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Epidemiological characteristics of tsutsugamushi disease in Oita Prefecture, Japan: yearly and monthly occurrences of its infections and serotypes of its causative agent, Orientia tsutsugamushi, during 1984--2005.
Microbiol Immunol. 2008 Mar; 52(3):135-43.MI

Abstract

Using indirect immunofluorescence assay, we examined the sera of 561 patients from November 1984 to February 2005 to determine the incidence of tsutsugamushi disease (scrub typhus) in Oita Prefecture, Japan. The results obtained were positive in 384 individuals (68.4%). Municipalities where patients were presumed to have been infected with Orientia tsutsugamushi were Taketa City (41.7%), Oyama Town (13.5%), and Ogi Town (8.3%). Infections occurred most often in October, November, and December. A small number of cases occurred from January to May. The serotypes Kuroki (47.5%), Kawasaki (42.5%), and Karp (10.0%) were detected by genetic analysis of O. tsutsugamushi DNA extracted from the blood of 120 patients. The gene sequences of the Kuroki type were highly homologous to that of the Nishino strain. The gene sequences of the Kawasaki type were identical to that of the Kawasaki strain. The gene sequence of the Karp type was highly homologous to that of the JP-2 type. To determine the distribution of vector mites, 558 wild rodents were captured and 72010 mites attached to these rodents were collected from 1982 to 1998. Six genera and 16 species of trombiculid mites were collected. Leptotrombidium pallidum and L. scutellare, which are known to be mite vectors for tsutsugamushi disease, accounted for 20.5% and 5.9%, respectively, of all trombiculid mites collected. The geographical distribution of cases roughly coincided with the distribution of L. scutellare. In Oita Prefecture, L. scutellare is presumed to primarily transmit tsutsugamushi disease. In addition, our results also suggest that L. pallidum transmits the Karp type of the causative rickettsia in some municipalities.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ogawa M
Oita Prefectural Institute of Health and Environment, Oita, Japan. ogawa-masao@pref.oita.lg.jp
Ono T
No affiliation info available

MeSH

AnimalsAntibodies, BacterialCluster AnalysisDNA, BacterialDisease VectorsFluorescent Antibody Technique, IndirectGeographyHumansIncidenceJapanOrientia tsutsugamushiPhylogenyRodentiaScrub TyphusSeasonsSequence HomologySeroepidemiologic StudiesSerotypingTrombiculidae

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18402595

Citation

Ogawa, Masao, and Testuro Ono. "Epidemiological Characteristics of Tsutsugamushi Disease in Oita Prefecture, Japan: Yearly and Monthly Occurrences of Its Infections and Serotypes of Its Causative Agent, Orientia Tsutsugamushi, During 1984--2005." Microbiology and Immunology, vol. 52, no. 3, 2008, pp. 135-43.
Ogawa M, Ono T. Epidemiological characteristics of tsutsugamushi disease in Oita Prefecture, Japan: yearly and monthly occurrences of its infections and serotypes of its causative agent, Orientia tsutsugamushi, during 1984--2005. Microbiol Immunol. 2008;52(3):135-43.
Ogawa, M., & Ono, T. (2008). Epidemiological characteristics of tsutsugamushi disease in Oita Prefecture, Japan: yearly and monthly occurrences of its infections and serotypes of its causative agent, Orientia tsutsugamushi, during 1984--2005. Microbiology and Immunology, 52(3), 135-43. https://doi.org/10.1111/j.1348-0421.2008.00024.x
Ogawa M, Ono T. Epidemiological Characteristics of Tsutsugamushi Disease in Oita Prefecture, Japan: Yearly and Monthly Occurrences of Its Infections and Serotypes of Its Causative Agent, Orientia Tsutsugamushi, During 1984--2005. Microbiol Immunol. 2008;52(3):135-43. PubMed PMID: 18402595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiological characteristics of tsutsugamushi disease in Oita Prefecture, Japan: yearly and monthly occurrences of its infections and serotypes of its causative agent, Orientia tsutsugamushi, during 1984--2005. AU - Ogawa,Masao, AU - Ono,Testuro, PY - 2008/4/12/pubmed PY - 2008/9/13/medline PY - 2008/4/12/entrez SP - 135 EP - 43 JF - Microbiology and immunology JO - Microbiol Immunol VL - 52 IS - 3 N2 - Using indirect immunofluorescence assay, we examined the sera of 561 patients from November 1984 to February 2005 to determine the incidence of tsutsugamushi disease (scrub typhus) in Oita Prefecture, Japan. The results obtained were positive in 384 individuals (68.4%). Municipalities where patients were presumed to have been infected with Orientia tsutsugamushi were Taketa City (41.7%), Oyama Town (13.5%), and Ogi Town (8.3%). Infections occurred most often in October, November, and December. A small number of cases occurred from January to May. The serotypes Kuroki (47.5%), Kawasaki (42.5%), and Karp (10.0%) were detected by genetic analysis of O. tsutsugamushi DNA extracted from the blood of 120 patients. The gene sequences of the Kuroki type were highly homologous to that of the Nishino strain. The gene sequences of the Kawasaki type were identical to that of the Kawasaki strain. The gene sequence of the Karp type was highly homologous to that of the JP-2 type. To determine the distribution of vector mites, 558 wild rodents were captured and 72010 mites attached to these rodents were collected from 1982 to 1998. Six genera and 16 species of trombiculid mites were collected. Leptotrombidium pallidum and L. scutellare, which are known to be mite vectors for tsutsugamushi disease, accounted for 20.5% and 5.9%, respectively, of all trombiculid mites collected. The geographical distribution of cases roughly coincided with the distribution of L. scutellare. In Oita Prefecture, L. scutellare is presumed to primarily transmit tsutsugamushi disease. In addition, our results also suggest that L. pallidum transmits the Karp type of the causative rickettsia in some municipalities. SN - 0385-5600 UR - https://www.unboundmedicine.com/medline/citation/18402595/Epidemiological_characteristics_of_tsutsugamushi_disease_in_Oita_Prefecture_Japan:_yearly_and_monthly_occurrences_of_its_infections_and_serotypes_of_its_causative_agent_Orientia_tsutsugamushi_during_1984__2005_ DB - PRIME DP - Unbound Medicine ER -