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Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women's Health Initiative Observational Study.

Abstract

BACKGROUND

Few studies have evaluated carotenoids and vitamins C and E in association with the risk of breast cancers defined by estrogen receptor (ER) and progesterone receptor (PR) status.

OBJECTIVE

We examined the associations between dietary and supplemental intakes of these nutrients and risk of breast cancers jointly defined by both ER and PR status among postmenopausal women.

DESIGN

Our investigation was conducted in the Women's Health Initiative Observational Study. After following 84 805 women for an average of 7.6 y, 2879 incident invasive breast cancer cases had been ascertained, of whom 2509 had receptor data. We used Cox proportional hazards models to assess the associations of interest.

RESULTS

Dietary alpha-carotene (highest versus lowest quintile: RR = 0.83; 95% CL = 0.70, 0.99; P for trend = 0.019), beta-carotene (highest versus lowest quintile: RR = 0.78; 95% CL = 0.66, 0.94; P for trend = 0.021), and lycopene (highest versus lowest quintile: RR = 0.85; 95% CL = 0.73, 1.00; P for trend = 0.064) were inversely associated with risk of ER+PR+breast cancer, but not with other breast cancer groups jointly defined by ER and PR status. Total or supplemental beta-carotene and dietary intakes of lutein+zeaxanthin and beta-cryptoxanthin were not associated with breast cancers defined by ER and PR status. Vitamin E (regardless of source) and dietary vitamin C were not associated with breast cancer. However, total and supplemental vitamin C intake had weak positive associations with breast cancer overall.

CONCLUSION

Dietary intake of certain carotenoids might be differentially associated with risk of invasive breast cancers jointly defined by ER and PR status among postmenopausal women.

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    ,

    Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, CA 90012, USA. ycui@ph.lacounty.gov

    , , ,

    Source

    MeSH

    Aged
    Antioxidants
    Ascorbic Acid
    Breast Neoplasms
    Carotenoids
    Cohort Studies
    Diet
    Diet Surveys
    Dietary Supplements
    Female
    Follow-Up Studies
    Humans
    Middle Aged
    Postmenopause
    Proportional Hazards Models
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    United States
    Vitamin E

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    18400726

    Citation

    Cui, Yan, et al. "Selected Antioxidants and Risk of Hormone Receptor-defined Invasive Breast Cancers Among Postmenopausal Women in the Women's Health Initiative Observational Study." The American Journal of Clinical Nutrition, vol. 87, no. 4, 2008, pp. 1009-18.
    Cui Y, Shikany JM, Liu S, et al. Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women's Health Initiative Observational Study. Am J Clin Nutr. 2008;87(4):1009-18.
    Cui, Y., Shikany, J. M., Liu, S., Shagufta, Y., & Rohan, T. E. (2008). Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women's Health Initiative Observational Study. The American Journal of Clinical Nutrition, 87(4), pp. 1009-18.
    Cui Y, et al. Selected Antioxidants and Risk of Hormone Receptor-defined Invasive Breast Cancers Among Postmenopausal Women in the Women's Health Initiative Observational Study. Am J Clin Nutr. 2008;87(4):1009-18. PubMed PMID: 18400726.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women's Health Initiative Observational Study. AU - Cui,Yan, AU - Shikany,James M, AU - Liu,Simin, AU - Shagufta,Yasmeen, AU - Rohan,Thomas E, PY - 2008/4/11/pubmed PY - 2008/4/29/medline PY - 2008/4/11/entrez SP - 1009 EP - 18 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 87 IS - 4 N2 - BACKGROUND: Few studies have evaluated carotenoids and vitamins C and E in association with the risk of breast cancers defined by estrogen receptor (ER) and progesterone receptor (PR) status. OBJECTIVE: We examined the associations between dietary and supplemental intakes of these nutrients and risk of breast cancers jointly defined by both ER and PR status among postmenopausal women. DESIGN: Our investigation was conducted in the Women's Health Initiative Observational Study. After following 84 805 women for an average of 7.6 y, 2879 incident invasive breast cancer cases had been ascertained, of whom 2509 had receptor data. We used Cox proportional hazards models to assess the associations of interest. RESULTS: Dietary alpha-carotene (highest versus lowest quintile: RR = 0.83; 95% CL = 0.70, 0.99; P for trend = 0.019), beta-carotene (highest versus lowest quintile: RR = 0.78; 95% CL = 0.66, 0.94; P for trend = 0.021), and lycopene (highest versus lowest quintile: RR = 0.85; 95% CL = 0.73, 1.00; P for trend = 0.064) were inversely associated with risk of ER+PR+breast cancer, but not with other breast cancer groups jointly defined by ER and PR status. Total or supplemental beta-carotene and dietary intakes of lutein+zeaxanthin and beta-cryptoxanthin were not associated with breast cancers defined by ER and PR status. Vitamin E (regardless of source) and dietary vitamin C were not associated with breast cancer. However, total and supplemental vitamin C intake had weak positive associations with breast cancer overall. CONCLUSION: Dietary intake of certain carotenoids might be differentially associated with risk of invasive breast cancers jointly defined by ER and PR status among postmenopausal women. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18400726/Selected_antioxidants_and_risk_of_hormone_receptor_defined_invasive_breast_cancers_among_postmenopausal_women_in_the_Women's_Health_Initiative_Observational_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/87.4.1009 DB - PRIME DP - Unbound Medicine ER -