteosome system (parkin. and loss of antioxidative properties (DJ-1) has gained attention. Recently, JNK pathway has come to light that could link malfunction of mutated DJ-1, parkin, PINK1 and alpha-synuclein to the oxidative stress-triggered apoptosis, finally ascribing a common pathogenic mechanism to both the sporadic and familial forms of PD. SN - 0032-5422 UR - https://www.unboundmedicine.com/medline/citation/18399358/[The_role_of_JNK_pathway_in_familial_Parkinson's_disease]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.