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Effects of lifestyle modification on adipocytokine levels in obese patients.
Eur Rev Med Pharmacol Sci. 2008 Jan-Feb; 12(1):33-9.ER

Abstract

OBJECTIVE

Adipose tissue is considered an active secretory organ of adipocytokines. The principal aim of our study was to examine the changes in adipocytokines levels after weigth reduction in obese patients.

MATERIALS AND METHODS

A population of 126 obese (body mass index > 30) non-diabetic outpatients was analyzed in a prospective way. Before and after three months of a lifestyle modification program, an indirect calorimetry, a tetrapolar electrical bioimpedance, blood pressure, a serial assessment of nutritional intake with 3 days written food records and a series of biochemical analyses were performed. The lifestyle modification program consisted of a daily hypocaloric diet (1520 kcal: 52% of carbohydrates, 25% of lipids and 23% of proteins). The exercise program consisted of an aerobic exercise for at least 3 times per week (60 minutes each).

RESULTS

The mean age was 45.6 +/- 16.9 years and the mean BMI 34.5 +/- 5.2, with 33 males (26.2%) and 93 females (73.8%). A total of 88 patients completed the follow up during 3 months, with a percentage of weight loss of 3.1%. Seventy two patients lost weight after treatment (responders) with an average age of 45.4 +/- 16.8 years and a percentage of weight loss of 4.2%. Sixteen patients did not respond (no-responders), with an increase in weight (88.9 +/- 10.5 vs 88.7 +/- 10.9 kg: p < 0.05) and BMI (34.7 +/- 5.4 vs 35.5 +/- 5.5 kg: p < 0.05). The average age (45.9 +/- 15.9 years) of this group was similar than that of responders. In responders (weight loss), BMI, weight, fat mass, glucose, total cholesterol, LDL cholesterol and systolic blood pressure decreased and VO2 increased. After treatment, no statistical differences were detected in energy intake: carbohydrate, fat, and protein. Exercise improved after treatment in responder group. Only serum leptin levels had a significant decrease in responder group (12%). After treatment, no responder group has similar values of all adipokines, including leptin (81.3 +/- 70.6 vs. 76.1 +/- 43 ng/ml).

CONCLUSION

Three months of lifestyle modification significantly improved anthropometric and cardiovascular risk factors, regardless of their minimal decrease in energy intake and the weight loss. Additional studies will be need to clarify the contribution of lifestyle modification in changes of serum adipocytokine levels.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega RD056/0013, University of Valladolid, Valladolid, Spain. dadluis@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18401970

Citation

De Luis, D A., et al. "Effects of Lifestyle Modification On Adipocytokine Levels in Obese Patients." European Review for Medical and Pharmacological Sciences, vol. 12, no. 1, 2008, pp. 33-9.
De Luis DA, Aller R, Izaola O, et al. Effects of lifestyle modification on adipocytokine levels in obese patients. Eur Rev Med Pharmacol Sci. 2008;12(1):33-9.
De Luis, D. A., Aller, R., Izaola, O., Gonzalez Sagrado, M., Conde, R., & Perez Castrillon, J. L. (2008). Effects of lifestyle modification on adipocytokine levels in obese patients. European Review for Medical and Pharmacological Sciences, 12(1), 33-9.
De Luis DA, et al. Effects of Lifestyle Modification On Adipocytokine Levels in Obese Patients. Eur Rev Med Pharmacol Sci. 2008 Jan-Feb;12(1):33-9. PubMed PMID: 18401970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of lifestyle modification on adipocytokine levels in obese patients. AU - De Luis,D A, AU - Aller,R, AU - Izaola,O, AU - Gonzalez Sagrado,M, AU - Conde,R, AU - Perez Castrillon,J L, PY - 2008/4/12/pubmed PY - 2008/5/9/medline PY - 2008/4/12/entrez SP - 33 EP - 9 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 12 IS - 1 N2 - OBJECTIVE: Adipose tissue is considered an active secretory organ of adipocytokines. The principal aim of our study was to examine the changes in adipocytokines levels after weigth reduction in obese patients. MATERIALS AND METHODS: A population of 126 obese (body mass index > 30) non-diabetic outpatients was analyzed in a prospective way. Before and after three months of a lifestyle modification program, an indirect calorimetry, a tetrapolar electrical bioimpedance, blood pressure, a serial assessment of nutritional intake with 3 days written food records and a series of biochemical analyses were performed. The lifestyle modification program consisted of a daily hypocaloric diet (1520 kcal: 52% of carbohydrates, 25% of lipids and 23% of proteins). The exercise program consisted of an aerobic exercise for at least 3 times per week (60 minutes each). RESULTS: The mean age was 45.6 +/- 16.9 years and the mean BMI 34.5 +/- 5.2, with 33 males (26.2%) and 93 females (73.8%). A total of 88 patients completed the follow up during 3 months, with a percentage of weight loss of 3.1%. Seventy two patients lost weight after treatment (responders) with an average age of 45.4 +/- 16.8 years and a percentage of weight loss of 4.2%. Sixteen patients did not respond (no-responders), with an increase in weight (88.9 +/- 10.5 vs 88.7 +/- 10.9 kg: p < 0.05) and BMI (34.7 +/- 5.4 vs 35.5 +/- 5.5 kg: p < 0.05). The average age (45.9 +/- 15.9 years) of this group was similar than that of responders. In responders (weight loss), BMI, weight, fat mass, glucose, total cholesterol, LDL cholesterol and systolic blood pressure decreased and VO2 increased. After treatment, no statistical differences were detected in energy intake: carbohydrate, fat, and protein. Exercise improved after treatment in responder group. Only serum leptin levels had a significant decrease in responder group (12%). After treatment, no responder group has similar values of all adipokines, including leptin (81.3 +/- 70.6 vs. 76.1 +/- 43 ng/ml). CONCLUSION: Three months of lifestyle modification significantly improved anthropometric and cardiovascular risk factors, regardless of their minimal decrease in energy intake and the weight loss. Additional studies will be need to clarify the contribution of lifestyle modification in changes of serum adipocytokine levels. SN - 1128-3602 UR - https://www.unboundmedicine.com/medline/citation/18401970/Effects_of_lifestyle_modification_on_adipocytokine_levels_in_obese_patients_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -