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Glycemic load, glycemic index, and pancreatic cancer risk in the Netherlands Cohort Study.
Am J Clin Nutr. 2008 Apr; 87(4):970-7.AJ

Abstract

BACKGROUND

Recent studies of pancreatic cancer suggest a role for hyperinsulinemia in carcinogenesis. Because insulin is secreted in response to elevated blood glucose concentrations, dietary factors that increase these concentrations may be important in pancreatic carcinogenesis.

OBJECTIVE

The objective was to examine prospectively the relation between pancreatic cancer risk and dietary glycemic load (GL), overall glycemic index (GI), and intake of total carbohydrates and mono- and disaccharides.

DESIGN

The Netherlands Cohort Study consisted of 120,852 men and women who completed a baseline questionnaire in 1986. After 13.3 y of follow-up, 408 pancreatic cancer cases were detected, 66% of which were microscopically confirmed. A validated 150-item food-frequency questionnaire, completed at baseline, was used to calculate carbohydrate and mono- and disaccharide intakes and the GL and GI of the diet.

RESULTS

Dietary GL, GI, or intake of carbohydrates and mono- and disaccharides were not associated with pancreatic cancer risk in this cohort. Also, the associations were not modified by sex. Our results did not change after the analysis was restricted to microscopically confirmed pancreatic cancer cases or after individuals who reported a history of diabetes at baseline were excluded from the analyses.

CONCLUSIONS

Overall, our findings do not support the hypothesis that GL, GI, or intake of carbohydrates and mono- and disaccharides are positively associated with pancreatic cancer risk. This is in agreement with previous prospective studies that investigated the relation between GL and GI and pancreatic cancer risk.

Authors+Show Affiliations

Department of Epidemiology, Maastricht University, Maastricht, Netherlands. mirjam.heinen@epid.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18400721

Citation

Heinen, Mirjam M., et al. "Glycemic Load, Glycemic Index, and Pancreatic Cancer Risk in the Netherlands Cohort Study." The American Journal of Clinical Nutrition, vol. 87, no. 4, 2008, pp. 970-7.
Heinen MM, Verhage BA, Lumey L, et al. Glycemic load, glycemic index, and pancreatic cancer risk in the Netherlands Cohort Study. Am J Clin Nutr. 2008;87(4):970-7.
Heinen, M. M., Verhage, B. A., Lumey, L., Brants, H. A., Goldbohm, R. A., & van den Brandt, P. A. (2008). Glycemic load, glycemic index, and pancreatic cancer risk in the Netherlands Cohort Study. The American Journal of Clinical Nutrition, 87(4), 970-7.
Heinen MM, et al. Glycemic Load, Glycemic Index, and Pancreatic Cancer Risk in the Netherlands Cohort Study. Am J Clin Nutr. 2008;87(4):970-7. PubMed PMID: 18400721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycemic load, glycemic index, and pancreatic cancer risk in the Netherlands Cohort Study. AU - Heinen,Mirjam M, AU - Verhage,Bas Aj, AU - Lumey,Lh, AU - Brants,Henny Am, AU - Goldbohm,R Alexandra, AU - van den Brandt,Piet A, PY - 2008/4/11/pubmed PY - 2008/4/29/medline PY - 2008/4/11/entrez SP - 970 EP - 7 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 87 IS - 4 N2 - BACKGROUND: Recent studies of pancreatic cancer suggest a role for hyperinsulinemia in carcinogenesis. Because insulin is secreted in response to elevated blood glucose concentrations, dietary factors that increase these concentrations may be important in pancreatic carcinogenesis. OBJECTIVE: The objective was to examine prospectively the relation between pancreatic cancer risk and dietary glycemic load (GL), overall glycemic index (GI), and intake of total carbohydrates and mono- and disaccharides. DESIGN: The Netherlands Cohort Study consisted of 120,852 men and women who completed a baseline questionnaire in 1986. After 13.3 y of follow-up, 408 pancreatic cancer cases were detected, 66% of which were microscopically confirmed. A validated 150-item food-frequency questionnaire, completed at baseline, was used to calculate carbohydrate and mono- and disaccharide intakes and the GL and GI of the diet. RESULTS: Dietary GL, GI, or intake of carbohydrates and mono- and disaccharides were not associated with pancreatic cancer risk in this cohort. Also, the associations were not modified by sex. Our results did not change after the analysis was restricted to microscopically confirmed pancreatic cancer cases or after individuals who reported a history of diabetes at baseline were excluded from the analyses. CONCLUSIONS: Overall, our findings do not support the hypothesis that GL, GI, or intake of carbohydrates and mono- and disaccharides are positively associated with pancreatic cancer risk. This is in agreement with previous prospective studies that investigated the relation between GL and GI and pancreatic cancer risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18400721/Glycemic_load_glycemic_index_and_pancreatic_cancer_risk_in_the_Netherlands_Cohort_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/87.4.970 DB - PRIME DP - Unbound Medicine ER -