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Consumption of cured meats and prospective risk of chronic obstructive pulmonary disease in women.
Am J Clin Nutr. 2008 Apr; 87(4):1002-8.AJ

Abstract

BACKGROUND

Most cured meats contain nitrites. Nitrites generate oxidative-nitrative stress and were shown in animal models to cause emphysema. Prospective epidemiologic data on cured meats and chronic obstructive pulmonary disease (COPD), however, are sparse.

OBJECTIVE

We examined the relation between cured meat consumption and the prospective risk of newly diagnosed COPD in women.

DESIGN

This was a prospective cohort study of 71 531 women from the Nurses' Health Study who completed a validated dietary questionnaire at baseline in 1984 and had no baseline COPD or a report of asthma. Participants were aged 38-63 y in 1984 and were followed for 16 y.

RESULTS

A total of 750 new cases of COPD were documented during the follow-up. Cured meat consumption was positively associated with COPD risk after adjustment for age, smoking, and multiple other potential confounders. The adjusted relative risks of COPD across categories of cured meat consumption (never or almost never, 1-3 servings/mo, 1 serving/wk, 2-3 servings/wk, and > or = 4 servings/wk) were 1.0, 1.14 (95% CI: 0.78, 1.66), 1.15 (95% CI: 0.79, 1.69), 1.40 (95% CI: 0.96, 2.05), and 1.51 (95% CI: 1.00, 2.27), respectively, (P for trend = 0.005). This positive association was present among both past (P for trend = 0.02) and current (P for trend = 0.03) smokers. No association was observed among never smokers, probably because of the small number of COPD cases in these women.

CONCLUSION

Frequent cured meat consumption was associated with an increased risk of newly diagnosed COPD among women who smoke.

Links

Publisher Full Text
ncbi.nlm.nih.gov
academic.oup.com
PMC Free PDF

Authors+Show Affiliations

Jiang R
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Camargo CA
No affiliation info available
Varraso R
No affiliation info available
Paik DC
No affiliation info available
Willett WC
No affiliation info available
Barr RG
No affiliation info available

MeSH

AdultAgedCohort StudiesDietFemaleFollow-Up StudiesFood PreservationHumansMeat ProductsMiddle AgedNitritesProspective StudiesPulmonary Disease, Chronic ObstructiveRisk FactorsSmokingSurveys and QuestionnairesUnited States

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18400725

Clinical Trial Links

Endothelial Dysfunction, Biomarkers, and Lung Function -Ancillary to MESA

Citation

Jiang, Rui, et al. "Consumption of Cured Meats and Prospective Risk of Chronic Obstructive Pulmonary Disease in Women." The American Journal of Clinical Nutrition, vol. 87, no. 4, 2008, pp. 1002-8.
Jiang R, Camargo CA, Varraso R, et al. Consumption of cured meats and prospective risk of chronic obstructive pulmonary disease in women. Am J Clin Nutr. 2008;87(4):1002-8.
Jiang, R., Camargo, C. A., Varraso, R., Paik, D. C., Willett, W. C., & Barr, R. G. (2008). Consumption of cured meats and prospective risk of chronic obstructive pulmonary disease in women. The American Journal of Clinical Nutrition, 87(4), 1002-8.
Jiang R, et al. Consumption of Cured Meats and Prospective Risk of Chronic Obstructive Pulmonary Disease in Women. Am J Clin Nutr. 2008;87(4):1002-8. PubMed PMID: 18400725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of cured meats and prospective risk of chronic obstructive pulmonary disease in women. AU - Jiang,Rui, AU - Camargo,Carlos A,Jr AU - Varraso,Raphaelle, AU - Paik,David C, AU - Willett,Walter C, AU - Barr,R Graham, PY - 2008/4/11/pubmed PY - 2008/4/29/medline PY - 2008/4/11/entrez SP - 1002 EP - 8 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 87 IS - 4 N2 - BACKGROUND: Most cured meats contain nitrites. Nitrites generate oxidative-nitrative stress and were shown in animal models to cause emphysema. Prospective epidemiologic data on cured meats and chronic obstructive pulmonary disease (COPD), however, are sparse. OBJECTIVE: We examined the relation between cured meat consumption and the prospective risk of newly diagnosed COPD in women. DESIGN: This was a prospective cohort study of 71 531 women from the Nurses' Health Study who completed a validated dietary questionnaire at baseline in 1984 and had no baseline COPD or a report of asthma. Participants were aged 38-63 y in 1984 and were followed for 16 y. RESULTS: A total of 750 new cases of COPD were documented during the follow-up. Cured meat consumption was positively associated with COPD risk after adjustment for age, smoking, and multiple other potential confounders. The adjusted relative risks of COPD across categories of cured meat consumption (never or almost never, 1-3 servings/mo, 1 serving/wk, 2-3 servings/wk, and > or = 4 servings/wk) were 1.0, 1.14 (95% CI: 0.78, 1.66), 1.15 (95% CI: 0.79, 1.69), 1.40 (95% CI: 0.96, 2.05), and 1.51 (95% CI: 1.00, 2.27), respectively, (P for trend = 0.005). This positive association was present among both past (P for trend = 0.02) and current (P for trend = 0.03) smokers. No association was observed among never smokers, probably because of the small number of COPD cases in these women. CONCLUSION: Frequent cured meat consumption was associated with an increased risk of newly diagnosed COPD among women who smoke. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18400725/Consumption_of_cured_meats_and_prospective_risk_of_chronic_obstructive_pulmonary_disease_in_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/87.4.1002 DB - PRIME DP - Unbound Medicine ER -