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Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania.

Abstract

Studies have consistently reported the participation of free radicals in Bipolar Disorder. Administration of d-amphetamine (d-AMPH) is a relevant animal model of mania and it increases oxidative stress in rat brain. Evidences indicate that the antioxidants N-acetylcysteine (NAC) and Deferoxamine (DFX) exert protective effects in the brain. The present study was designed to evaluate the effects of NAC, DFX or their combination on AMPH-induced hyperactivity. The protein oxidation levels were analyzed in prefrontal cortex and hippocampus. In the first animal model (reversal treatment), adult male Wistar rats received saline or d-AMPH for 14 days, and from the 8th to the 14th day, they were treated with saline, NAC, DFX, or NAC plus DFX. In the second animal model (prevention treatment), rats were pretreated with saline or antioxidant regime, and from the 8th to the 14th day, they also received saline or d-AMPH. In the prefrontal cortex, the protein carbonyls were not affected by the treatment with antioxidants alone but it was increased by treatment with NAC plus DFX. At the same model, NAC plus DFX reversed the protein damage in the hippocampus, but NAC alone increased this damage. In the prevention treatment, it was observed that the protein damage in the prefrontal cortex was prevented by DFX or NAC plus DFX. In the hippocampus, the pretreatment with all antioxidant regime prevented protein damage induced by d-AMPH. At both treatments (reversal or prevention) the antioxidants did not present any effect against d-AMPH-induced hyperactivity. In conclusion, NAC or DFX and the combination of NAC plus DFX reverse and protect against d-AMPH-induced oxidative protein damage. Using these protocols we could not observe affects on locomotion, however this effect varies depending on the brain region and the treatment regime.

Authors+Show Affiliations

Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18403082

Citation

Valvassori, Samira S., et al. "Effect of N-acetylcysteine And/or Deferoxamine On Oxidative Stress and Hyperactivity in an Animal Model of Mania." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 32, no. 4, 2008, pp. 1064-8.
Valvassori SS, Petronilho FC, Réus GZ, et al. Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(4):1064-8.
Valvassori, S. S., Petronilho, F. C., Réus, G. Z., Steckert, A. V., Oliveira, V. B., Boeck, C. R., ... Quevedo, J. (2008). Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania. Progress in Neuro-psychopharmacology & Biological Psychiatry, 32(4), pp. 1064-8. doi:10.1016/j.pnpbp.2008.02.012.
Valvassori SS, et al. Effect of N-acetylcysteine And/or Deferoxamine On Oxidative Stress and Hyperactivity in an Animal Model of Mania. Prog Neuropsychopharmacol Biol Psychiatry. 2008 May 15;32(4):1064-8. PubMed PMID: 18403082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania. AU - Valvassori,Samira S, AU - Petronilho,Fabrícia C, AU - Réus,Gislaine Z, AU - Steckert,Amanda V, AU - Oliveira,Virgínia B M, AU - Boeck,Carina R, AU - Kapczinski,Flávio, AU - Dal-Pizzol,Felipe, AU - Quevedo,João, Y1 - 2008/03/04/ PY - 2007/11/11/received PY - 2008/02/20/revised PY - 2008/02/26/accepted PY - 2008/4/12/pubmed PY - 2008/7/23/medline PY - 2008/4/12/entrez SP - 1064 EP - 8 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 32 IS - 4 N2 - Studies have consistently reported the participation of free radicals in Bipolar Disorder. Administration of d-amphetamine (d-AMPH) is a relevant animal model of mania and it increases oxidative stress in rat brain. Evidences indicate that the antioxidants N-acetylcysteine (NAC) and Deferoxamine (DFX) exert protective effects in the brain. The present study was designed to evaluate the effects of NAC, DFX or their combination on AMPH-induced hyperactivity. The protein oxidation levels were analyzed in prefrontal cortex and hippocampus. In the first animal model (reversal treatment), adult male Wistar rats received saline or d-AMPH for 14 days, and from the 8th to the 14th day, they were treated with saline, NAC, DFX, or NAC plus DFX. In the second animal model (prevention treatment), rats were pretreated with saline or antioxidant regime, and from the 8th to the 14th day, they also received saline or d-AMPH. In the prefrontal cortex, the protein carbonyls were not affected by the treatment with antioxidants alone but it was increased by treatment with NAC plus DFX. At the same model, NAC plus DFX reversed the protein damage in the hippocampus, but NAC alone increased this damage. In the prevention treatment, it was observed that the protein damage in the prefrontal cortex was prevented by DFX or NAC plus DFX. In the hippocampus, the pretreatment with all antioxidant regime prevented protein damage induced by d-AMPH. At both treatments (reversal or prevention) the antioxidants did not present any effect against d-AMPH-induced hyperactivity. In conclusion, NAC or DFX and the combination of NAC plus DFX reverse and protect against d-AMPH-induced oxidative protein damage. Using these protocols we could not observe affects on locomotion, however this effect varies depending on the brain region and the treatment regime. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/18403082/Effect_of_N_acetylcysteine_and/or_deferoxamine_on_oxidative_stress_and_hyperactivity_in_an_animal_model_of_mania_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(08)00073-0 DB - PRIME DP - Unbound Medicine ER -