Tags

Type your tag names separated by a space and hit enter

EVI5 is a risk gene for multiple sclerosis.
Genes Immun 2008; 9(4):334-7GI

Abstract

HLA-DRB1 is the major locus associated with risk for multiple sclerosis (MS). A recent genome-wide study showed three additional single-nucleotide polymorphisms (SNPs), within the IL2RA and IL7RA genes respectively, also to be associated with MS. Consistent association but lower significance was found for 13 other SNPs. In this study, we aimed to verify association of these SNPs with MS in 46 MS patients and 194 controls from a Dutch genetically isolated population. Apart from the human leukocyte antigen locus, the EVI5 gene on chromosome 1 was confirmed as a novel risk gene, with odds ratios (ORs) even higher than those from the MS Consortium (ORs 2.01 and 1.9; P=0.01). The risk effect of EVI5 was further validated for the general MS population in an independent set of 1318 MS patients from the Canadian Collaborative Project on the Genetic Susceptibility to MS. On the basis of the transmission disequilibrium testing, a weak but significant risk effect was observed (OR 1.15; P=0.03 and OR 1.15; P=0.04). This study confirms EVI5 as another risk locus for MS; however, much of the genetic basis of MS remains unidentified.

Authors+Show Affiliations

Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18401352

Citation

Hoppenbrouwers, I A., et al. "EVI5 Is a Risk Gene for Multiple Sclerosis." Genes and Immunity, vol. 9, no. 4, 2008, pp. 334-7.
Hoppenbrouwers IA, Aulchenko YS, Ebers GC, et al. EVI5 is a risk gene for multiple sclerosis. Genes Immun. 2008;9(4):334-7.
Hoppenbrouwers, I. A., Aulchenko, Y. S., Ebers, G. C., Ramagopalan, S. V., Oostra, B. A., van Duijn, C. M., & Hintzen, R. Q. (2008). EVI5 is a risk gene for multiple sclerosis. Genes and Immunity, 9(4), pp. 334-7. doi:10.1038/gene.2008.22.
Hoppenbrouwers IA, et al. EVI5 Is a Risk Gene for Multiple Sclerosis. Genes Immun. 2008;9(4):334-7. PubMed PMID: 18401352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - EVI5 is a risk gene for multiple sclerosis. AU - Hoppenbrouwers,I A, AU - Aulchenko,Y S, AU - Ebers,G C, AU - Ramagopalan,S V, AU - Oostra,B A, AU - van Duijn,C M, AU - Hintzen,R Q, Y1 - 2008/04/10/ PY - 2008/4/11/pubmed PY - 2008/8/30/medline PY - 2008/4/11/entrez SP - 334 EP - 7 JF - Genes and immunity JO - Genes Immun. VL - 9 IS - 4 N2 - HLA-DRB1 is the major locus associated with risk for multiple sclerosis (MS). A recent genome-wide study showed three additional single-nucleotide polymorphisms (SNPs), within the IL2RA and IL7RA genes respectively, also to be associated with MS. Consistent association but lower significance was found for 13 other SNPs. In this study, we aimed to verify association of these SNPs with MS in 46 MS patients and 194 controls from a Dutch genetically isolated population. Apart from the human leukocyte antigen locus, the EVI5 gene on chromosome 1 was confirmed as a novel risk gene, with odds ratios (ORs) even higher than those from the MS Consortium (ORs 2.01 and 1.9; P=0.01). The risk effect of EVI5 was further validated for the general MS population in an independent set of 1318 MS patients from the Canadian Collaborative Project on the Genetic Susceptibility to MS. On the basis of the transmission disequilibrium testing, a weak but significant risk effect was observed (OR 1.15; P=0.03 and OR 1.15; P=0.04). This study confirms EVI5 as another risk locus for MS; however, much of the genetic basis of MS remains unidentified. SN - 1476-5470 UR - https://www.unboundmedicine.com/medline/citation/18401352/EVI5_is_a_risk_gene_for_multiple_sclerosis_ L2 - http://dx.doi.org/10.1038/gene.2008.22 DB - PRIME DP - Unbound Medicine ER -