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Predictors of change in estimated GFR: a population-based 7-year follow-up from the Tromso study.
Nephrol Dial Transplant. 2008 Sep; 23(9):2818-26.ND

Abstract

BACKGROUND

Chronic kidney disease is associated with increased cardiovascular mortality, and even mild impairment of renal function is a cardiovascular risk factor. Several studies have investigated the risk factors for the development of end-stage renal disease, but little is known about predictors of change in renal function in the general population.

METHODS

The present study included 2249 men and 2192 women without signs of kidney disease at baseline who were followed for 7 years from 1994 to 1995 in the Tromsø Study. Estimated glomerular filtration rate (eGFR) was calculated from the Modification of Diet in Renal Disease study equation. Gender-specific multiple linear regression analyses were used to assess predictors of change in eGFR (DeltaGFR).

RESULTS

Change in eGFR, measured in ml/min/1.73 m(2)/year, was associated with systolic blood pressure (SBP) [beta-value for a 10-mmHg increase in SBP, men = -0.14, 95% confidence interval (CI) = -0.18 to -0.09; women = -0.07, 95% CI = -0.11 to -0.03] and fibrinogen [beta-value for 1 SD increase in fibrinogen, men (1 SD: 0.85 g/L) = -0.12, 95% CI -0.20 to -0.03; women (1 SD: 0.80) = -0.11, 95% CI -0.20 to -0.02]. High alcohol consumption in men and high physical activity in women predicted an increase in eGFR. Higher albumin/creatinine ratio was associated with a decline in eGFR in men only.

CONCLUSIONS

Some risk factors for change in GFR seem to be gender specific but both high SBP and high levels of fibrinogen contribute to a more rapid decline in GFR for both men and women.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Kronborg J
Department of Internal Medicine, Innlandet Hospital Trust, Olav Aukrustsvej 6 N-2618, Lillehammer, Norway. kronborg@broadpark.no
Solbu M
No affiliation info available
Njølstad I
No affiliation info available
Toft I
No affiliation info available
Eriksen BO
No affiliation info available
Jenssen T
No affiliation info available

MeSH

AgedAlcohol DrinkingBlood PressureCardiovascular DiseasesCreatinineFemaleFibrinogenFollow-Up StudiesGlomerular Filtration RateHealth SurveysHumansLinear ModelsMaleMiddle AgedNorwayRenal Insufficiency, ChronicRisk FactorsSex FactorsSmoking

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18400822

Citation

Kronborg, Jens, et al. "Predictors of Change in Estimated GFR: a Population-based 7-year Follow-up From the Tromso Study." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 23, no. 9, 2008, pp. 2818-26.
Kronborg J, Solbu M, Njølstad I, et al. Predictors of change in estimated GFR: a population-based 7-year follow-up from the Tromso study. Nephrol Dial Transplant. 2008;23(9):2818-26.
Kronborg, J., Solbu, M., Njølstad, I., Toft, I., Eriksen, B. O., & Jenssen, T. (2008). Predictors of change in estimated GFR: a population-based 7-year follow-up from the Tromso study. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 23(9), 2818-26. https://doi.org/10.1093/ndt/gfn148
Kronborg J, et al. Predictors of Change in Estimated GFR: a Population-based 7-year Follow-up From the Tromso Study. Nephrol Dial Transplant. 2008;23(9):2818-26. PubMed PMID: 18400822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of change in estimated GFR: a population-based 7-year follow-up from the Tromso study. AU - Kronborg,Jens, AU - Solbu,Marit, AU - Njølstad,Inger, AU - Toft,Ingrid, AU - Eriksen,Bjørn O, AU - Jenssen,Trond, Y1 - 2008/04/09/ PY - 2008/4/11/pubmed PY - 2009/2/12/medline PY - 2008/4/11/entrez SP - 2818 EP - 26 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol Dial Transplant VL - 23 IS - 9 N2 - BACKGROUND: Chronic kidney disease is associated with increased cardiovascular mortality, and even mild impairment of renal function is a cardiovascular risk factor. Several studies have investigated the risk factors for the development of end-stage renal disease, but little is known about predictors of change in renal function in the general population. METHODS: The present study included 2249 men and 2192 women without signs of kidney disease at baseline who were followed for 7 years from 1994 to 1995 in the Tromsø Study. Estimated glomerular filtration rate (eGFR) was calculated from the Modification of Diet in Renal Disease study equation. Gender-specific multiple linear regression analyses were used to assess predictors of change in eGFR (DeltaGFR). RESULTS: Change in eGFR, measured in ml/min/1.73 m(2)/year, was associated with systolic blood pressure (SBP) [beta-value for a 10-mmHg increase in SBP, men = -0.14, 95% confidence interval (CI) = -0.18 to -0.09; women = -0.07, 95% CI = -0.11 to -0.03] and fibrinogen [beta-value for 1 SD increase in fibrinogen, men (1 SD: 0.85 g/L) = -0.12, 95% CI -0.20 to -0.03; women (1 SD: 0.80) = -0.11, 95% CI -0.20 to -0.02]. High alcohol consumption in men and high physical activity in women predicted an increase in eGFR. Higher albumin/creatinine ratio was associated with a decline in eGFR in men only. CONCLUSIONS: Some risk factors for change in GFR seem to be gender specific but both high SBP and high levels of fibrinogen contribute to a more rapid decline in GFR for both men and women. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/18400822/Predictors_of_change_in_estimated_GFR:_a_population_based_7_year_follow_up_from_the_Tromso_study_ DB - PRIME DP - Unbound Medicine ER -