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Distribution of APOE genotypes in a memory clinic cohort.
Dement Geriatr Cogn Disord 2008; 25(5):433-8DG

Abstract

AIM

To describe the distribution of apolipoprotein E (APOE) genotypes in a cohort of memory clinic patients.

METHODS

We included 749 memory clinic patients. Diagnoses were made in a multidisciplinary consensus meeting and the APOE genotype was determined. The community-based cohort of the Longitudinal Aging Study Amsterdam was used as control population (n = 2,233).

RESULTS

In the memory clinic sample, there were 173 patients with subjective complaints, 125 patients with mild cognitive impairment (MCI), 251 patients with Alzheimer disease (AD), 107 patients with another type of dementia, and 93 patients with another neurologic or psychiatric diagnosis. The APOE allele distribution differed among groups. There was no difference in the prevalence of the epsilon2 allele, but there were differences in distribution of the epsilon3 and epsilon4 alleles. Compared with the control population (15%), the prevalence of APOE epsilon4 was increased among patients with subjective complaints (22%), MCI (36%), AD (42%) and other types of dementia (25%).

CONCLUSION

We observed an increased prevalence of APOE epsilon4 in patients with MCI and subjective complaints. This finding is of great clinical importance as nondemented patients positive for APOE epsilon4 could be identified as being at genetic risk of AD, and for that reason monitored more closely.

Authors+Show Affiliations

Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18401171

Citation

van der Flier, W M., et al. "Distribution of APOE Genotypes in a Memory Clinic Cohort." Dementia and Geriatric Cognitive Disorders, vol. 25, no. 5, 2008, pp. 433-8.
van der Flier WM, Pijnenburg YA, Schoonenboom SN, et al. Distribution of APOE genotypes in a memory clinic cohort. Dement Geriatr Cogn Disord. 2008;25(5):433-8.
van der Flier, W. M., Pijnenburg, Y. A., Schoonenboom, S. N., Dik, M. G., Blankenstein, M. A., & Scheltens, P. (2008). Distribution of APOE genotypes in a memory clinic cohort. Dementia and Geriatric Cognitive Disorders, 25(5), pp. 433-8. doi:10.1159/000124750.
van der Flier WM, et al. Distribution of APOE Genotypes in a Memory Clinic Cohort. Dement Geriatr Cogn Disord. 2008;25(5):433-8. PubMed PMID: 18401171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of APOE genotypes in a memory clinic cohort. AU - van der Flier,W M, AU - Pijnenburg,Y A L, AU - Schoonenboom,S N M, AU - Dik,M G, AU - Blankenstein,M A, AU - Scheltens,P, Y1 - 2008/04/10/ PY - 2008/01/23/accepted PY - 2008/4/11/pubmed PY - 2008/6/18/medline PY - 2008/4/11/entrez SP - 433 EP - 8 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 25 IS - 5 N2 - AIM: To describe the distribution of apolipoprotein E (APOE) genotypes in a cohort of memory clinic patients. METHODS: We included 749 memory clinic patients. Diagnoses were made in a multidisciplinary consensus meeting and the APOE genotype was determined. The community-based cohort of the Longitudinal Aging Study Amsterdam was used as control population (n = 2,233). RESULTS: In the memory clinic sample, there were 173 patients with subjective complaints, 125 patients with mild cognitive impairment (MCI), 251 patients with Alzheimer disease (AD), 107 patients with another type of dementia, and 93 patients with another neurologic or psychiatric diagnosis. The APOE allele distribution differed among groups. There was no difference in the prevalence of the epsilon2 allele, but there were differences in distribution of the epsilon3 and epsilon4 alleles. Compared with the control population (15%), the prevalence of APOE epsilon4 was increased among patients with subjective complaints (22%), MCI (36%), AD (42%) and other types of dementia (25%). CONCLUSION: We observed an increased prevalence of APOE epsilon4 in patients with MCI and subjective complaints. This finding is of great clinical importance as nondemented patients positive for APOE epsilon4 could be identified as being at genetic risk of AD, and for that reason monitored more closely. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/18401171/Distribution_of_APOE_genotypes_in_a_memory_clinic_cohort_ L2 - https://www.karger.com?DOI=10.1159/000124750 DB - PRIME DP - Unbound Medicine ER -