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Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats.

Abstract

We investigated whether administration of MOD in rats during the lights-on period into wake-promoting areas, such as anterior hypothalamus (AH) or into the pedunculopontine tegmental nucleus (PPTg) would enhance waking. Results showed that microinjections of 1 microL of MOD (10, 20, or 30 microg) into both brain areas increased the total time of alertness and decreased sleep. Additionally, MOD-treated rats showed an enhancement in alpha power spectra but delta power spectra was diminished. Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg.

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  • Authors+Show Affiliations

    ,

    Laboratorio de Neurobiología, Facultad de Medicina, Universidad Autónoma de Campeche, Campeche, Mexico. emurillo@uacam.mx

    , , ,

    Source

    Neuroscience letters 436:2 2008 May 09 pg 283-7

    MeSH

    Analysis of Variance
    Animals
    Anterior Hypothalamic Nucleus
    Behavior, Animal
    Benzhydryl Compounds
    Central Nervous System Stimulants
    Dose-Response Relationship, Drug
    Electroencephalography
    Male
    Modafinil
    Oncogene Proteins v-fos
    Pedunculopontine Tegmental Nucleus
    Rats
    Rats, Wistar
    Sleep Stages
    Wakefulness

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18403119

    Citation

    Murillo-Rodríguez, Eric, et al. "Promoting of Wakefulness By Administrations of Modafinil Into Anterior Hypothalamus and Into the Pedunculopontine Tegmental Nucleus in Rats." Neuroscience Letters, vol. 436, no. 2, 2008, pp. 283-7.
    Murillo-Rodríguez E, Vázquez-Luis E, Millán-Aldaco D, et al. Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats. Neurosci Lett. 2008;436(2):283-7.
    Murillo-Rodríguez, E., Vázquez-Luis, E., Millán-Aldaco, D., Haro, R., & Drucker-Colín, R. (2008). Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats. Neuroscience Letters, 436(2), pp. 283-7. doi:10.1016/j.neulet.2008.03.048.
    Murillo-Rodríguez E, et al. Promoting of Wakefulness By Administrations of Modafinil Into Anterior Hypothalamus and Into the Pedunculopontine Tegmental Nucleus in Rats. Neurosci Lett. 2008 May 9;436(2):283-7. PubMed PMID: 18403119.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats. AU - Murillo-Rodríguez,Eric, AU - Vázquez-Luis,Edgar, AU - Millán-Aldaco,Diana, AU - Haro,Reyes, AU - Drucker-Colín,René, Y1 - 2008/03/22/ PY - 2007/11/15/received PY - 2008/03/03/revised PY - 2008/03/19/accepted PY - 2008/4/12/pubmed PY - 2008/8/14/medline PY - 2008/4/12/entrez SP - 283 EP - 7 JF - Neuroscience letters JO - Neurosci. Lett. VL - 436 IS - 2 N2 - We investigated whether administration of MOD in rats during the lights-on period into wake-promoting areas, such as anterior hypothalamus (AH) or into the pedunculopontine tegmental nucleus (PPTg) would enhance waking. Results showed that microinjections of 1 microL of MOD (10, 20, or 30 microg) into both brain areas increased the total time of alertness and decreased sleep. Additionally, MOD-treated rats showed an enhancement in alpha power spectra but delta power spectra was diminished. Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/18403119/Promoting_of_wakefulness_by_administrations_of_modafinil_into_anterior_hypothalamus_and_into_the_pedunculopontine_tegmental_nucleus_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(08)00375-3 DB - PRIME DP - Unbound Medicine ER -